Cardiac Tamponade After COVID-19 Vaccination

Abstract

Background Acute pericarditis is a diffuse inflammation of the pericardial sac with many well-defined etiologies. Acute pericarditis as a vaccine-related adverse event is a rare entity and the association between pericarditis and the immunogenic response to COVID-19 vaccines is still being fully characterized. Case Report A previously healthy 18-year-old male presented with fever, pleuritic chest pain, and shortness of breath shortly after receiving the first dose of a COVID-19 mRNA-based vaccine. The patient was found to have a large pericardial effusion with early tamponade physiology requiring pericardiocentesis. Why Should an Emergency Physician Be Aware of This : As COVID-19 vaccination becomes more prevalent globally, physicians should be aware of pericarditis as a rare but potentially serious adverse reaction.

Acute Polyserositis with Cardiac Tamponade and Bilateral Refractory Pleural Effusion after ChAdOx1 nCoV-19 Vaccination

“…For the SARS-CoV-2 pandemic, different types of vaccine are currently available. Increasing concerns about pericarditis and/or myocarditis following the mRNA vaccine injection have been raised [1][2][3][4]. Of note, COVID-19 vaccine-related cardiac involvement usually presents in young men [8][9][10].…”

“…Despite the fact that the benefit of the SARS-CoV-2 vaccine outweighs the risk, more and more adverse events have been reported. The association of SARS-CoV-2 messenger ribonucleic acid (mRNA) vaccines (Pfizer-BioNTech and Moderna) with pericarditis and myocarditis in young adults has been reported, particularly for male adolescents [1][2][3][4]. However, data regarding other types of coronavirus disease 2019 (COVID-19) vaccines, such as the viral vector vaccines, are extremely limited.…”

Cardiac Tamponade and COVID-19 Vaccination: Correspondence

“…Email: pathumsook@gmail.com Dear Editor, we would like to share ideas on the publication "Cardiac Tamponade After COVID-19 Vaccination [1]." Hryniewicki et al concluded that "Although a direct causal link cannot be demonstrated, we present this case to increase awareness among emergency physicians of pericarditis as a rare, but potentially serious adverse event associated with COVID-19 vaccination.…”

“…Hryniewicki et al concluded that "Although a direct causal link cannot be demonstrated, we present this case to increase awareness among emergency physicians of pericarditis as a rare, but potentially serious adverse event associated with COVID-19 vaccination. [1]." We agree that the COVID-19 vaccine might induce some adverse event and cardiac tamponade is possible.…”

Large Hemorrhagic Pericardial Effusion and Cardiac Tamponade Following BNT162b2 (BioNTech/Pfizer) Vaccine

“…1,2 Cardiac tamponade has been reported following mRNAbased COVID-19 vaccination and COVID-19 infection. [3][4][5][6][7][8][9][10] Globally, there have been approximately 596 million cases of COVID-19 and 6.4 million reported deaths as of July 2022. Over 12.6 billion vaccination doses have been provided over 184 countries, which averages to be 161 injections per 100 persons worldwide.…”