A 65-year-old female known to have type 2 diabetes, with no significant past medical history, had presented to another hospital with a 2-week history of progressive dyspnoea, orthopnoea and, lower limb oedema. Echocardiography revealed a large pericardial effusion with echocardiographic signs of increased intrapericardial pressure. An emergency pericardiocentesis was performed. After 1 week, the patient was admitted to King Fahd Military Medical Complex (Dhahran, Saudi Arabia) because of re-accumulation of the large pericardial effusion, which mandated another pericardiocentesis. CT of the chest revealed enlarged mediastinal lymph nodes. Video-assisted thoracic surgery was performed to obtain a pericardial window and a biopsy from the mediastinal lymph nodes, which revealed non-caseating granuloma, highly suggestive of sarcoidosis. A few days after surgery the patient experienced a neurogenic bladder, acute renal shutdown, and metabolic acidosis, during which she developed stress-induced cardiomyopathy that improved a few days later. The patient’s symptoms improved within 2 weeks after receiving corticosteroids.