Cardiac Reverse Remodeling in Ischemic Heart Disease with Novel Therapies for Heart Failure with Reduced Ejection Fraction

Leancă, Sabina Andreea; Afrăsânie, Irina; Crișu, Daniela; Matei, Iulian Theodor; Duca, Ștefania Teodora; Costache, Alexandru Dan; Onofrei, Viviana; Tudorancea, Ionuț; Mitu, Ovidiu; Bădescu, Magda; Șerban, Lăcrămioara Ionela; Costache, Irina Iuliana

doi:10.3390/life13041000

Cited by 4 publications

(1 citation statement)

References 177 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Не изучены изменения адреномедуллина, системы предсердного натрийуретического пептида, регулирующего патологическую активизацию ренин-ангиотензин-альдостероновой системы и симпатического отдела вегетативной нервной системы. Углубление фундаментальных знаний о вибрационно-опосредованной патологии определяет не только развитие и внедрение новых методов исследования в клинику профессиональной патологии, но и точки-мишени для фармакологического воздействия лекарственных препаратов, способных тормозить и вызывать регресс структурного ремоделирования миокарда и сосудов, как то ингибиторы ангиотензинпревращающего фермента, блокаторы ангиотензиновых рецепторов в комбинации с ингибитором неприлизина [67][68][69][70][71], блокаторы кальциевых каналов [72], а также пероральные сахароснижающие лекарственные средства [73,74].…”

Section: заключениеunclassified

Mechanisms of vibration-induced structural myocardial remodeling

Vorobieva,

Levchenkova,

Lenskaya

et al. 2024

Rev Clin Pharm Drug Ther

View full text Add to dashboard Cite

The review presents literature data analysis devoted to the study of structural changes in the heart in patients with vibration disease, identified by echocardiographic methods in the form of concentric remodeling of the left ventricle chambers and disturbance of its diastolic function, a decrease in the intensity of the heart structure work compared to healthy ones in 1.2 times (p0.05). The changes in morphometric and bioenergetic parameters of cardiomyocytes against the background of various experimental vibration modes (7 and 56 sessions with a frequency of 8 Hz) confirms the violation of the ideal relationship between the spatial configuration of the heart cavities, the ability to contract and the energy supply potential. The loss of cardiac myofibrils symbolizes the convertion of myocardial hypertrophy to the decompensation stage and the increase in degenerative (dystrophic) signs, in particular the loss of sarcomeres of cardiomyocytes. To realize the processes of pathological structural (morphological) and energy restructuring of tissue under the influence of vibration-mediated hemodynamic and ischemic factors, it is necessary to involve in the process numerous mediators that regulate metabolism, proliferation, growth and survival of cells, such as STIM (stromal interaction molecule), SERCA (calcium ATPase of the endo(sarco)plasmic reticulum), IP3R (inositol-1,4,5-triphosphate receptor), Orai (protein that forms CRAC channels), TRPC (transient receptor potential canonical), etc. As one of the most important link of structural cardiac remodeling is performed by the degradation system of the extracellular matrix, including matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), which regulate the rate of mRNA synthesis on the DNA matrix by binding to specific DNA regions that control cardiac nutrition and plasticity. A lot of analyzed facts make it possible to explain some patterns of the development of cardiac remodeling in patients with vibration disease and to determine the direction of pathogenetically based approaches to therapy, taking into account not only the vibration-protective effect of drugs, but also their ability to inhibit and regress myocardial remodeling.

show abstract

Section: заключениеunclassified

Mechanisms of vibration-induced structural myocardial remodeling

Vorobieva,

Levchenkova,

Lenskaya

et al. 2024

Rev Clin Pharm Drug Ther

View full text Add to dashboard Cite

show abstract

Benefits of sacubitril/valsartan administration and physical training in cardiac rehabilitation: current trends and bibliometric analysis of the years 2015-2024

Iovanovici,

Dogaru,

Nistor – Cseppento

et al. 2024

Balneo and PRM Research Journal

View full text Add to dashboard Cite

Introduction. Heart failure, with its economic and social burden and increasing incidence in the general population, is a global problem. Since 2015, a new class of drugs with angiotensin and neprilysin re-ceptor inhibitory action, namely the combination of sacubitril and valsartan (S/V), has been introduced in the treatment of HF. The study aimed to perform a bibliometric analysis of the available knowledge and assess research trends through quantitative analysis of the literature related to the use of S/V and physical training in HF. Methods. In the study, we used the Web of Science database, period 2015-January 2024. The data obtained was processed with Vos viewer and Microsoft Excel. The results obtained and their interpretation provided an overview of the most relevant and prolific journals, countries, authors, and organizations. Conclusion. After marketing approval, the publication trend was upward until 2023, when the number of publica-tions decreased significantly. Our study shows that although the number of publications de-creased, updates of treatment guidelines were published, and a significant number of articles supporting the benefits of S/V treatment in chronic HF (with reduced or preserved ejection frac-tion) but also in acute forms were published. Although the number of articles on cardiac rehabilitation is low, this is highlighted in treatment guidelines and studies have emerged assessing the reasons why patients do not follow a cardiac rehabilitation programme. Cardiac rehabilitation is important for its physiological benefits: improving VO2max, myocardial blood flow and endothelial function. Health policies should be put in place to raise awareness of the importance of cardiac rehabilitation, including distances to a rehabilitation centre. Keywords: sacubitril/valsartan; heart failure; cardiac rehabilitation; bibliometric analysis

show abstract

Chronic systolic heart failure: association of remodeling of the right heart and renal dysfunction with cardiac arrhythmias

Molchanova,

Ivannikov,

Musaeva

et al. 2024

Medicinskij alfavit

View full text Add to dashboard Cite

Introduction. Ischemic (ICMP) and dilated cardiomyopathy (DCMP) are the leading causes of chronic heart failure (CHF) with the most frequent indication for heart transplantation. The similarity of these diseases consists in the widespread and high mortality rate due to pathological remodeling of both the left and right chambers of the heart, which is accompanied by the progression of CHF, increasing the risk of sudden cardiac death.The purpose of the study. To study the relationship of systolic function of the left ventricle (LV) with remodeling of the right heart, renal dysfunction and their relationship with cardiac arrhythmia.Materials and methods. The study included 72 patients with CHF with reduced ejection fraction (CHFrEF), who were being treated at the N. V. Sklifosovsky Scientific Research Institute of EM in connection with worsening CHF. Group I consisted of 48 patients with DCMP; group II – 24 patients with ICMP.Results. LV ejection fraction (LV EF) in patients of both groups was <30 %, but it was significantly lower in group I (p=0.001). The EF of the right ventricle (RV) in group I was low and amounted to 24.6 [19.5; 28.5]%. In group I, the volume of the right atrium (PP) and the size of the pancreas correlated with LV EF (r= –0.489, p=0.015 and r= –0.410, p=0.005, respectively); each subsequent increase in the volume of right atrium (RA) by 1 ml increased the likelihood of atrial fibrillation (AF) by 1.018 times (OR: 1.018, 95 % CI: 1.0042–1.033, p=0.011). The estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 increased the chances of ventricular tachycardia (VT) by 9.5 times (OR: 9.5, 95 % CI: 2.32–38.87, p=0.002). Each subsequent decrease in eGFR by 1 ml/min/1.73 m2 increased the chances of developing VT by 1.03 times (OR: 0.967, 95 % CI: 0.937–0.988, p=0.036)].Conclusions. In patients with CHFrEF, regardless of the etiology, a decrease in LV EF leads to structural and functional changes in the right parts of the heart. In individuals with DCMP, an increase in RA volume by 1 ml increases the likelihood of AF by 1.018 times; a decrease in eGFR by 1 ml/min/1.73 m2 increases the chances of developing VT by 1.03 times.

show abstract

Cardiac Reverse Remodeling in Ischemic Heart Disease with Novel Therapies for Heart Failure with Reduced Ejection Fraction

Cited by 4 publications

References 177 publications

Mechanisms of vibration-induced structural myocardial remodeling

Mechanisms of vibration-induced structural myocardial remodeling

Benefits of sacubitril/valsartan administration and physical training in cardiac rehabilitation: current trends and bibliometric analysis of the years 2015-2024

Chronic systolic heart failure: association of remodeling of the right heart and renal dysfunction with cardiac arrhythmias

Contact Info

Product

Resources

About