Cardiac sympathetic index identifies patients with Parkinson's disease and REM behavior disorder

Salsone, Maria; Vescio, Basilio; Fratto, Alessandra; Sturniolo, Miriam; Arabia, Gennarina; Gambardella, Antonio; Quattrone, Aldo

doi:10.1016/j.parkreldis.2016.03.004

Cited by 21 publications

(35 citation statements)

References 22 publications

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“…In our study, we used a combined approach including simultaneously PSG‐HRV analysis in order to investigate the cardiac autonomic system in patients with OSA at baseline (without CPAP therapy) and after a full‐night of acute CPAP therapy. We also calculated HRV‐derived measurements as the cardiac autonomic indexes as these two indexes have proven to be useful for accurately identifying patients with sleep disorders (Salsone et al., , ). Indeed, cardiac autonomic indexes obtained as the night‐to‐day ratio for parasympathetic and sympathetic activities can reflect the circadian cardiac autonomic fluctuations often occurring in patients with OSA and RBD (Salsone et al., , ).…”

Section: Discussionmentioning

confidence: 99%

“…We also calculated HRV‐derived measurements as the cardiac autonomic indexes as these two indexes have proven to be useful for accurately identifying patients with sleep disorders (Salsone et al., , ). Indeed, cardiac autonomic indexes obtained as the night‐to‐day ratio for parasympathetic and sympathetic activities can reflect the circadian cardiac autonomic fluctuations often occurring in patients with OSA and RBD (Salsone et al., , ). In a previous report (Salsone et al., ), we demonstrated that patients with OSA had a higher nocturnal parasympathetic activity than controls, and that CPI better than CSI differentiated patients with OSA from controls.…”

Section: Discussionmentioning

confidence: 99%

“…However, our cardiac autonomic indexes are measures derived from classical HRV parameters such as HF and LF spectral components acquired according to previously published HRV methodology (Vanderlei et al., ). Moreover, cardiac autonomic indexes so calculated have been demonstrated to be useful to identify patients with sleep disorders (Salsone et al., , ).…”

Section: Discussionmentioning

confidence: 99%

“…In particular, each epoch was processed by means of the Lomb–Scargle algorithm, which computes the power spectrum of unevenly sampled data. LF (sympathetic system) power was taken in the 0.04–0.15 Hz frequency band, while HF (parasympathetic system) power was taken in the 0.15–0.4 Hz band, as described in detail previously (Salsone et al., , ).…”

Section: Methodsmentioning

confidence: 99%

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Usefulness of cardiac parasympathetic index in CPAP‐treated patients with obstructive sleep apnea: A preliminary study

Salsone

Marelli

Vescio³

et al. 2019

Journal of Sleep Research

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Cardiac autonomic indexes, including cardiac parasympathetic index and cardiac sympathetic index, have been reported to accurately identify patients with sleep disorders such as obstructive sleep apnea. Our study aimed to assess cardiac autonomic indexes in patients with obstructive sleep apnea before and during a single full‐night continuous positive airway pressure therapy using a combined approach. Our simultaneous heart rate variability‐polysomnographic study included 16 never‐treated obstructive sleep apnea patients. Two patients dropped out. Patients underwent combined recordings in two consecutive days, at baseline and during a single full‐night of acute continuous positive airway pressure treatment. We calculated cardiac parasympathetic index and cardiac sympathetic index as night/day ratio for high‐frequency and low‐frequency heart rate variability spectral components, respectively. Continuous positive airway pressure treatment significantly reduced cardiac autonomic indexes values in comparison with baseline values (cardiac parasympathetic index: p < .0001; cardiac sympathetic index: p = .001). After acute continuous positive airway pressure treatment, the percentage of decrease of cardiac parasympathetic index was greater than that of cardiac sympathetic index (51.02 ± 15.72 versus 34.64 ± 26.93). A positive statistical correlation was also found between decrease of cardiac parasympathetic index and decrease of apnea–hypopnea index after continuous positive airway pressure (p < .001). This study improves the knowledge on cardiac autonomic modulation during acute continuous positive airway pressure therapy in obstructive sleep apnea. Our results demonstrate that both autonomic indexes decreased significantly after a single‐night of acute continuous positive airway pressure therapy. Cardiac parasympathetic index more than cardiac sympathetic index was related to decrease of apnea–hypopnea index after continuous positive airway pressure therapy, thus representing a potential help in everyday clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Usefulness of cardiac parasympathetic index in CPAP‐treated patients with obstructive sleep apnea: A preliminary study

Salsone

Marelli

Vescio³

et al. 2019

Journal of Sleep Research

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“…Recently, an investigation was conducted to evaluate whether the other non-symptoms such as RBD contribute to the cardiovascular dysautonomia. The results showed that both sympathetic and parasympathetic values are higher at night, implying that RBD might be susceptible to cardiovascular diseases, and that these two indices had a specificity of 100% for distinguishing RBD patients from those all PD individuals [60].…”

Section: Autonomic System Dysfunctionsmentioning

confidence: 96%

A New Perspective for Parkinson’s Disease: Circadian Rhythm

Wang

et al. 2016

Neurosci. Bull.

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Circadian rhythm is manifested by the behavioral and physiological changes from day to night, which is controlled by the pacemaker and its regulator. The former is located at the suprachiasmatic nuclei (SCN) in the anterior hypothalamus, while the latter is composed of clock genes present in all tissues. Circadian desynchronization influences normal patterns of day-night rhythms such as sleep and alertness cycles, rest and activity cycles. Parkinson's disease (PD) exhibits diurnal fluctuations. Circadian dysfunction has been observed in PD patients and animal models, which may result in negative consequences to the homeostasis and even exacerbate the disease progression. Therefore, circadian therapies, including light stimulation, physical activity, dietary and social schedules, may be helpful for PD patients. However, the cellular and molecular mechanisms that underlie the circadian dysfunction in PD remain elusive. Further research on circadian patterns is needed. This article summarizes the existing research on the circadian rhythms in PD, focusing on the clinical symptom variations, molecular changes, as well as the available treatment options.

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Heart rate variability in leucine‐rich repeat kinase 2‐associated Parkinson's disease

et al. 2017

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Cardiac sympathetic index identifies patients with Parkinson's disease and REM behavior disorder

Cited by 21 publications

References 22 publications

Usefulness of cardiac parasympathetic index in CPAP‐treated patients with obstructive sleep apnea: A preliminary study

Usefulness of cardiac parasympathetic index in CPAP‐treated patients with obstructive sleep apnea: A preliminary study

A New Perspective for Parkinson’s Disease: Circadian Rhythm

Heart rate variability in leucine‐rich repeat kinase 2‐associated Parkinson's disease

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