Cardiac side effects of psychiatric drugs

Mackin, Paul

doi:10.1002/hup.915

Cited by 139 publications

(132 citation statements)

References 58 publications

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“…[204][205][206][207] Myocarditis and cardiomyopathy are rare but potentially fatal complications of antipsychotic therapy. Both disorders have been demonstrated with clozapine.…”

Section: Antipsychotic Medicationsmentioning

confidence: 99%

Drugs That May Cause or Exacerbate Heart Failure

Page¹,

O’Bryant²,

Cheng³

et al. 2016

Circulation

345

185

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Heart failure is a common, costly, and debilitating syndrome that is associated with a highly complex drug regimen, a large number of comorbidities, and a large and often disparate number of healthcare providers. All of these factors conspire to increase the risk of heart failure exacerbation by direct myocardial toxicity, drug-drug interactions, or both. This scientific statement is designed to serve as a comprehensive and accessible source of drugs that may cause or exacerbate heart failure to assist healthcare providers in improving the quality of care for these patients.

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“…[204][205][206][207] Myocarditis and cardiomyopathy are rare but potentially fatal complications of antipsychotic therapy. Both disorders have been demonstrated with clozapine.…”

Section: Antipsychotic Medicationsmentioning

confidence: 99%

Drugs That May Cause or Exacerbate Heart Failure

Page¹,

O’Bryant²,

Cheng³

et al. 2016

Circulation

345

185

View full text Add to dashboard Cite

show abstract

“…The side-effects of thioridazine, as for all phenothiazines, are dose-dependent and include QTc prolongation, thereby increasing the risk of torsade de pointes with subsequent risk of sudden death [64]. To avoid the risk of sudden death in patients whose QTc interval is significantly increased, patients should be screened by ECG before and during treatment with thioridazine [63].…”

Section: Clinical Studiesmentioning

confidence: 99%

Potential antimicrobial agents for the treatment of multidrug-resistant tuberculosis

Alsaad

Wilffert

Altena

et al. 2013

European Respiratory Journal

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Treatment of multidrug-resistant (MDR) tuberculosis (TB) is challenging because of the high toxicity of second-line drugs and the longer treatment duration than for drug-susceptible TB patients. In order to speed up novel treatment for MDR-TB, we suggest considering expanding the indications of already available drugs. Six drugs with antimicrobial activity (phenothiazine, metronidazole, doxycycline, disulfiram, tigecycline and co-trimoxazole) are not listed in the World Health Organization guidelines on MDR-TB treatment but could be potential candidates for evaluation against Mycobacterium tuberculosis.A systematic review was conducted to evaluate antituberculous activity of these drugs against M. tuberculosis. We searched PubMed, Google Scholar and Embase for English articles published up to December 31, 2012.We reviewed in vitro, in vivo and clinical antituberculous activity of these drugs in addition to pharmacokinetics and side-effects. Of the drugs effective against actively replicating M. tuberculosis, cotrimoxazole seems to be the most promising, because of its consistent pharmacokinetic profile, easy penetration into tissue and safety profile. For the dormant state of TB, thioridazine may play a potential role as an adjuvant for treatment of MDR-TB. A strategy consisting of pharmacokinetic/pharmacodynamic studies, dose finding and phase III studies is needed to explore the role of these drugs in MDR-TB treatment.@ERSpublications Six antimicrobial drugs are not listed in WHO guidelines on MDR-TB treatment but could offer potential for TB treatment

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“…A cardiologist should remember some of the important cardiac factors in the safer selection of psychotropic drugs for the vulnerable patient in their daily clinical practice (O'Brien and Oyebode, 2003). Finally, a cardiologist should remember both positive and negative therapeutic benefits of psychotropic medicines in the cardiovascular system and follow the standard guidance for the practical management of psychotropic symptom in CVD patients (Mackin, 2008). To our knowledge, the findings of our present study are novel in many respects.…”

Section: Discussionmentioning

confidence: 75%

Evaluation of prescription pattern of psycholeptic medications at hospital discharge for patients with cardiovascular diseases in national cardiovascular disease hospital of Bangladesh

2017

J App Pharma Sci

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Background:The association of mental disorder with cardiac disease is not a coincidence rather a strong relationship exists in between those two. Objective: We investigated the prescription pattern of psycholeptic drugs during the discharge of patients in a national cardiovascular hospital. Methods: Data was collected from the National Institute of Cardiovascular Diseases (NICVD) at Dhaka in Bangladesh. In total, 1076 prescriptions were collected randomly from July 2012 to June 2013. Data were analyzed by using the software Statistical Package for Social Science (SPSS, version 22). Results: Benzodiazepine was the highest (99.3%) prescribed psycholeptic class while Bromazepam (87.49%) the highest advised molecule. Psycholeptics were advised for 15 (38.77%), 10 (19.91%), 30 (15.72%) and 7 (13.39%) days. The patient group without psycholeptic medication (M=6.64 day) spent significantly (p<0.05) a longer duration in the hospital compared to the psycholeptic medication (Mean=5.06 day) group. Age is significantly (p<0.05) associated with the duration of staying in hospital and polymorbidity. Also, polymorbidity (p<0.05) is significantly associated with the polypharmacy. No significant (p<0.05) correlation has been found between age and polypharmacy. Duration of psycholeptics intake was not significantly (p<0.05) related to either age, or polymorbidity,or length hospital stay. Conclusion: This study revealed that bromazepam is the utmost prescribed drug of choice at NICVD, Bangladesh. Frequent prescription of bromazepam indicates that this kind of patients' needs enough sleep to reduce their mental stress.

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Cardiac side effects of psychiatric drugs

Cited by 139 publications

References 58 publications

Drugs That May Cause or Exacerbate Heart Failure

Drugs That May Cause or Exacerbate Heart Failure

Potential antimicrobial agents for the treatment of multidrug-resistant tuberculosis

Evaluation of prescription pattern of psycholeptic medications at hospital discharge for patients with cardiovascular diseases in national cardiovascular disease hospital of Bangladesh

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