Cardiac structure growth pattern determined by echocardiography.

Roge, C.; Silverman, Norman H.; Hart, Patricia; Ray, Rinki

doi:10.1161/01.cir.57.2.285

Cited by 140 publications

(65 citation statements)

References 12 publications

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“…M-mode echocardiography is used most widely to measure left ventricular mass because of its wide availability, moderate expense, anatomic and prognostic validation (Rogé et al, 1978;Devereux et al). As, increased LVM has been established as a strong independent risk factor for cardiovascular morbidity (eg., arrhythmia, congestive heart failure, and myocardial infarction) and mortality, for management of the treatment and evaluation of the prognosis, the normal values of LVM are also needed (Levy et al, 1987;Epstein et al, 1975).…”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Mass in Normal Children and its Correlation with Weight, Height and Body Surface Area

Kervancıoğlu

Tuncer

et al. 2011

Int. J. Morphol.

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SUMMARY:Echocardiographic measurement of left ventricular mass (LVM) is being used for the diagnosis of left ventricular hypertrophy in children with various cardiovascular diseases. The purposes of this study was to establish normal values of LVM according to weight, height and body surface area (BSA) in children and to determine the sex differences. We evaluated 208 children (143 males and 65 females), aged 1 day to 14 years who had no cardiovascular disease. The end-diastolic left ventricular internal dimension (LVIDd), end-diastolic left ventricular posterior wall thickness (LVPWd) and end-diastolic interventricular septum (IVSd) values were determined by M-mode echocardiographic examination. By using these values, left ventricular mass was calculated. The difference between LVIDd, LVPWd and LVM values of boys and girls were not statistically significant . We observed statistically significant differences between the sexes relative to IVSd and LVM/BSA values. The left ventricular mass and its components presented a good correlation with age, weight, height and BSA. The study let us know the lower and upper limits of cardiac dimensions and LVM obtained by echocardiography in normal Turkish children according to BSA. Also, as the LVM/BSA values show gender difference in children, sex should be taken in consideration while evaluating the left ventricular hypertrophy.

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Section: Discussionmentioning

confidence: 99%

Left Ventricular Mass in Normal Children and its Correlation with Weight, Height and Body Surface Area

Kervancıoğlu

Tuncer

et al. 2011

Int. J. Morphol.

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“…The study included detailed M-mode measurements, two-dimensional echocardiography, and color Doppler interrogation. Left ventricular hypertrophy (LVH) was defined as left ventricular septum or posterior wall thickness that was greater than the 90th percentile for body surface area (10). All patients were subsequently followed on a regular basis by the pediatric cardiology team.…”

Section: Methodsmentioning

confidence: 99%

The Heart of Children with Steroid-Resistant Nephrotic Syndrome

Frishberg

Feinstein²,

Rinat³

et al. 2006

Journal of the American Society of Nephrology

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Mutations in the gene NPHS2 encoding podocin are responsible for a recessive form of steroid-resistant nephrotic syndrome (SRNS). The common phenotype is of massive proteinuria in early childhood that tends to progress to end-stage renal failure. Extrarenal manifestations have not been described. Twenty-two children with SRNS from six unrelated Arab families were found to be homozygous for the R138X mutation in NPHS2. Eighteen patients underwent cardiac evaluation at diagnosis of SRNS while they had normal BP and preserved renal function. Cardiac anomalies were detected in 16 (89%) children: Left ventricular hypertrophy in eight, pulmonary stenosis in six, discrete subaortic stenosis in two, and Ebstein anomaly and ventricular septal defect in one each. The remaining four affected individuals were assessed only once they had end-stage renal failure. They had severe left ventricular hypertrophy and experienced repeated episodes of heart failure. Two control groups were equally evaluated. The first consisted of 37 siblings without nephrotic syndrome, of whom only one carrier had a cardiac defect (P < 0.001). None of the second group, which included 22 children with persistent nephrotic syndrome as a result of other causes, had a cardiac anomaly (P < 0.001). Cardiac disorders in homozygotes for mutations in NPHS2 cannot be attributed to an association by chance or to a state of persistent nephrotic syndrome. Because human podocin mRNA is expressed in fetal heart, it is speculated that it may have a role in normal cardiac development. Cardiac evaluation is recommended at the time of diagnosis of SRNS due to mutations in podocin.

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“…These results were in agreement with our data. The similar relationships of left ventricular diameters and left ventricular posterior wall thickness in diastole with body surface area were shown by Epstein et al (1975) and Roge et al (1978), but no regression equations between them were presented in these reports. The left ventricular shortening fraction was reported to be 36% by Gutgesel and Paquet (1978) and by Henry et al (1978), and it was slightly lower than that in the present study.…”

Section: Discussionmentioning

confidence: 63%

“…Although several reports have been published concerning normal values for it, these results varied among investigators (Lundstrom 1974;Goldberg et al 1975; Received May 25, 1985; accepted for publication April 14, 1986. 31 Epstein et al 1975;Gutgesel and Paquet 1978;Henry et al 1978;Roge et al 1978). The purpose of this paper is to establish the relationship between normal value for echocardiographic parameters showing left ventricular performance and body surface area in infants and children.…”

mentioning

confidence: 99%