Cardiac tissue engineering, biomaterial scaffolds, and their fabrication techniques

Roshandel, Marjan; Dorkoosh, Farid Abedin

doi:10.1002/pat.5273

Cited by 30 publications

(26 citation statements)

References 158 publications

(191 reference statements)

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“…Any biomaterial designed for cardiac tissue engineering should possess key properties to prevent the dilation of cardiac muscle, avoid or slow scar formation and fibrosis, while favoring the integration and proliferation of cardiomyocytes [ 24 ].…”

Section: Biomaterials For Cardiac Regenerationmentioning

confidence: 99%

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Polymeric Biomaterials for the Treatment of Cardiac Post-Infarction Injuries

et al. 2021

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Cardiac regeneration aims to reconstruct the heart contractile mass, preventing the organ from a progressive functional deterioration, by delivering pro-regenerative cells, drugs, or growth factors to the site of injury. In recent years, scientific research focused the attention on tissue engineering for the regeneration of cardiac infarct tissue, and biomaterials able to anatomically and physiologically adapt to the heart muscle have been proposed as valuable tools for this purpose, providing the cells with the stimuli necessary to initiate a complete regenerative process. An ideal biomaterial for cardiac tissue regeneration should have a positive influence on the biomechanical, biochemical, and biological properties of tissues and cells; perfectly reflect the morphology and functionality of the native myocardium; and be mechanically stable, with a suitable thickness. Among others, engineered hydrogels, three-dimensional polymeric systems made from synthetic and natural biomaterials, have attracted much interest for cardiac post-infarction therapy. In addition, biocompatible nanosystems, and polymeric nanoparticles in particular, have been explored in preclinical studies as drug delivery and tissue engineering platforms for the treatment of cardiovascular diseases. This review focused on the most employed natural and synthetic biomaterials in cardiac regeneration, paying particular attention to the contribution of Italian research groups in this field, the fabrication techniques, and the current status of the clinical trials.

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Section: Biomaterials For Cardiac Regenerationmentioning

confidence: 99%

“…The available techniques for the fabrication of cardiac scaffolds can be divided into conventional and non-conventional methods. The first group includes solvent casting/particulate leaching, thermally-induced phase separation, electrospinning, gas foaming, and freeze drying [ 24 , 51 ].…”

Section: Cardiac Scaffolds Fabrication Techniquesmentioning

confidence: 99%

Polymeric Biomaterials for the Treatment of Cardiac Post-Infarction Injuries

et al. 2021

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“…Further, many studies focus on vascularization of the cardiac organoids to overcome the lack of oxygen and nutrient diffusion, by coating the organoids with an extracellular matrix containing endothelial cells [ 297 ], cultured cardiac organoids with hPSC-derived endothelial cells [ 298 ], and fusion of two subregional organoids to form a complete organ [ 299 ]. Moreover, cardiac tissue engineering field has rapidly evolved over the past decade and offers a biomedicine discipline attempting to combine scaffolding polymers with cardiovascular cells to create cardiac tissue-like structures for drug screening, disease modeling, and cardiac repair [ 300 , 301 , 302 , 303 , 304 , 305 ]. Interestingly, the use of heart-on-a-chip models has recently increased, providing a controllable tool, mean oxygen delivery [ 306 , 307 , 308 , 309 ], pH [ 308 ], shear stress with a certain flow rate of the culture medium [ 310 , 311 ], temperature control, and electrical or mechanical stimulation, as well as continuous monitoring and measurement of parameters of the physiological responses of the cells.…”

Section: Consideration Of Hipsc For Use In Modeling Heart Diseasementioning

confidence: 99%

Human Induced Pluripotent Stem Cell as a Disease Modeling and Drug Development Platform—A Cardiac Perspective

Bekhite

Schulze

2021

Cells

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A comprehensive understanding of the pathophysiology and cellular responses to drugs in human heart disease is limited by species differences between humans and experimental animals. In addition, isolation of human cardiomyocytes (CMs) is complicated because cells obtained by biopsy do not proliferate to provide sufficient numbers of cells for preclinical studies in vitro. Interestingly, the discovery of human-induced pluripotent stem cell (hiPSC) has opened up the possibility of generating and studying heart disease in a culture dish. The combination of reprogramming and genome editing technologies to generate a broad spectrum of human heart diseases in vitro offers a great opportunity to elucidate gene function and mechanisms. However, to exploit the potential applications of hiPSC-derived-CMs for drug testing and studying adult-onset cardiac disease, a full functional characterization of maturation and metabolic traits is required. In this review, we focus on methods to reprogram somatic cells into hiPSC and the solutions for overcome immaturity of the hiPSC-derived-CMs to mimic the structure and physiological properties of the adult human CMs to accurately model disease and test drug safety. Finally, we discuss how to improve the culture, differentiation, and purification of CMs to obtain sufficient numbers of desired types of hiPSC-derived-CMs for disease modeling and drug development platform.

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“…Particulate leaching has been employed in tissue engineering since it is one of the simplest methods used to create porous materials using salt. The method of salt leaching is simple and does not need the use of high pressure or expensive equipment [18][19][20]. Controlling of porosity, pore structure, and pore size is as easy as changing the quantity and particle size of salt.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Polycaprolactone/Carboxymethyl Cellulose Scaffolds by Mechanical and Thermal Analysis

Sriputtha¹,

Wiwatwongwana²,

Promma

2022

Eng. Technol. Appl. Sci. Res.

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The objective of this work was to learn more about three-dimensional porous scaffolds made from biomaterial based on polycaprolactone (PCL) containing different amounts of carboxymethyl cellulose (CMC) nanoparticles. Composite material samples containing 0, 2, 6.5, 11, 15.5, and 20% w/w of CMC and PCL/CMC scaffolds were prepared with the use of the salt particle leached technique. The mechanical properties were evaluated with the compressive strength analysis method. The studied temperature range started at very low temperatures and ended at crosslinking temperatures. It was evaluated using the thermal analysis methods of Differential Scanning Calorimetry (DSC) in the range 0ºC-200ºC. The results revealed that the compressive modulus of blended PCL/CMC scaffold was higher than the one of pure PCL scaffold (582.2±106.2 kPa for pure PCL scaffold and 612.2±296 kPa for blended scaffold which contained 20% of CMC). For DSC analysis, in addition to the 15.5% w/w CMC PCL/CMC composite scaffold, other proportions of composite materials showed a decrease in crystallization temperature. The crystallinity of PCL-20% CMC was higher than that of PCL scaffolds.

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Cardiac tissue engineering, biomaterial scaffolds, and their fabrication techniques

Cited by 30 publications

References 158 publications

Polymeric Biomaterials for the Treatment of Cardiac Post-Infarction Injuries

Polymeric Biomaterials for the Treatment of Cardiac Post-Infarction Injuries

Human Induced Pluripotent Stem Cell as a Disease Modeling and Drug Development Platform—A Cardiac Perspective

Investigation of Polycaprolactone/Carboxymethyl Cellulose Scaffolds by Mechanical and Thermal Analysis

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