Cardiac troponin I and the occurrence of cardiac arrhythmias in horses with experimentally induced endotoxaemia

Nostell, Katarina; Bröjer, Johan; Höglund, Katja; Edner, Anna; Häggström, Jens

doi:10.1016/j.tvjl.2011.05.013

Cited by 43 publications

(45 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The fact that both cTnI concentration and HR are prognosis indicators emphasizes on the importance of objective cardiovascular system assessment in DCS. Increased cTnI concentrations have been observed in human medicine with rhabdomyolysis, sepsis, hypotension/hypovolemia, renal failure, gastrointestinal bleeding, and stress‐induced cardiomyopathy and with induced endotoxemia in calves and horses . All those conditions might be present at different extent in cows affected by DCS in regards to the primary cause of recumbency (i.e.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Cardiac Troponin I and L‐Lactate in Blood of Dairy Cows Affected by Downer Cow Syndrome

Labonté¹,

Dubuc

Roy

et al. 2017

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundThe downer cow syndrome (DCS) is a challenging health issue in the dairy industry. No cow‐side test is available to provide an accurate prognosis for DCS cases in farm settings.Hypothesis/ObjectivesLocal or systemic hypoperfusion and myocardial lesions lead to an increase in blood concentration of biomarkers cardiac troponin I (cTnI) and L‐lactate. The objective was to determine the prognostic values of these biomarkers assessed cow‐sides in addition to clinical examinations in prognostication of a negative outcome (NO: death or euthanasia within 7 days).Animals218 client‐owned dairy cows affected by DCS.MethodsIn a prospective study, animals were monitored for 60 days after inclusion of each cow. Blood cTnI and L‐lactate concentrations were measured on the day of inclusion. The prognostic accuracy of both biomarkers and physical examination variables was estimated to predict NO. A mixed multivariable logistic regression model was used for data analysis.ResultsPrevalence of NO in this study was 63% on day 7. Troponin concentrations greater than 0.7 ng/mL had sensitivity and specificity of 54.1% (95% CI: 45.3–62.7%) and 78.4% (95% CI: 67.3–87.1%), respectively, for predicting NO. Blood L‐lactate was not associated with the outcome. The multivariable model revealed that heart rate >100 bpm (OR; 95% CI: 3.7; 1.3–10.2) and cTnI > 0.7 ng/mL (OR; 95% CI: 5.5; 2.1–14.6) were associated with the risk of NO.Conclusions and Clinical ImportanceHypertroponinemia and tachycardia were associated with reduced survival in DCS cases. The use of cow‐side blood cTnI concentrations and heart rate could help to rapidly identify cows in farm setting that have poor chances of recovery and would benefit from a more aggressive treatment or euthanasia.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Cardiac Troponin I and L‐Lactate in Blood of Dairy Cows Affected by Downer Cow Syndrome

Labonté¹,

Dubuc

Roy

et al. 2017

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…High serum concentrations of cTnI occur in horses with ventricular tachyarrhythmias, monensin toxicosis, atypical myopathy, atrial fibrillation, structural heart disease, and amyloidosis [3,6,7,8]. cTnI is also increase with non-cardiac diseases that induces secondary cardiac involvement, as example with babesiosis and endotoxaemia [9,10]. Release of cTnI during and after exercise also has been described in equine athletes after racing or race training, endurance rides or treadmill exercise [11,12,14,13].…”

Section: Introductionmentioning

confidence: 99%

Influence of Cavalcade of Different Distances on the Serum Concentrations of the Cardiac Biomarkers Troponin I (Ctni) and Creatine Kinase Myocardial Band (CK-MB) in Horses

Filippo¹

2017

SOJVS

View full text Add to dashboard Cite

Cardiac biomarkers are potentially useful to identify primary or secondary cardiac muscle damage in horses and higher values of cardiac troponin have also been seen after high intensity exercise. The objective of this study was to investigate the effect of cavalcade of different distances on the serum concentrations of cardiac troponin I (cTnI) and creatine kinase myocardial band (CK-MB) in Mangalarga Marchador horses. Fifteen clinically normal geldings (age 6.2 ± 1.2 years, weight 420 ± 58 kg) were distributed into three groups of five animals each. The groups were submitted to cavalcade along 4 km (G4), 8 km (G8), and 20 km (G20) at mean speeds of 15 km h , respectively. From each horse, blood samples were collected after and post-exercise. Serum cTnI and CK-MB concentrations were determined with a solid-phase chemoluminescence immunoassay. The assay has an analytical sensitivity of 0.02 ng mL-1. The concentration of blood lactate was analyzed using an i-STAT portable clinical analyzer. After exercise, increases (P < 0.01) in cTnI and CK-MB concentrations were observed in G4 and G8. No changes (P > 0.05) in lactate concentration were observed post-cavalcade in all groups. Power tests values were 1.0 for cTnI and CK-MB, 0.63 for lactate. Positive correlations (0.4 < r < 0.5) were observed between cTnI and CK-MB. The changes in cTnI and CK-MB concentrations post-exercise is indicative of myocardial cell injury in healthy Mangalarga Marchador horses, which could be considered as an adaptation to physical exercise.

show abstract

“…Both supraventricular and ventricular premature beats have raised concerns in equine cardiology as potential initiators of atrial fibrillation [2] and fatal ventricular arrhythmias [3]. In recent years, studies have therefore investigated the occurrence of premature beats in healthy horses [4–8], horses with poor performance [9, 10], and in both clinical [11, 12] and experimental settings [13]. These studies provide valuable information on the prevalence of premature beats, although a comparison of the results is problematic due to different study designs.…”

Section: Introductionmentioning

confidence: 99%

Appropriate threshold levels of cardiac beat-to-beat variation in semi-automatic analysis of equine ECG recordings

et al. 2016

View full text Add to dashboard Cite

BackgroundAlthough premature beats are a matter of concern in horses, the interpretation of equine ECG recordings is complicated by a lack of standardized analysis criteria and a limited knowledge of the normal beat-to-beat variation of equine cardiac rhythm. The purpose of this study was to determine the appropriate threshold levels of maximum acceptable deviation of RR intervals in equine ECG analysis, and to evaluate a novel two-step timing algorithm by quantifying the frequency of arrhythmias in a cohort of healthy adult endurance horses.ResultsBeat-to-beat variation differed considerably with heart rate (HR), and an adaptable model consisting of three different HR ranges with separate threshold levels of maximum acceptable RR deviation was consequently defined. For resting HRs <60 beats/min (bpm) the threshold level of RR deviation was set at 20%, for HRs in the intermediate range between 60 and 100 bpm the threshold was 10%, and for exercising HRs >100 bpm, the threshold level was 4%. Supraventricular premature beats represented the most prevalent arrhythmia category with varying frequencies in seven horses at rest (median 7, range 2–86) and six horses during exercise (median 2, range 1–24).ConclusionsBeat-to-beat variation of equine cardiac rhythm varies according to HR, and threshold levels in equine ECG analysis should be adjusted accordingly. Standardization of the analysis criteria will enable comparisons of studies and follow-up examinations of patients. A small number of supraventricular premature beats appears to be a normal finding in endurance horses. Further studies are required to validate the findings and determine the clinical significance of premature beats in horses.

show abstract

Cardiac troponin I and the occurrence of cardiac arrhythmias in horses with experimentally induced endotoxaemia

Cited by 43 publications

References 34 publications

Prognostic Value of Cardiac Troponin I and L‐Lactate in Blood of Dairy Cows Affected by Downer Cow Syndrome

Prognostic Value of Cardiac Troponin I and L‐Lactate in Blood of Dairy Cows Affected by Downer Cow Syndrome

Influence of Cavalcade of Different Distances on the Serum Concentrations of the Cardiac Biomarkers Troponin I (Ctni) and Creatine Kinase Myocardial Band (CK-MB) in Horses

Appropriate threshold levels of cardiac beat-to-beat variation in semi-automatic analysis of equine ECG recordings

Contact Info

Product

Resources

About