Cardiac sympathetic denervation and dementia in de novo Parkinson's disease: A 7-year follow-up study

Choi, Mihye; Yoon, Jung Han; Yong, Suk Woo

doi:10.1016/j.jns.2017.09.010

Cited by 12 publications

(10 citation statements)

References 37 publications

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“…The HMR, a quantification parameter of cardiac I-MIBG uptake, is known to reflect receptor density and to show the integrity of presynaptic nerve terminals [18]. A reduction of the HMR has also been reported to be related to dementia development, disease progression, motor severity, or clinical phenotypes in patients with PD [8,[19][20][21][22].…”

Section: Resultsmentioning

confidence: 99%

Relationship between the washout rate of I-123 MIBG scans and autonomic function in Parkinson’s disease

Jeong

Cheon

et al. 2020

PLoS ONE

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Section: Resultsmentioning

confidence: 99%

Relationship between the washout rate of I-123 MIBG scans and autonomic function in Parkinson’s disease

Jeong

Cheon

et al. 2020

PLoS ONE

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“…Several cross-sectional studies have shown a correlation between low MIBG uptake and various non-motor symptoms of PD, including hyposmia, RBD, cognitive deficits, and visual hallucinations 39–42 . Recent longitudinal studies of patients with PD showed that MIBG uptake declined chronologically, and severely reduced MIBG uptake at baseline was correlated with the faster progression of motor dysfunction and increased likelihood of developing dementia 43,44 . On the basis of these observations, low MIBG uptake is considered to be related to the wider extension of neurodegeneration with Lewy body pathology.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid

Kakuda

Ikenaka

Araki

et al. 2019

Sci Rep

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α-Synuclein aggregates, a key hallmark of the pathogenesis of Parkinson’s disease, can be amplified by using their seeding activity, and the evaluation of the seeding activity of cerebrospinal fluid (CSF) is reportedly useful for diagnosis. However, conventional shaking-based assays are time-consuming procedures, and the clinical significance of the diversity of seeding activity among patients remains to be clarified. Previously, we reported a high-throughput ultrasonication-induced amyloid fibrillation assay. Here, we adapted this assay to amplify and detect α-synuclein aggregates from CSF, and investigated the correlation between seeding activity and clinical indicators. We confirmed that this assay could detect α-synuclein aggregates prepared in vitro and also aggregates released from cultured cells. The seeding activity of CSF correlated with the levels of α-synuclein oligomers measured by an enzyme-linked immunosorbent assay. Moreover, the seeding activity of CSF from patients with Parkinson’s disease was higher than that of control patients. Notably, the lag time of patients with Parkinson’s disease was significantly correlated with the MIBG heart-to-mediastinum ratio. These findings showed that our ultrasonication-based assay can rapidly amplify misfolded α-synuclein and can evaluate the seeding activity of CSF.

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“…Impaired cardiac sympathetic innervation, which is associated with a muted cardiac response following a hypotensive stimulus,56 has also been linked to cognitive dysfunction in α-synucleinopathies. In a study of 93 de novo PD patients, postganglionic adrenergic denervation was assessed by cardiac iodine-123-meta-iodobenzylguanidine uptake 57. Low uptake at baseline was associated with a 3.5-fold increased risk of incident dementia over a mean 6.7-year follow-up period 57.…”

Section: Oh and Incident Cognitive Declinementioning

confidence: 99%

<p>Orthostatic hypotension and dementia incidence: links and implications</p>

Robertson¹,

Udow²,

Espay³

et al. 2019

NDT

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Orthostatic hypotension (OH) is a common condition, particularly in patients with α-synucleinopathies such as Parkinson’s disease, and has a significant impact on activities of daily living and quality of life. Recent data suggest an association with cognitive impairment. Herein, we review the evidence that OH increases the odds of incident mild cognitive impairment and dementia. Potential mechanisms underlying the putative relationship are discussed, including cerebral hypoperfusion, supine hypertension, white matter hyperintensities, and neurodegeneration. Finally, we highlight the challenges with respect to treatment and the negative impact on the quality of life and long-term prognosis presented by the coexistence of OH and dementia. Large population-based studies have reported that OH is associated with about a 20% increased risk of dementia in the general population, while smaller cohort studies suggest an even greater effect in patients with α-synucleinopathies (3- to 7-fold higher than controls). Ultimately, OH exposure is difficult to quantify, predominantly limited to pressure regulation during a one-time orthostatic challenge, and the causative association with dementia may turn out to be bidirectional, especially in α-synucleinopathies. Early diagnosis and treatment of OH may improve long-term prognosis.

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Cardiac sympathetic denervation and dementia in de novo Parkinson's disease: A 7-year follow-up study

Cited by 12 publications

References 37 publications

Relationship between the washout rate of I-123 MIBG scans and autonomic function in Parkinson’s disease

Relationship between the washout rate of I-123 MIBG scans and autonomic function in Parkinson’s disease

Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid

<p>Orthostatic hypotension and dementia incidence: links and implications</p>

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