Cardiac thrombosis and thromboembolism in chronic chagas' heart disease

Oliveira, João Samuel Meira de; Araujo, Rosaly R. Correa De; Navarro, Marcos André; Muccillo, Gerson

doi:10.1016/0002-9149(83)90085-1

Cited by 140 publications

(65 citation statements)

References 17 publications

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“…It is important to emphasize that all the anatomical and functional disturbances detected during life are consistent with the autopsy findings reported on several series of chagasic patients who died in the various stages of the disease 43,44,49,50 .…”

Section: Clinical Features Of Chagas' Heart Diseasesupporting

confidence: 83%

“…However, evidence from postmortem studies suggests that emboli are often overlooked. In a review of 1345 autopsy cases, the incidence of cardiac thrombus or thromboemboli was 44 percent; the right and left cardiac chambers were equally affected 50 . Although thromboembolic phenomena were more common in the systemic circulation, pulmonary embolism accounted for 14 percent of deaths.…”

Section: Clinical Features Of Chagas' Heart Diseasementioning

confidence: 99%

“…Intracardiac mural thrombosis in various stages of organization is found in nearly 50% of such cases; the right and left heart chambers are equally affected 50 . The most specific cardiac anatomic lesion is the ventricular apical aneurysm which, in one series, was noted in 52 percent of 1078 autopsied chagasic patients 88 .…”

Section: Pathological Abnormalitiesmentioning

confidence: 99%

See 2 more Smart Citations

Chagas' heart disease

Marin-Neto¹,

Simões²,

Sarabanda³

1999

Arq. Bras. Cardiol.

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Section: Clinical Features Of Chagas' Heart Diseasesupporting

confidence: 83%

Section: Clinical Features Of Chagas' Heart Diseasementioning

confidence: 99%

See 1 more Smart Citation

Chagas' heart disease

Marin-Neto¹,

Simões²,

Sarabanda³

1999

Arq. Bras. Cardiol.

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“…8 Alternatively, autonomic neuronal dysfunction may predominate with resulting "megasyndromes" that usually involve the large bowel or esophagus but possibly any other tubular organ. Whether manifest as cardiac syndromes, megasyndromes, or a combination, a noteworthy clinical aspect of CCM is the paucity of parasites in the myocardium.…”

Section: Chronic Chagas' Cardiomyopathy Inmentioning

confidence: 99%

Pathophysiological insights into the cardiomyopathy of Chagas' disease.

et al. 1990

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The evidence gained from both human and animal studies of chronic chagasic cardiomyopathy suggests that the disease occurs as a consequence of several discrete and progressive pathophysiological processes occurring after infection, the ultimate expression of which depends on a host of unidentified factors. Collectively, the infection-associated events compromise microvasculature function and result in hypoperfusion, with consequences indistinguishable from those observed in other, nonparasitological cardiomyopathic diseases secondary to hypoperfusion. Therefore, chronic chagasic cardiomyopathy may share similar pathophysiological abnormalities with other chronic congestive cardiomyopathic states.

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“…6,9 There is dilatation of the sinusoids, microscopic hemorrhages, and, over the long term, fibrosis of Billroth's cords and a certain degree of atrophy of the lymphoid follicles. 7 There are few reports of spleen involvement in the chronic phase of Chagas' disease, and they generally refer to thromboembolic phenomena [10][11][12][13][14] or weight alterations. 15 Because Chagas' disease is an infectious disease that has an inflammatory response as one of its basic lesions, with the possibility of presenting hemodynamic repercussions, we raised the hypothesis that alterations capable of objective evaluation via morphometry could exist in these circumstances.…”

Section: Introductionmentioning

confidence: 99%