Cardiac troponin I and beta 2 microglobulin as risk factors for early‐onset atherosclerosis in patients on haemodialysis

Abstract

Besides well-known cardiovascular (CV) risk factors, cTnI and beta2M were related with C-IMT in that they may have important roles in early-onset atherosclerosis in this high-risk population.

Differences in associated factors between aortic and mitral valve calcification in hemodialysis

“…18 In patients on HD, serum b 2 M is markedly increased and predicts all-cause mortality, 19,20 but studies on the relationship between serum b 2 M and cardiovascular disease are limited. It has been reported that serum b 2 M correlates with carotid IMT 21 and the number of calcified valves. 6 Serum b 2 M indicates the clearance of middle molecules by HD, or may be related to inflammation, as suggested by some authorities.…”

Determinants of Cardiovascular Risk in Hemodialysis Patients Without Significant Comorbidities

“…The mean serum cardiac troponin I level in the control group was significantly lower than it was in patients both with and without left ventricular hypertrophy. The mean serum cardiac troponin I level was significantly higher in patients with left ventricular hypertrophy than it was in those without left ventricular hypertrophy (Zumrutdal et al, 2005). The relationship between carotid artery intima-media thickness, serum cardiac troponin I levels and left ventricular hypertrophy may demonstrate that subclinical atherosclerotic changes and/or adaptation may occur along with cardiac alterations.…”

“…Supporting that study, while no relationship between ESR and carotid artery intima-media thickness was found, a relationship in hemodialysis patients without comorbidities was found between Hctcorrected ESR and carotid artery intima-media thickness, beyond other inflammatory markers, CRP, and fibrinogen. Although larger additional studies are needed to determine the potential value of Hct-corrected ESR as an inflammatory marker for early-onset atherosclerosis, this relationship may again reflect the role of non-specific inflammation in CV risk of the 'healthy' hemodialysis patients ( Zumrutdal et al, 2005).…”

“…So the clear association between CRP and CV disease in the hemodialysis population has added CRP as a new predictive CV risk factor which may actually be in a midway position between traditional and uremia-related CV risk factors (Arici&Walls, 2001). One of the studies investigated the associations of different risk factors with carotid artery intima-media thickness in non-diabetic hemodialysis patients who had no clinical evidence of atherosclerosis and no comorbidities (Zumrutdal et al, 2005). Seventy-two patients (43 men, 29 women; mean age 34.5 ± 10.6 years, mean time on hemodialysis 47.9 ± 40.0 months) were included in the study.…”

“…The presence of generalized endothelial dysfunction in uraemic patients is also suggested by higher plasma levels of fibrinogen, endothelin and other factors. The relationship between carotid artery intimamedia thickness and fibrinogene in hemodialysis patients without comorbidities may reflect the role of fibrinogene in early-onset atherosclerosis as one of the best-studied inflammation markers (Zumrutdal et al, 2005).…”