Cardiac Structure–Function MRI in Patients After Heart Transplantation

Dolan, Ryan S.; Rahsepar, Amir Ali; Blaisdell, Julie; Lin, Kai; Suwa, Kenichiro; Ghafourian, Kambiz; Wilcox, Jane E.; Khan, Sadiya S.; Vorovich, Esther; Rich, Jonathan D.; Anderson, Allen S.; Yancy, Clyde W.; Collins, Jeremy D.; Markl, Michael; Carr, James C.

doi:10.1002/jmri.26275

Cited by 15 publications

(13 citation statements)

References 34 publications

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“…1. The number of studies per population was described as total studies (number of studies reporting T 2 data & number of studies reporting T 2 * data): A total of 31 (22 T 2 & 13 T 2 * ) studies were included in the myocardial infarction (MI) population [26,, 11 (11 T 2 & 0 T 2 * ) in heart transplantation [27,[69][70][71][72][73][74][75][76][77][78] [188] ( Table 1). The absolute T 2 and T 2 * values are dependent on field strength [189,190], therefore the average mapping values were noted separately for 1.5 T and 3 T, and it was also used as covariate in the meta-regression analysis.…”

Section: Literature Searchmentioning

confidence: 99%

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Cardiovascular magnetic resonance native T2 and T2* quantitative values for cardiomyopathies and heart transplantations: a systematic review and meta-analysis

Snel

Boomen

Hernández

et al. 2020

Journal of Cardiovascular Magnetic Resonance

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Background: The clinical application of cardiovascular magnetic resonance (CMR) T 2 and T 2 * mapping is currently limited as ranges for healthy and cardiac diseases are poorly defined. In this meta-analysis we aimed to determine the weighted mean of T 2 and T 2 * mapping values in patients with myocardial infarction (MI), heart transplantation, non-ischemic cardiomyopathies (NICM) and hypertension, and the standardized mean difference (SMD) of each population with healthy controls. Additionally, the variation of mapping outcomes between studies was investigated. Methods: The PRISMA guidelines were followed after literature searches on PubMed and Embase. Studies reporting CMR T 2 or T 2 * values measured in patients were included. The SMD was calculated using a random effects model and a meta-regression analysis was performed for populations with sufficient published data. Results: One hundred fifty-four studies, including 13,804 patient and 4392 control measurements, were included. T 2 values were higher in patients with MI, heart transplantation, sarcoidosis, systemic lupus erythematosus, amyloidosis, hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) and myocarditis (

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Section: Literature Searchmentioning

confidence: 99%

“…The weighted mean T 2 values at 1.5 T in heart transplant patients was 54.6 ± 5.2 ms and 49.2 ± 2.5 ms in controls [27,[69][70][71][72][73][74][75][76][77][78] (Table 1, Fig. 5).…”

Section: Heart Transplantmentioning

confidence: 99%

Cardiovascular magnetic resonance native T2 and T2* quantitative values for cardiomyopathies and heart transplantations: a systematic review and meta-analysis

Snel

Boomen

Hernández

et al. 2020

Journal of Cardiovascular Magnetic Resonance

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“…25,37,38 Markl et al found reduced LV diastolic long-axis and radial velocities 25 while Dolan et al found reduced LV systolic long-axis velocities and increased diastolic LV radial velocities in Htx patients. 38 We found both reduced systolic and diastolic LV and RV long-axis velocities in the pediatric Htx recipients. There were minimal differences in radial velocities in our pediatric cohort.…”

Section: Discussionmentioning

confidence: 98%

“…Comparing TPM in Htx patients to controls has yielded mixed results . Markl et al found reduced LV diastolic long‐axis and radial velocities while Dolan et al found reduced LV systolic long‐axis velocities and increased diastolic LV radial velocities in Htx patients . We found both reduced systolic and diastolic LV and RV long‐axis velocities in the pediatric Htx recipients.…”

Section: Discussionmentioning

confidence: 99%

Myocardial velocity, intra‐, and interventricular dyssynchrony evaluated by tissue phase mapping in pediatric heart transplant recipients

Berhane

Ruh

Husain

et al. 2019

Magnetic Resonance Imaging

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Background Endomyocardial biopsy (EMB) is the standard method for detecting allograft rejection in pediatric heart transplants (Htx). As EMB is invasive and carries a risk of complications, there is a need for a noninvasive alternative for allograft monitoring. Purpose To quantify left and right ventricular (LV & RV) peak velocities, velocity twist, and intra‐/interventricular dyssynchrony using tissue phase mapping (TPM) in pediatric Htx compared with controls, and to explore the relationship between global cardiac function parameters and the number of rejection episodes to these velocities and intra‐/interventricular dyssynchrony. Study Type Prospective. Subjects Twenty Htx patients (age: 16.0 ± 3.1 years, 11 males) and 18 age‐ and sex‐matched controls (age: 15.5 ± 4.3 years, nine males). Field Strength/Sequence 5T; 2D balanced cine steady‐state free‐precession (bSSFP), TPM (2D cine phase contrast with three‐directional velocity encoding). Assessment LV and RV circumferential, radial, and long‐axis velocity–time curves, global and segmental peak velocities were measured using TPM. Short‐axis bSSFP images were used to measure global LV and RV function parameters. Statistical Tests A normality test (Lilliefors test) was performed on all data. For comparisons, a t‐test was used for normally distributed data or a Wilcoxon rank‐sum test otherwise. Correlations were determined by a Pearson correlation. Results Htx patients had significantly reduced LV (P < 0.05–0.001) and RV (P < 0.05–0.001) systolic and diastolic global and segmental long‐axis velocities, reduced RV diastolic peak twist (P < 0.01), and presented with higher interventricular dyssynchrony for long‐axis and circumferential motions (P < 0.05–0.001). LV diastolic long‐axis dyssynchrony (r = 0.48, P = 0.03) and RV diastolic peak twist (r = –0.64, P = 0.004) significantly correlated with the total number of rejection episodes. Data Conclusion TPM detected differences in biventricular myocardial velocities in pediatric Htx patients compared with controls and indicated a relationship between Htx myocardial velocities and rejection history. Level of Evidence: 2 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2020;51:1212–1222.

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“…In this context, 2D cine phase contrast MRI with three-directional velocity encoding, termed tissue phase mapping (TPM), is a well-established technique to quantify LV regional myocardial velocities (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41) but has rarely been applied to the RV. In 2000, Kayser et al (6) analyzed RV wall motion with TPM for the first time, and more recently biventricular function in healthy adults (42) and adult patients with pulmonary hypertension (43) have been investigated.…”

Section: Introductionmentioning

confidence: 99%

Impact of age and cardiac disease on regional left and right ventricular myocardial motion in healthy controls and patients with repaired tetralogy of fallot

Ruh

Sarnari

Berhane

et al. 2019

Int J Cardiovasc Imaging

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Purpose-The assessment of both left (LV) and right ventricular (RV) motion is important to understand the impact of heart disease on cardiac function. The MRI technique of tissue phase mapping (TPM) allows for the quantification of regional biventricular three-directional myocardial velocities. The goal of this study was to establish normal LV and RV velocity parameters across a wide range of pediatric to adult ages and to investigate the feasibility of TPM for detecting impaired regional biventricular function in patients with repaired tetralogy of Fallot (TOF). Methods-36 healthy controls (age=1-75 years) and 12 TOF patients (age=5-23 years) underwent cardiac MRI including TPM in short-axis locations (base, mid, apex). For ten adults, a second TPM scan was used to assess test-retest reproducibility. Data analysis included the calculation of biventricular radial, circumferential, and long-axis velocity components, quantification of systolic and diastolic peak velocities in an extended 16+10 LV+RV segment model, and assessment of inter-ventricular dyssynchrony.

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Cardiac Structure–Function MRI in Patients After Heart Transplantation

Abstract: 2 Technical Efficacy Stage: 2 J. MAGN. RESON. IMAGING 2018.

Cited by 15 publications

References 34 publications

Cardiovascular magnetic resonance native T2 and T2* quantitative values for cardiomyopathies and heart transplantations: a systematic review and meta-analysis

Cardiovascular magnetic resonance native T2 and T2* quantitative values for cardiomyopathies and heart transplantations: a systematic review and meta-analysis

Myocardial velocity, intra‐, and interventricular dyssynchrony evaluated by tissue phase mapping in pediatric heart transplant recipients

Impact of age and cardiac disease on regional left and right ventricular myocardial motion in healthy controls and patients with repaired tetralogy of fallot

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