Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle

Aydın, Suna; Kuloğlu, Tuncay; Eren, Mehmet Nesimi; Çelik, Ahmet; Yılmaz, Musa; Kalaycı, Mehmet; Şahin, İ̇brahim; Güngör, Orhan; Gürel, Ali; Ögetürk, Murat; Dabak, Özlem Dürrin

doi:10.1016/j.peptides.2013.11.024

Cited by 138 publications

(112 citation statements)

References 19 publications

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“…FNDC5 mRNA/irisin is produced not only in skeletal muscles of humans and animals, but also in other tissues including the liver, though to a limited extent (32)(33)(34)(35), which is involved in energy homeostasis and the metabolism of the body; hence, a connector of the skeletal muscle and the other tissues (32,36). Particularly with respect to the liver, it appears that irisin is produced by the liver cells, Kupfer cells and endothelial sinusoids (34,35). The function of the liver-derived irisin is not yet known.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

Rashidlamir

Hoseinzadeh

Dashtkhaki

2017

Ann. Appl. Sport Sci

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Background. The accumulation of excess triglyceride in the liver and a decrease in brown adipose tissue is related to the fatty liver disease. Regular physical activity can take part in regulating fat oxidation and inhibiting fat accumulation by creating and releasing some myokines. Nevertheless, the effectiveness of each training method in this regard is still not certain. Objective(s). This study aims at comparing the effects of resistance and endurance training on FNDC5 (the precursor of irisin myokine) gene expression in male rat liver tissues.. Methods. Fifteen Wistar male rats (aged 10-12 weeks with an average weight of 331.8 ±63.09 gr) were used. After being taken to the animals' laboratory, the subjects were randomly assigned to three equal groups viz: control (N=5), endurance (N=5) and resistance (N=5). For the purpose of tissue sampling, all these subjects were anesthetized 72 hours after the experiment had been completed. The liver tissue was immediately removed and then quickly frozen in liquid nitrogen and kept at a temperature of -80o C until RNA extraction. FNDC5 relative gene expression was identified by Real-time PCR method. Results. Data analysis revealed a significant difference in FNDC5 gene expression among the groups (P=0.008, Chi Square=31.791). No significant difference was observed between the resistance training and endurance training groups in FNDC5 gene expression, though (P=0.959). Conclusion. It can be established that both resistance and endurance training can similarly affect the production and secretion of exerciseinduced myokines, including FNDC5 irisin, which can in turn protect against obesity and its impacts on the liver tissue by stimulating the process of browning of white fat.

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Section: Discussionmentioning

confidence: 99%

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

Rashidlamir

Hoseinzadeh

Dashtkhaki

2017

Ann. Appl. Sport Sci

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“…It shows its effect in autocrine and paracrine manner similarly to other locally synthesized hormones (14). Another current review has underlined that irisin and similar hormones with local effects function without losing their contact with central endocrine organs (e.g., pancreas, thyroid) (8).…”

Section: Discussionmentioning

confidence: 87%

Circulating levels of irisin is elevated in hypothyroidism, a case-control study

Ateş

Altay

Topçuoğlu

et al. 2016

Arch. Endocrinol. Metab.

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Objective: Our objective in this study was to determine the relationship between irisin hormone, which has a similar effect with thyroid hormones on adipose tissue and the metabolism, and the thyroid functions and the obesity secondary to thyroid disease. Subjects and methods: Seventy--four patients were included in the study, of the patients, 37 were newly diagnosed with Hashimoto's thyroiditis related hypothyroidism but not started on a treatment yet, and the remaining 37 were healthy volunteers without a known disease. Serum thyroid stimulating hormone (TSH), free thyroxin (fT4), anti-thyroglobulin and anti-thyroid peroxidase were measured and thyroid ultrasonography was performed in both groups. Serum irisin levels were measured using the commercially available ELISA kit. Results: The hypothyroidism group had higher levels of irisin compared to the control group (2.77 ng/mL vs. 2.15 ng/mL respectively; p = 0.017). The hypothyroidism group had higher median levels of irisin in the obese patients than those in the control group (3.10 ng/mL vs. 2.10 ng/mL respectively; p = 0.013). Irisin level was negatively correlated with age in the whole population and patients with hypothyroidism (r = -0.255, p = 0.028; r = -0.346, p = 0.036 respectively). Irisin level was positively correlated with TSH (r = 0.247, p = 0.034) but negatively correlated with the fT4 (r = -0.316, p = 0.006) in the whole population. Obesity, fT4 and irisin levels were identified to be independent predictors in the diagnosis of hypothyroidism in the multivariable logistic regression analysis. Conclusion: To the best of our knowledge, this study is the first in literature to identify that obesity, irisin level and fT4 level are independent risk factors for hypothyroidism. Arch Endocrinol Metab. 2016;60(2):95-100

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“…Irisin is secreted by muscle tissue during exercising [12] and shows wide spread in body tissues [14]. It has been shown that irisin exists not only in muscles but also in white fat tissue, liver, adult and fetal testes as well as in epididymis tissue [13,34,35]. In a study conducted by Bostrom et al, the rats were injected adenovirus particles that makes the secretion of FNDC5 possible, and it was observed that the irisin level increased 3-4 folds, and brown fat cell development accompanied with the decrease in white fat tissue [12].…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that the gene expression of the FNDC5 is widespread in different body tissues mainly in muscles, white fat tissue, testes, epididymis, rectum, intracranial artery and pericardium [13,14]. In addition, the irisin has been shown in skeleton muscle, subcutaneous adipose tissue, heart muscle, brain-spinal cord fluid, human breast milk, saliva and purkinje cells in the cerebellum and in testicle tissue [15][16][17]. The most important roles of this peptide are increasing the uncoupling protein-1 (UCP1) levels, converting the white fat tissue cells into brown fat tissue cells and decreasing the obesity [12].…”

Section: Introductionmentioning

confidence: 99%

Is Irisin an Anticarcinogenic Peptide?

Tekin¹,

Erden²,

Sandal

et al. 2015

Med-Science

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Irisin is thought an anti obesity hormone PC3). Effects of irisin were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. At the end of study, all concentrations of irisin reduced viability in the three types of prostate cells, but only 10 and 100 nM concentrations of the irisin caused a significant decreases (p<0.05). Consequently, high concentrations of irisin in both androgen

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Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle

Cited by 138 publications

References 19 publications

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

Circulating levels of irisin is elevated in hypothyroidism, a case-control study

Is Irisin an Anticarcinogenic Peptide?

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