Cardiac Stem Cell Therapy, Resident Progenitor Cells and the role of Cellular Signalling; a Review

Abstract

Cardiovascular disease (CVD) remains the most common cause of death worldwide. Unhealthy lifestyle choices promote an upward trend of primary risk factors for CVD. As a result, novel methods of treatment are required. The myocardium itself could serve as a source of treatment, via resident cardiac progenitor cells (CPC). A brief overview of current studies and findings related to the potential of differentiation of CPCs to form mature cardiomyocytes (CM) and thereby heal damaged myocardial tissue, as well as implications of these findings for further research areas and possible treatments, is offered. Also investigated is the possible role of CM cell reprogramming, cardiac fibroblasts and signalling molecules in treatment of CVD. Running title: Cardiac stem cells -review

Transcriptomic Profile of Genes Regulating the Structural Organization of Porcine Atrial Cardiomyocytes during Primary In Vitro Culture

“…It is necessary to understand the mechanisms regulating cardiac muscle cells that may enable application in cell-based therapy. The myocardium could serve as a source of cells that could be expanded as a treatment platform [ 5 , 24 ]. Therefore, the detailed characterization of cells obtained from the myocardium is important.…”

Expression Profile of Genes Encoding Proteins Involved in Regulation of Vasculature Development and Heart Muscle Morphogenesis—A Transcriptomic Approach Based on a Porcine Model

“…Given these factors, the whole complex process of neovascularization [14] taking place within the heart tissue is so crucial to understanding. Moreover, because the myocardium itself could serve as a source of treatment, via resident cardiac progenitor cells [15] therefore generation of new blood vessels for delivery oxygen and nutrients to newly created cells is necessary for proper cardiac function. Regardless of the source of the cells involved in the development of new coronary vessels, regulation at the molecular level is a key aspect for the effectiveness of vascularization.…”