Cardiac Thyrotropin-releasing Hormone Inhibition Improves Ventricular Function and Reduces Hypertrophy and Fibrosis After Myocardial Infarction in Rats

Schuman, Mariano Luis; Diaz, Ludmila Soledad Peres; Aisicovich, Maia; Ingallina, Fernando Juan; Toblli, Jorge Eduardo; Landa, María Silvina; Garcı́a, Silvia

doi:10.1016/j.cardfail.2021.04.003

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…TRH is a cardiac hormone that has important functions in heart regulation and the responses to cardiac stress. It is induced after myocardial infarction and serves as a positive inotrope increasing cardiac contractility and output, but long-term activation can lead to a hypertrophic phenotype in the heart [42][43][44][45] . To further interpret the gene expression data and enhance the GO analysis, a hallmark gene set analysis was conducted with female-derived hiPSC-CMs as a reference.…”

Section: Gene Ontology Pathways Enrichment Reveals Sex Differences In...mentioning

confidence: 99%

Healthy human induced pluripotent stem cell-derived cardiomyocytes exhibit sex dimorphism even without the addition of hormones

Givens,

Andebrhan,

Schmuck

et al. 2024

Preprint

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Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a valuable cell type for studying human cardiac health and diseasein vitro. However, it is not known whether hiPSC-CM display sex dimorphism and therefore whether sex should be incorporated as a biological variable inin vitrostudies that include this cell type. To date, the vast majority of studies that utilize hiPSC-CM do not include both male and female sex nor stratify results based on sex because it is challenging to amass such a cohort of cells. Here we generated three female and three male hiPSC-lines from adult left ventricular cardiac fibroblasts as a resource for studying sex differences inin vitrocardiac models. We used this resource to generate hiPSC-CM and maintained them in basal media without exogenous hormones. Functional assessment of CM showed enhanced calcium handling in female-derived hiPSC-CM relative to male. Bulk RNA sequencing revealed over 300 differentially expressed genes (DEG) between male and female hiPSC-CM. Some of the DEG are X and Y-linked genes and many are implicated in cardiac health and disease including potassium channels which could account for net differences in calcium handling shown here. Gene ontology analysis of DEG showed distinct differences in pathways related to cardiac pathology including cell-cell adhesion, metabolic processes, and response to ischemic stress. These findings highlight the importance of considering sex as a variable when conducting studies to evaluate aspects of human cardiac health and disease related to cardiomyocyte function.

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Section: Gene Ontology Pathways Enrichment Reveals Sex Differences In...mentioning

confidence: 99%

Healthy human induced pluripotent stem cell-derived cardiomyocytes exhibit sex dimorphism even without the addition of hormones

Givens,

Andebrhan,

Schmuck

et al. 2024

Preprint

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show abstract

“…Following, we summarize the recent studies about amino acids and nucleotides. The inhibition of cardiac thyrotropin-releasing hormone reduces post-infarct hypertrophy and fibrosis ( Schuman et al, 2021 ). Additionally, triiodothyronine pretreatment improves post-MI dysfunction and inhibits fibrosis by activating the insulin-like growth factor-1/PI3K/Akt signaling pathway ( Zeng et al, 2021 ).…”

Section: Interventions For Cardiac Fibrosismentioning

confidence: 99%

Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention

Yin

Pan

et al. 2023

Front. Pharmacol.

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Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and extracellular matrix collagen deposition are the hallmarks of cardiac fibrosis, which are modulated by multiple signaling pathways and various types of cells in time-dependent manners. Our understanding of the development of cardiac fibrosis after MI has evolved in basic and clinical researches, and the regulation of fibrotic remodeling may facilitate novel diagnostic and therapeutic strategies, and finally improve outcomes. Here, we aim to elaborate pathophysiology, examination and intervention of cardiac fibrosis after MI.

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Novel Leptin-Cardiac TRH pathway responsible for the cardiac alterations in the Hyperleptinemic obesity

Peres Díaz,

Aisicovich,

Schuman

et al. 2024

Mol Cell Biochem

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Cardiac Thyrotropin-releasing Hormone Inhibition Improves Ventricular Function and Reduces Hypertrophy and Fibrosis After Myocardial Infarction in Rats

Cited by 4 publications

References 34 publications

Healthy human induced pluripotent stem cell-derived cardiomyocytes exhibit sex dimorphism even without the addition of hormones

Healthy human induced pluripotent stem cell-derived cardiomyocytes exhibit sex dimorphism even without the addition of hormones

Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention

Novel Leptin-Cardiac TRH pathway responsible for the cardiac alterations in the Hyperleptinemic obesity

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