Cardiac side-effects of cancer chemotherapy

Monsuez, Jean‐Jacques; Charniot, J.-C.; Vignat, Noëlle; Artigou, Jean-Yves

doi:10.1016/j.ijcard.2010.03.003

Cited by 390 publications

(253 citation statements)

References 116 publications

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“…However, chemotherapy can also affect normal cells that rapidly divide and grow, such as those in the bone marrow, digestive tract, skin, hair and reproductive organs. When normal cells are damaged, this can cause side effects (Monsuez et al, 2010). In the last several years, traditional methods used to fight cancer cells have been largely based on the use of plant natural products.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of Trichoderma spp. Cultural Filtrate Against Human Cervical and Breast Cancer Cell Lines

El‐Rahman

El-Shafei²,

Иванова³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Trichoderma spp. are known as a rich source of secondary metabolites with biological activity belonging to a variety of classes of chemical compounds. These fungi also are well known for their ability to produce a wide range of antibiotic substances and to parasitize other fungi. In search for new substances, which might act as anticancer agents, the overall objective of this study was to investigate the cytotoxic effects of Trichoderma harzianum and Trichoderma asperellum cultural filtrates against human cervical and breast cancer cell lines (HeLa and MCF-7 cells respectively). To achieve this objective, cells were exposed to 20, 40, 60, 80 and 100 mg/ ml of both T. harzianum cultural filtrate (ThCF) and T. asperellum cultural filtrate (TaCF) for 24h, then the cell viability and the cytotoxic responses were assessed by using trypan blue and 3-

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Section: Introductionmentioning

confidence: 99%

Cytotoxicity of Trichoderma spp. Cultural Filtrate Against Human Cervical and Breast Cancer Cell Lines

El‐Rahman

El-Shafei²,

Иванова³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Furthermore, it is known that chemotherapy and radiotherapy contribute to the development and/or acceleration of the pathophysiology of cardiovascular disease. [7][8][9][10]27 Therefore, cardiovascular events in cancer survivors are related not only to the specific cardiotoxicity of the cancer treatment but also the risk factors attributed to longevity, lifestyle and nutrition, which are intensified by the pathophysiology of the cancer itself.…”

Section: Discussionmentioning

confidence: 99%

“…1,3,4,[7][8][9][10] There is an association between cardiovascular risk factors specific to the individual plus the aggravating factor acquired from the cancer's pathophysiology and the side effects of oncological treatments. In this context, cardiotoxicity is defined as the effects of external agents (chemical or physical) that negatively interfere with the heart, causing structural, electrical, and functional changes to the myocardium.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the costs and quality of cardiovascular care in oncological monitoring

Costa

Hyeda

2016

Rev. Assoc. Med. Bras.

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Summary Objective: To analyze the health care costs specifically related to cardiovascular diseases, which were spent by patients of a private healthcare provider in southern Brazil, after their diagnosis of cancer. Method: We developed an observational, cross-sectional, retrospective study, with a qualitative-quantitative strategy, through the activity of analytical internal audit of medical accounts. Results: 860 accounts from 2012 to 2015 were analyzed, 73% referred to female users, with average age of 62.38 years, and a total direct cost of BRL 241,103.72. There was prevalence of 37% of breast cancer, 15% of prostate cancer and 9% of colon cancer. In relation to the cardiovascular care, 44% were consultations, 44% were complementary exams, 10% were emergency care, and 3% were hospitalizations. Regarding the health care costs with cardiovascular services, higher costs were in hospitalizations (51%), followed by complementary exams (37%), consultations (8%) and emergency care (4%). Conclusion: The cancer survivors commonly use health care in other specialties such as cardiology, and the main cost refers to hospitalization. It is recommended to invest in prevention (consultation and complementary exam) as well as in programs of chronic disease management to reduce costs and improve the quality of health care.

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“…Surgery remains the only curative therapy for GC treatment, and perioperative and adjuvant chemotherapy can improve the outcome (4,5). However, no clear superiority of one strategy over others has been observed, and serious side effects and dose-limiting toxicities of chemotherapy treatments are common (6). In addition, >50% of resected GC patients experience reccurrence and metastases (7).…”

Section: Introductionmentioning

confidence: 99%

Trametes robiniophila may induce apoptosis and inhibit MMPs expression in the human gastric carcinoma cell line MKN-45

Pan

et al. 2016

Oncology Letters

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Abstract. Gastric carcinoma (GC) is one of the most common malignant tumors and is mainly treated by invasive surgeries. The present study aimed to investigate the treatment potential of Trametes robiniophila on GC using the human GC cell line MKN-45. Cells were incubated with Trametes robiniophila at a concentration of 0, 5 and 10 mg/ml for 24 h. The apoptosis of the cell line was examined with acridine orange/ethidium bromide staining and flow cytometry. The expression of B-cell lymphoma (Bcl)-2, Fas, caspase-3, matrix metalloproteinase (MMP)-2 and MMP-9 was analyzed using reverse transcription-polymerase chain reaction and western blotting. With increasing drug concentrations, the proportion of apoptotic and necrotic cells increased. For a certain concentration, the apoptotic ratio also increased with increasing response times. Compared with the control group, the Bcl-2, MMP-2 and MMP-9 expression levels in the MKN-45 cell line decreased, while the expression levels of Fas and caspase-3 increased (P<0.05), and the expression patterns were strengthened with increasing drug concentrations. The present study revealed that Trametes robiniophila had treatment potential on GC, and it may act on gastric cells through apoptotic induction and MMPs expression inhibition. Based on the present results, Trametes robiniophila may be considered as an alternative approach for noninvasive therapy of GC. However, future studies should be performed to clarify this further.

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Cardiac side-effects of cancer chemotherapy

Cited by 390 publications

References 116 publications

Cytotoxicity of Trichoderma spp. Cultural Filtrate Against Human Cervical and Breast Cancer Cell Lines

Cytotoxicity of Trichoderma spp. Cultural Filtrate Against Human Cervical and Breast Cancer Cell Lines

Analysis of the costs and quality of cardiovascular care in oncological monitoring

Trametes robiniophila may induce apoptosis and inhibit MMPs expression in the human gastric carcinoma cell line MKN-45

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