Cardiac Tamponade Associated with Human Immunodeficiency Virus-Associated Immune Complex Kidney Disease

Farouji, Iyad; Damati, Ahmad; Chan, Kok Hoe; Chenitz, Kara; Slim, Jihad; Shamoon, Fayez

doi:10.4103/jgid.jgid_226_20

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Immunodeficiency may be accompanied by cardiac tamponade; however, it is not common. Farouji et al reported a 35-year-old woman with immune deficiency presented with cardiac tamponade [ 14 ]. Our patient had a massive pericardial effusion that could have led to tamponade, but her early diagnosis saved her life.…”

Section: Discussionmentioning

confidence: 99%

Immunodeficiency due to a novel variant in PIK3CD: a case report

Shashaani,

Chavoshzadeh,

Ghasemi

et al. 2023

Pediatr Rheumatol

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Background Primary immunodeficiencies are immunological disorders caused by gene mutations involved in immune system development and activation. Recently, activated phosphoinositide 3-kinase delta syndrome (APDS) due to mutations in the phosphoinositide 3-kinase (PI3K), phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit delta gene (PIK3CD), and phosphoinositide 3-kinase regulatory subunit 1 (PIK3R1) genes have been reported to induce a combined immunodeficiency syndrome leading to senescent T cells, lymphadenopathy, and immunodeficiency. The exact diagnosis of these deficiencies is essential for treatment and prognosis. In recent years, targeted treatment with selective PI3Kd inhibitors has had a significant effect on controlling the symptoms of these patients. Case presentation In this case report, we represent a 27-month-old girl with recurrent fever, an increased level of inflammatory markers, and erythema nodosum, who was referred to the rheumatology clinic. In the course of evaluations, because of the lack of clinical improvement with usual treatments, and a history of frequent respiratory infections, combined immunodeficiency was diagnosed in the immunological investigations. Moreover, whole-exome sequencing was performed for her. Conclusion The genetic analysis found a novel variant of PIK3CD (c.1429 G > A) in the patient. Following daily antibiotic prophylaxis and monthly IV therapy, the patient’s frequent infections and fevers were controlled.

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Section: Discussionmentioning

confidence: 99%