Cardiac telocytes as principal interstitial cells for myocardial reparation and regeneration after infarction – our hope

Varga, Ivan; Kyselovič, Ján; Danihel, L; Klein, Martin; Barczi, Tomas; Gálfiová, Paulína; Danišovič, Ľuboš

doi:10.4149/bll_2017_136

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…In terms of the physiological growth of the heart and the effects of exercise, most research focused solely on cardiomyocytes, while exercise is also effective in stimulating healthy heart growth on other types of heart cells [ 42 , 43 ]. Among these cells are the lesser known telocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown a decrease in the number of cardiac telocytes in the infarcted zone following myocardial infarction [ 22 , 42 , 43 , 49 , 51 ] and transplantation of telocytes to the heart with myocardial infarction reduces the size of the infarction and improves myocardial function [ 3 , 22 , 42 , 43 , 50 , 51 ]. Cardiac telocytes also help regenerate the heart’s interstitial network and maintain myocardial function, which can be important in providing the right microenvironment for the migration and development of heart stem cells [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Telocytes response to cardiac growth induced by resistance exercise training and endurance exercise training in adult male rats

Choobineh¹,

Fard²,

Soori³

et al. 2023

J Physiol Sci

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Telocytes are interstitial cells found in different tissues, including cardiac stem cell niches. The purpose of this study was to investigate the response of the telocytes to the cardiac growth that occurs in response to resistance and endurance exercise trainings using rats distributed into control, endurance, and resistance training groups. Results revealed that the ratio of heart weight to body weight, cardiomycyte number, cardiomyocyte area, thickness of the left ventricular wall were significantly higher in the training groups compared to the control group. We observed increment in the cardiomyocytes surface area and thickness of the left ventricular wall in the resistance-training group than endurance-training group. We conclude that both resistance and endurance exercise trainings will lead to an increased number of cardiac telocytes, consequently, promote activity of the cardiac stem cells, and results in physiological cardiac growth, and this response does not seem to depend on the type of exercise.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Telocytes response to cardiac growth induced by resistance exercise training and endurance exercise training in adult male rats

Choobineh¹,

Fard²,

Soori³

et al. 2023

J Physiol Sci

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“…The role of telocytes in myocardial regeneration in humans (in contrast to animal models) remains questionable. Although telocyte numbers were shown to be reduced in end-stage failing hearts [46], in our previous study we found no link between telocyte numbers and the dynamics of the reparative mechanisms in the human heart after myocardial infarction [47].…”

Section: Telocytes As Principal Cells Of Diverse Organs Of the Hummentioning

confidence: 90%

Recently Discovered Interstitial Cell Population of Telocytes: Distinguishing Facts from Fiction Regarding Their Role in the Pathogenesis of Diverse Diseases Called “Telocytopathies”

et al. 2019

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In recent years, the interstitial cells telocytes, formerly known as interstitial Cajal-like cells, have been described in almost all organs of the human body. Although telocytes were previously thought to be localized predominantly in the organs of the digestive system, as of 2018 they have also been described in the lymphoid tissue, skin, respiratory system, urinary system, meninges and the organs of the male and female genital tracts. Since the time of eminent German pathologist Rudolf Virchow, we have known that many pathological processes originate directly from cellular changes. Even though telocytes are not widely accepted by all scientists as an individual and morphologically and functionally distinct cell population, several articles regarding telocytes have already been published in such prestigious journals as Nature and Annals of the New York Academy of Sciences. The telocyte diversity extends beyond their morphology and functions, as they have a potential role in the etiopathogenesis of different diseases. The most commonly described telocyte-associated diseases (which may be best termed “telocytopathies” in the future) are summarized in this critical review. It is difficult to imagine that a single cell population could be involved in the pathogenesis of such a wide spectrum of pathological conditions as extragastrointestinal stromal tumors (“telocytomas”), liver fibrosis, preeclampsia during pregnancy, tubal infertility, heart failure and psoriasis. In any case, future functional studies of telocytes in vivo will help to understand the mechanism by which telocytes contribute to tissue homeostasis in health and disease.

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“…Multiple studies have demonstrated that the normal function and morphology of cardiac TCs are severely disrupted during myocardial infarction [45,49,50]. At first glance, this finding is not very surprising, given that the myocardial ischemia, with subsequent apoptosis, necrosis, and overall derangement of the cellular microenvironment, alters all the cell populations in the affected site, including TCs.…”

Section: Myocardial Infarctionmentioning

confidence: 99%

Cardiac Telocytes 16 Years on—What Have We Learned So Far, and How Close Are We to Routine Application of the Knowledge in Cardiovascular Regenerative Medicine?

Klein

Csöbönyeiová

Žiaran

et al. 2021

IJMS

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The regeneration of a diseased heart is one of the principal challenges of modern cardiovascular medicine. There has been ongoing research on stem-cell-based therapeutic approaches. A cell population called telocytes (TCs) described only 16 years ago largely contributed to the research area of cardiovascular regeneration. TCs are cells with small bodies and extremely long cytoplasmic projections called telopodes, described in all layers of the heart wall. Their functions include cell-to-cell signaling, stem-cell nursing, mechanical support, and immunoregulation, to name but a few. The functional derangement or quantitative loss of TCs has been implicated in the pathogenesis of myocardial infarction, heart failure, arrhythmias, and many other conditions. The exact pathomechanisms are still unknown, but the loss of regulative, integrative, and nursing functions of TCs may provide important clues. Therefore, a viable avenue in the future modern management of these conditions is TC-based cell therapy. TCs have been previously transplanted into a mouse model of myocardial infarction with promising results. Tandem transplantation with stem cells may provide additional benefit; however, many underresearched areas need to be addressed in future research before routine application of TC-based cell therapy in human subjects. These include the standardization of protocols for isolation, cultivation, and transplantation, quantitative optimization of TC transplants, cost-effectivity analysis, and many others.

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Cardiac telocytes as principal interstitial cells for myocardial reparation and regeneration after infarction – our hope

Abstract: According to our knowledge, this is the first research experiment that focuses on the study of the distribution of c-kit positive cells at the sites of myocardial infarction in human hearts (Fig. 3, Ref. 16).

Cited by 4 publications

References 10 publications

Telocytes response to cardiac growth induced by resistance exercise training and endurance exercise training in adult male rats

Telocytes response to cardiac growth induced by resistance exercise training and endurance exercise training in adult male rats

Recently Discovered Interstitial Cell Population of Telocytes: Distinguishing Facts from Fiction Regarding Their Role in the Pathogenesis of Diverse Diseases Called “Telocytopathies”

Cardiac Telocytes 16 Years on—What Have We Learned So Far, and How Close Are We to Routine Application of the Knowledge in Cardiovascular Regenerative Medicine?

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