Cardiac stem cell niches

Leri, Annarosa; Rota, Marcello; Hosoda, Toru; Goichberg, Polina; Anversa, Piero

doi:10.1016/j.scr.2014.09.001

Cited by 72 publications

(57 citation statements)

References 100 publications

(139 reference statements)

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“…Satellite cells of the skeletal muscle are located along muscle fibers, between the basement membrane and the sarcolemma [28]. Whereas cardiac progenitors have been identified in the heart, the specific niche localization remains elusive [53]. However, it has been reported that the myocardium possesses interstitial structures with the architectural organization of stem cell niches that harbor cardiac progenitors [54].…”

Section: Diversity Of the Stem Cell Nichementioning

confidence: 99%

Unhealthy Stem Cells: When Health Conditions Upset Stem Cell Properties

Pérez

Lucas

Gálvez

2018

Cell Physiol Biochem

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The stem cell field has grown very rapidly during the last decade, offering the promise of innovative therapies to treat disease. Different stem cell populations have been isolated from various human adult tissues, mainly from bone marrow and adipose tissue, but many other body tissues harbor a stem cell population. Adult tissue stem cells are invariably found in discrete microenvironments termed niches, where they play key roles in tissue homeostasis by enabling lifelong optimization of organ form and function. Some diseases are known to strike at the stem cell population, through alterations in their specific microenvironments, making them non-viable. Furthermore, it has been shown that a transformed stem cell population could prompt the development of certain cancers. This review focuses on the potential negative aspects of a range of diseases on the activity of stem cells and how their potential use in cell therapies may be affected.

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Section: Diversity Of the Stem Cell Nichementioning

confidence: 99%

Unhealthy Stem Cells: When Health Conditions Upset Stem Cell Properties

Pérez

Lucas

Gálvez

2018

Cell Physiol Biochem

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“…However, cardiac niches are not limited to the subepicardium and are dispersed throughout the myocardium (328). CPC niches are more numerous in the atria and apex, which represent protected anatomical areas characterized by low hemodynamic stress (44,117,120,141,198,280,327,328). The process of myocyte formation lacks directionality; the scattered distribution of the sites of cardiomyogenesis complicates the demonstration of the topography of cardiac niches.…”

Section: Cpc Nichesmentioning

confidence: 99%

Aging Effects on Cardiac Progenitor Cell Physiology

Rota

Goichberg

Anversa

et al. 2015

Comprehensive Physiology

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Cardiac aging has been confounded by the concept that the heart is a postmitotic organ characterized by a predetermined number of myocytes, which is established at birth and largely preserved throughout life until death of the organ and organism. Based on this premise, the age of cardiac cells should coincide with that of the organism; at any given time, the heart would be composed of a homogeneous population of myocytes of identical age. The discovery that stem cells reside in the heart and generate cardiac cell lineages has imposed a reconsideration of the mechanisms implicated in the manifestations of the aging myopathy. The progressive alterations of terminally differentiated myocytes, and vascular smooth muscle cells and endothelial cells may represent an epiphenomenon dictated by aging effects on cardiac progenitor cells (CPCs). Changes in the properties of CPCs with time may involve loss of self-renewing capacity, increased symmetric division with formation of daughter committed cells, partial depletion of the primitive pool, biased differentiation to the fibroblast fate, impaired ability to migrate, and forced entry into an irreversible quiescent state. Telomere shortening is a major variable of cellular senescence and organ aging, and support the notion that CPCs with critically shortened or dysfunctional telomeres contribute to myocardial aging and chronic heart failure. These defects constitute the critical variables that define the aging myopathy in humans. Importantly, a compartment of functionally competent human CPCs persists in the decompensated heart pointing to stem cell therapy as a novel form of treatment for the aging myopathy.

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“…Until the research of Anversa and Nadal-Ginard (Anversa and Nadal-Ginard, 2002) was published, it was thought that cardiomyocytes in adults do not have the ability to divide. Later studies have shown that regeneration of the cardiac muscle is more intense in ischemic heart failure (Urbanek et al, 2005, Doppler et al, 2013, and that cardiac stem cells (CSC) which are able to differentiate into all structural components of the heart exist (Barile et al, 2007Leri et al, 2014.…”

Section: Heart -Biological Backgroundmentioning

confidence: 99%