Cardiac telocytes. From basic science to cardiac diseases. II. Acute myocardial infarction

Hostiuc, Sorin; Marinescu, Mihai; Costescu, M; Aluaș, Maria; Negoi, Ionuț

doi:10.1016/j.aanat.2018.02.008

Cited by 9 publications

(7 citation statements)

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“…We demonstrated the absence of convincing scientific proof of potential correlation between the presence of cardiac TCs and both disorders. Moreover, we showed that the citing articles often took certain implied discussions/conclusions from original articles in the field and considered them to be objective proof of the role of cardiac TCs in either atrial fibrillation or myocardial infarction [Hostiuc et al, 2018a. Therefore, the potential role of these structures in various cardiac pathologies was questioned.…”

Section: Tc Markersmentioning

confidence: 99%

“…In a couple of recent articles [Hostiuc et al, 2018a, we have re-reviewed the potential roles of cardiac TCs in both atrial fibrillation and myocardial infarction, as presented/implied in various original research articles. We demonstrated the absence of convincing scientific proof of potential correlation between the presence of cardiac TCs and both disorders.…”

Section: Tc Markersmentioning

confidence: 99%

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Myocardial Telocyte-Like Cells: A Review Including New Evidence

Iancu

Rusu

Mogoantă

et al. 2018

Cells Tissues Organs

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Telocytes (TCs) are a controversial cell type characterized by the presence of a particular kind of prolongations, known as telopodes, which are long, thin, and moniliform. A number of attempts has been made to establish the molecular phenotype of cardiac TCs (i.e., expression of c-kit, CD34, vimentin, PDGRFα, PDGRFβ, etc.). We designed an immunohistochemical study involving cardiac tissue samples obtained from 10 cadavers with the aim of determining whether there are TC-like interstitial cells that populate the interstitial space other than the mural microvascular cells. We applied the markers for CD31, CD34, PDGRFα, CD117/c-kit, and α-smooth muscle actin (α-SMA). We found that, in relation to two-dimensional cuts, the endothelial tubes could be misidentified as TC-like cells, the difference being the positive identification of endothelial lumina. Moreover, we found that cardiac pericytes express PDGRFα, CD117/c-kit, and α-SMA, and that they could also be misidentified as TCs when using light microscopy. We reviewed the respective values of the previously identified markers for achieving a clear-cut identification of cardiac TCs, highlighting the critical lack of specificity.

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Section: Tc Markersmentioning

confidence: 99%

Section: Tc Markersmentioning

confidence: 99%

Myocardial Telocyte-Like Cells: A Review Including New Evidence

Iancu

Rusu

Mogoantă

et al. 2018

Cells Tissues Organs

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“…It has been reported that telocytes are present in many layers of the heart, (Bani et al, 2010; Popescu et al, 2010; Rusu et al, 2017; Yang et al, 2014; Zhou et al, 2015), with more cells in the atria than in the ventricles and in the subepicardium than the endocardium (Liu et al, 2011). Telocytes give immunopositive reactions with many immunostaining markers, such as c‐kit, CD34, PDGFR‐α, PDGFR‐β, vimentin, EGFR, tau, SMA, S100, connexin, caveolin, and sca‐1 (Chang et al, 2015; Hinescu et al, 2006; Hostiuc, Marinescu, Costescu, Aluaș, & Negoi, 2018; Suciu et al, 2010; Zhou et al, 2015). In some studies, only the CD34 or c‐kit immunopositive cells were accepted as telocytes (Hostiuc et al, 2018; Nour, Sarhan, Mazroa, & Gawish, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Telocytes give immunopositive reactions with many immunostaining markers, such as c‐kit, CD34, PDGFR‐α, PDGFR‐β, vimentin, EGFR, tau, SMA, S100, connexin, caveolin, and sca‐1 (Chang et al, 2015; Hinescu et al, 2006; Hostiuc, Marinescu, Costescu, Aluaș, & Negoi, 2018; Suciu et al, 2010; Zhou et al, 2015). In some studies, only the CD34 or c‐kit immunopositive cells were accepted as telocytes (Hostiuc et al, 2018; Nour, Sarhan, Mazroa, & Gawish, 2017). However, it has been reported that double immunostaining should be performed to separate telocytes from other cells, due to their wide immunophenotypic characteristics (Cretoiu & Popescu, 2014; Sheng et al, 2014; Suciu et al, 2009; Zhou et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Telocytes in the hearts of Saanen goats

Sizer

Kabak

2020

Microscopy Res & Technique

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Telocytes, new interstitial cells that have received significant attention in recent years, have been detected in many organs, including the heart. The distinction between telocytes and other interstitial cells can only be made based on their ultrastructural characterization and immunophenotypic features. In this study, we examined the interstitial cells in the healthy heart tissues of Saanen goats to determine whether they are telocytes or not, by using a scanning electron microscope (SEM) and immunohistochemical and immunofluorescence staining methods. The SEM revealed oval and round telocytes with two to four telopodes. Some telopodes also had podoms. The staining for immunohistochemical and immunofluorescence methods used for CD34, c‐kit (CD117), and vimentin antibodies. Positive cells were detected in the heart muscle and heart valves by immunohistochemical staining. As these antigens can also be expressed by other non‐telocyte cells, we used double immunofluorescence staining with CD34/c‐kit and CD34/vimentin antibodies to identify true telocytes. Telocytes were determined in the right atrium and aortic valve. While telocytes were CD34+/c‐kit+ and CD34+/vimentin+, fibroblasts were CD34−/vimentin+. These results confirm the presence of telocytes in the hearts of Saanen goats.

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“…Telocytes have also been repeatedly described in the muscle tissue [40], with the bulk of attention focused on the myocardium. Interestingly, their function in the heart was shown to be considerably different from that of telocytes in other organs [41,42,43]. Recent research indicated that the subepicardial layer of the heart contains cardiogenic stem cell niches.…”

Section: Telocytes As Principal Cells Of Diverse Organs Of the Hummentioning

confidence: 99%

Recently Discovered Interstitial Cell Population of Telocytes: Distinguishing Facts from Fiction Regarding Their Role in the Pathogenesis of Diverse Diseases Called “Telocytopathies”

et al. 2019

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In recent years, the interstitial cells telocytes, formerly known as interstitial Cajal-like cells, have been described in almost all organs of the human body. Although telocytes were previously thought to be localized predominantly in the organs of the digestive system, as of 2018 they have also been described in the lymphoid tissue, skin, respiratory system, urinary system, meninges and the organs of the male and female genital tracts. Since the time of eminent German pathologist Rudolf Virchow, we have known that many pathological processes originate directly from cellular changes. Even though telocytes are not widely accepted by all scientists as an individual and morphologically and functionally distinct cell population, several articles regarding telocytes have already been published in such prestigious journals as Nature and Annals of the New York Academy of Sciences. The telocyte diversity extends beyond their morphology and functions, as they have a potential role in the etiopathogenesis of different diseases. The most commonly described telocyte-associated diseases (which may be best termed “telocytopathies” in the future) are summarized in this critical review. It is difficult to imagine that a single cell population could be involved in the pathogenesis of such a wide spectrum of pathological conditions as extragastrointestinal stromal tumors (“telocytomas”), liver fibrosis, preeclampsia during pregnancy, tubal infertility, heart failure and psoriasis. In any case, future functional studies of telocytes in vivo will help to understand the mechanism by which telocytes contribute to tissue homeostasis in health and disease.

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Cardiac telocytes. From basic science to cardiac diseases. II. Acute myocardial infarction

Cited by 9 publications

References 50 publications

Myocardial Telocyte-Like Cells: A Review Including New Evidence

Myocardial Telocyte-Like Cells: A Review Including New Evidence

Telocytes in the hearts of Saanen goats

Recently Discovered Interstitial Cell Population of Telocytes: Distinguishing Facts from Fiction Regarding Their Role in the Pathogenesis of Diverse Diseases Called “Telocytopathies”

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