Cardiac Sarcoidosis

Tan, Jian Liang; Fong, Hee Kong; Birati, Edo Y.; Han, Yuchi

doi:10.1016/j.amjcard.2018.10.021

Cited by 67 publications

(75 citation statements)

References 45 publications

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“…The development of caseating granulomas and tissue scarring represent the typical features of sarcoidosis, a systemic inflammatory disease that involves multiple organs and apparatus with an US annual prevalence of 10.9−35.5/100.000 in African-Americans and a cardiac involvement in 25% of subclinical patients [19]. A wide range of manifestations characterizes cardiac sarcoidosis (CS), the most common including complete heart block and right bundle branch block, ventricular arrhythmias and sudden cardiac death [20]. Diagnosis is challenging as ECG abnormalities are shown in just 3.2-8.6% of patients with clinically silent CS [20], and diagnostic criteria include different imaging modalities and histological confirmation [19].…”

Section: Cardiac Sarcoidosismentioning

confidence: 99%

Cardiovascular magnetic resonance (CMR) in restrictive cardiomyopathies

et al. 2020

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The restrictive cardiomyopathies constitute a heterogeneous group of myocardial diseases with a different pathogenesis and overlapping clinical presentations. Diagnosing them frequently poses a challenge. Echocardiography, electrocardiograms and laboratory tests may show non-specific changes. In this context, cardiac magnetic resonance (CMR) may play a crucial role in defining the diagnosis and guiding treatments, by offering a robust myocardial characterization based on the inherent magnetic properties of abnormal tissues, thus limiting the use of endomyocardial biopsy. In this review article, we explore the role of CMR in the assessment of a wide range of myocardial diseases causing restrictive patterns, from iron overload to cardiac amyloidosis, endomyocardial fibrosis or radiation-induced heart disease. Here, we emphasize the incremental value of novel relaxometric techniques such as T1 and T2 mapping, which may recognize different storage diseases based on the intrinsic magnetic properties of the accumulating metabolites, with or without the use of gadolinium-based contrast agents. We illustrate the importance of these CMR techniques and their great support when contrast media administration is contraindicated. Finally, we describe the useful role of cardiac computed tomography for diagnosis and management of restrictive cardiomyopathies when CMR is contraindicated.

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Section: Cardiac Sarcoidosismentioning

confidence: 99%

Cardiovascular magnetic resonance (CMR) in restrictive cardiomyopathies

et al. 2020

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“…4.3). Cardiac involvement is clinically manifest in about 5% of patients with sarcoidosis (sarcoid granulomas can be clinically silent), while it is asymptomatic in about 25% of cases, as confirmed by pathology, i.e., autopsy studies [126,127], and imaging series, either CMR or fluorodeoxyglucose positron emission tomography (PET) [128,129]. Simultaneous PET/MR increases the diagnostic accuracy and offers complementary information on disease pathophysiology [129,130].…”

Section: Sarcoidosismentioning

confidence: 99%

“…It is unusual for patients to manifest cardiac involvement at onset. Cardiologists are more likely to be involved in the clinical management of patients diagnosed with the disease [126]. Myocarditis is not specifically mentioned in the complex phenotype of the disease, but pericarditis is a known possible complication and myocardial involvement and cardiac infiltration have been reported in early-onset sarcoidosis associated with CARD15 mutations [140,141].…”

Section: Familial Monogenic Sarcoidosis: the Blau Syndrome And Early-mentioning

confidence: 99%

Genetic Basis of Myocarditis: Myth or Reality?

et al. 2020

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“…Fatigue and depression are common in patients with sarcoidosis, often not fully acknowledged by treating clinicians, with little high-quality evidence for treatment. 43,44 It is also possible that there are other causes for her symptoms, including unrecognised cardiac sarcoidosis, 45,46 pulmonary hypertension, 47 or sleep apnoea. 48 Unfortunately, no perfect tool exists to assess sarcoidosis activity.…”

Section: Third-line Treatmentmentioning

confidence: 99%

Pulmonary Sarcoidosis: A Clinical Update

Mathur

Dempsey

2020

Journal of the Royal College of Physicians of Edinburgh

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Education Sarcoidosis remains dif cult to diagnose, assess and treat. The last decade has brought signi cant diagnostic and therapeutic advances in the eld of sarcoidosis including endobronchial ultrasound, 18 F-uorodeoxyglucose positron emission tomography and biologics. In this article we use clinical vignettes to discuss commonly encountered cases to illustrate and explain the application of these, and other advances.

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Cardiac Sarcoidosis

Cited by 67 publications

References 45 publications

Cardiovascular magnetic resonance (CMR) in restrictive cardiomyopathies

Cardiovascular magnetic resonance (CMR) in restrictive cardiomyopathies

Genetic Basis of Myocarditis: Myth or Reality?

Pulmonary Sarcoidosis: A Clinical Update

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