Cardiac Progenitor Cells in Basic Biology and Regenerative Medicine

Witman, Nevin; Sahara, Makoto

doi:10.1155/2018/8283648

Cited by 26 publications

(20 citation statements)

References 71 publications

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“…IPSC-derived CMs have also been shown to integrate into infarcted guinea pig heart, improving cardiac function and suppressing arrhythmias [ 13 ]. Human iPSC-derived cardiovascular progenitors have been successfully tested more recently in preclinical studies of canine and porcine MI models [ 14 ].…”

Section: Cardiac Generation Of Ipscsmentioning

confidence: 99%

Strategies and Challenges to Improve Cellular Programming-Based Approaches for Heart Regeneration Therapy

Jiang

Liang

Huang

et al. 2020

IJMS

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Limited adult cardiac cell proliferation after cardiovascular disease, such as heart failure, hampers regeneration, resulting in a major loss of cardiomyocytes (CMs) at the site of injury. Recent studies in cellular reprogramming approaches have provided the opportunity to improve upon previous techniques used to regenerate damaged heart. Using these approaches, new CMs can be regenerated from differentiation of iPSCs (similar to embryonic stem cells), the direct reprogramming of fibroblasts [induced cardiomyocytes (iCMs)], or induced cardiac progenitors. Although these CMs have been shown to functionally repair infarcted heart, advancements in technology are still in the early stages of development in research laboratories. In this review, reprogramming-based approaches for generating CMs are briefly introduced and reviewed, and the challenges (including low efficiency, functional maturity, and safety issues) that hinder further translation of these approaches into a clinical setting are discussed. The creative and combined optimal methods to address these challenges are also summarized, with optimism that further investigation into tissue engineering, cardiac development signaling, and epigenetic mechanisms will help to establish methods that improve cell-reprogramming approaches for heart regeneration.

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Section: Cardiac Generation Of Ipscsmentioning

confidence: 99%

Strategies and Challenges to Improve Cellular Programming-Based Approaches for Heart Regeneration Therapy

Jiang

Liang

Huang

et al. 2020

IJMS

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“…However, there is still no reliable therapy for acute cardiac conditions like myocardial infarction (MI), which account for nearly half of all cardiovascular deaths in the industrialized world [1,2]. Regenerative medicine-based strategies for infarcted myocardium have shown promise in preclinical animal models as well as early clinical trials [3]. Whilst these have demonstrated some physiological improvements in ventricular function, they were associated with very low cell retention after some weeks, suggesting a paracrine effect of transplanted cells rather than functional integration within the damaged tissue [4].…”

Section: Cardiac Regeneration-a Problem To Solve or A Solution With Pmentioning

confidence: 99%

“…Several studies have demonstrated that the cells generated from CPCs, particularly cardiomyocytes, display an immature phenotype similar to that of embryonic cardiac cells [3]. However, when the CPCs are transplanted into a host environment, the differentiated cells reach a more advanced maturity, such as greater organisation of sarcomeres and formation of gap junctions (in the case of cardiomyocytes) and development of tubular-like structures (for smooth muscle and endothelial cells) [11,24,27,28].…”

Section: Tissue Engineering With Cpcs and Cpc-derived Cardiomyocytesmentioning

confidence: 99%

“…Furthermore, the populations of CPC-derived cells are heterogeneous and frequently represent immature cells, which could potentially lead to arrhythmias, lower long-term stability and poor integration when transplanted [3,300]. The mechanisms involved in cardiac lineage subtype specification will need to be fully investigated and optimised to produce purer and more mature populations of the desired cell types from the CPCs.…”

Section: Current Challenges and Limitationsmentioning

confidence: 99%

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Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials

Barreto

Hamel

Schiatti

et al. 2019

Cells

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Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac function in patients affected by heart disease or heart failure. CPCs are proliferative and committed to cardiac fate, capable of generating cells of all the cardiac lineages. These cells offer a significant shift in paradigm over the use of human induced pluripotent stem cell (iPSC)-derived cardiomyocytes owing to the latter’s inability to recapitulate mature features of a native myocardium, limiting their translational applications. The iPSCs and direct reprogramming of somatic cells have been attempted to produce CPCs and, in this process, a variety of chemical and/or genetic factors have been evaluated for their ability to generate, expand, and maintain CPCs in vitro. However, the precise stoichiometry and spatiotemporal activity of these factors and the genetic interplay during embryonic CPC development remain challenging to reproduce in culture, in terms of efficiency, numbers, and translational potential. Recent advances in biomaterials to mimic the native cardiac microenvironment have shown promise to influence CPC regenerative functions, while being capable of integrating with host tissue. This review highlights recent developments and limitations in the generation and use of CPCs from stem cells, and the trends that influence the direction of research to promote better application of CPCs.

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“…In this context, also CPCs-derived exosomes are able to exert, once released in the extracellular microenvironment, positive therapeutic effects through multiple mechanisms interacting with different target cells, such as endothelial cells and cardiomyocytes [72][73][74] . Overall, despite all these encouraging results many critical issues, including the challenges of electrical coupling, undetermined mechanism aspects and, above all, the long term engraftment and survival of injected cells, should be addressed before CPCs could be considered as a strong therapeutic tool for regenerative medicine applications [75] .…”

Section: Adult Cpcsmentioning

confidence: 99%

CPCs and ECM: A Good Mix for Cardiac Regeneration

2018

Med One

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Despite several improvements in term of diagnosis and prevention, ischemic heart disease still represents one of the principal worldwide causes of death. Cardiac progenitor cells (CPCs) based therapy is considered a valid alternative to heart transplant, but several issues concerning the transplanted cells viability, retention and therapeutic effect need to be solved. Tissue engineering, mixing synthetic or natural polymers with injected cells, could represent the way through which overcomes shortages and set up an effective cardiac regenerative therapy. Nowadays, it is well known that cardiac extracellular matrix (ECM) provides structural and functional integrity, affects cardiac function, development and physiologic repair. In this optic, ECM and ECM-like materials represent functional and biocompatible tools with a great potential to serve as natural or nature-mimicking scaffolds in the field of regenerative medicine. The aim of the present work is to provide an overview on the state of the art and recent advantages on CPCs and scaffold-based therapy for heart regeneration.

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Cardiac Progenitor Cells in Basic Biology and Regenerative Medicine

Cited by 26 publications

References 71 publications

Strategies and Challenges to Improve Cellular Programming-Based Approaches for Heart Regeneration Therapy

Strategies and Challenges to Improve Cellular Programming-Based Approaches for Heart Regeneration Therapy

Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials

CPCs and ECM: A Good Mix for Cardiac Regeneration

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