Cardiac sympathetic neurons are additional cells affected in genetically determined arrhythmogenic cardiomyopathy
Induja Perumal Vanaja,
Arianna Scalco,
Marco Ronfini
et al.
Abstract:Arrhythmogenic cardiomyopathy (AC) is a familial cardiac disease, mainly caused by mutations in desmosomal genes, which accounts for most cases of stress‐related arrhythmic sudden death, in young and athletes. AC hearts display fibro‐fatty lesions that generate the arrhythmic substrate and cause contractile dysfunction. A correlation between physical/emotional stresses and arrhythmias supports the involvement of sympathetic neurons (SNs) in the disease, but this has not been confirmed previously. Here, we comb… Show more
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