Cardiac Resynchronization Therapy:

Boriani, Giuseppe; Fallani, Francesco; Martignani, Cristian; Biffi, Mauro; Saporito, Davide; Greco, Cristiano; Ziacchi, Matteo; Levorato, Maurizio; Pontone, Giulia; Valzania, Cinzia; Diemberger, Igor; Franchi, Roberto; Branzi, Angelo

doi:10.1111/j.1540-8159.2005.00005.x

Cited by 26 publications

(22 citation statements)

References 19 publications

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“…We identified seventeen studies, which reported parameters of baseline RV function and LVEF (Figure 1) [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. One study was not included in the final analysis, as it did not provide data in terms of absolute number (and standard deviation) for baseline RV function parameters and LVEF before and after CRT [19].…”

Section: Resultsmentioning

confidence: 99%

“…One study was not included in the final analysis, as it did not provide data in terms of absolute number (and standard deviation) for baseline RV function parameters and LVEF before and after CRT [19]. Sixteen studies were selected for final analysis [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Details of the studies and baseline characteristics are summarized in Table 1 Previous studies have reported conflicting effects of baseline RV function on response to CRT.…”

Section: Resultsmentioning

confidence: 99%

“…Details of the studies and baseline characteristics are summarized in Table 1 Previous studies have reported conflicting effects of baseline RV function on response to CRT. Almost a decade ago, in a small study (n=15), Boriani et al reported that RV dysfunction as assessed by radionuclide angiography did not determine relative benefits of CRT [7]. Later, Burri et al, reported that patients with baseline RV dysfunction (defined as RVEF≤35% by radionuclide angiography) were less likely to respond to CRT as assessed by improvement in NYHA classification, 6 minute walking distance and LVEF after a mean follow up of 9 months [8].…”

Section: Resultsmentioning

confidence: 99%

“…However, studies have reported conflicting results, and the relationship of baseline RV function with response to CRT remains unclear [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. In this study, we performed a meta-analysis of published studies and investigated the relationship of various baseline echocardiographic parameters of RV function with response to CRT, as assessed by change in LV ejection fraction (EF).…”

Section: Introductionmentioning

confidence: 99%

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Meta-Analysis of the Relation of Baseline Right Ventricular Function to Response to Cardiac Resynchronization Therapy

Sharma

Bax

Vallakati

et al. 2016

The American Journal of Cardiology

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Meta-Analysis of the Relation of Baseline Right Ventricular Function to Response to Cardiac Resynchronization Therapy

Sharma

Bax

Vallakati

et al. 2016

The American Journal of Cardiology

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“…In einer Vielzahl von kleineren Studien und im CRT-Arm der MIRACLE-Studie konnte nun bereits gezeigt werden, dass CRT zu einem «reversen linksventrikulären remodeling» mit Verkleinerung der enddiastolischen und endsystolischen Volumina und Diameter und damit auch zu einer Reduktion der Mitralinsuffizienz führt [9][10][11][12][13]. Bei näherer Betrachtung der Überlebenskurven aus der COMPANION-Studie wird ersichtlich, dass sich der Vorteil der CRT-Gruppe gegenüber der medikamentös therapierten Gruppe erst nach ungefähr 8 Monaten herauskristallisiert.…”

Section: Days After Randomizationunclassified

Kardiale Resynchronisationstherapie (CRT): mit oder ohne ICD-back-Up?

2006

Schweiz Ärzteztg

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Cardiac Resynchronisation Therapy (CRT): with or without ICD back-up?The incidence of heart failure is increasing and patients are threatened to die of pump failure as well as of sudden cardiac death (SCD). Lately, cardiac resynchronisation therapy (CRT) has been introduced to treat patients with persistent heart failure and dyssynchronous left ventricular activation evidenced by complete left bundle branch block in the ECG. The COMPANION trial demonstrated, that in patients with an EF <0.35, NYHA class III or IV, and complete left bundle branch block, CRT with and without implantable cardioverter defibrillator (ICD) back-up reduced the combined endpoint of mortality and hospitalisation. A reduction in total mortality could only be achieved by the use of CRT-ICD. The CARE-HF trial randomised similar patients to CRT or medical treatment. The secondary endpoint of death from all causes was reached by significantly fewer patients in the CRT group. However, approximately one third of the deaths was attributable to SCD.To date, there is no trial available comparing the effects of CRT and CRT-ICD on total mortality as a primary endpoint. Apart from the results of the COMPANION trial, several conclusions can be drawn from primary prevention trials in the general ICD population. The SCD-HeFT trial showed a significant mortality reduction in patients with an LVEF 90.35 who received an ICD for primary prevention as compared to placebo and amiodarone. After successful treatment with CRT, the mean LVEF improved from 0.25 to 0.32 in the CARE-HF trial. The majority of patients would therefore continue to fulfil the criteria for ICD-implantation according to the SCDHeFT trial. SCD-HeFT also showed a mortality reduction in patients with NYHA class II but not in those with NYHA class III. It is conceivable, that CRT can change the mode of death from pump failure to SCD. To date, the available data indicate, that an ICD-back-up should at least be considered in every patient eligible for CRT therapy.

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Changes in parameters of right ventricular function with cardiac resynchronization therapy

Sharma

Lavie²,

Vallakati

et al. 2017

Clinical Cardiology

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Background Studies have shown that cardiac resynchronization therapy (CRT) significantly improves right ventricle (RV) size and function in patients with heart failure (HF). Hypothesis CRT does not lead to improvement in RV function independent of baseline clinical variables. Methods A systematic search of studies published between 1966 to August 31, 2015 was conducted using Pub Med, CINAHL, Cochrane CENTRAL and the Web of Science databases. Studies reporting tricuspid annular plane systolic excursion (TAPSE) or RV basal strain or RV long axis diameter or RV short axis diameter or RV fractional area change (FAC), before and after CRT, were identified. A meta‐analysis was performed using random effects with inverse variance method to determine the pooled mean difference in various parameters of RV function after CRT. Meta‐regression analysis was performed to test the relationship between change in various parameters of RV functions after CRT and covariates‐ age, QRS duration, and left ventricular ejection fraction (LVEF). Results Thirteen studies (N=1541) were selected for final analysis. CRT therapy led to statistically significant increases in TAPSE [1.21 (95% CI 0.55‐1.86; p<0.001)], RV FAC [2.26 (95% CI 0.50‐4.01; p<0.001)] and basal strain [2.82 (95% CI 0.59‐5.05; p<0.001)] and statistically significant decreases in mean RV long axis diameter [‐2.94 (95% CI ‐5.07‐ ‐0.82; p=0.005)] and short axis diameter [‐1.39 (95% CI ‐2.10‐ ‐0.67; p=0.876)] after a mean follow up period of 9 months. However, after meta‐regression analysis for age, QRS duration, and baseline LVEF as covariates, there was no significant improvement in any of the parameters of RV function after CRT. Conclusion There was a statistically significant improvement in TAPSE, RV basal strain, RV fractional area, RV long axis and short axis with CRT. However, improvement in these echocardiographic parameters of RV function after CRT was not independent of baseline clinical variables but statistically dependent on age, QRS duration and baseline LVEF.

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Cardiac Resynchronization Therapy:

Cited by 26 publications

References 19 publications

Meta-Analysis of the Relation of Baseline Right Ventricular Function to Response to Cardiac Resynchronization Therapy

Meta-Analysis of the Relation of Baseline Right Ventricular Function to Response to Cardiac Resynchronization Therapy

Kardiale Resynchronisationstherapie (CRT): mit oder ohne ICD-back-Up?

Changes in parameters of right ventricular function with cardiac resynchronization therapy

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