Cardiac positron emission tomography imaging

Macháč, Josef

doi:10.1053/j.semnuclmed.2004.09.002

Cited by 156 publications

(131 citation statements)

References 114 publications

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“…Validation of the use of 82 Rb/PET myocardial perfusion imaging to study cardiovascular function related to blockage of the coronary artery has been previously reported [42,43]. In spite of the relatively short physical half-life of 82 Rb, the PET imaging studies were successful and showed comparable or improved detection of myocardial perfusion in patients with coronary artery diseases [44][45][46]. The convenience of using a generator system for routine imaging has fueled the expansion of PET imaging application in nuclear cardiology.…”

Section: Autoradiography In Normal and Infarct Rat Heart Modelsmentioning

confidence: 99%

A novel gallium bisaminothiolate complex as a myocardial perfusion imaging agent

Plößl

Chandra

Qü

et al. 2008

Nuclear Medicine and Biology

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The development of new myocardial perfusion imaging agents for positron emission tomography (PET) may improve the resolution and quantitation of changes in regional myocardial perfusion measurement. It is known that a 68 Ge/ 68 Ga generator can provide a convenient source of PET tracers because of the long physical half-life of 68 Ge (271 days). A new ligand, 7,8-dithia-16,24-diazatrispiro[5.2.5.2.5.3] pentacosa-15,24-diene, which consists of a N 2 S 2 -chelating core incorporated into three cyclohexyl rings, was prepared. To test feasibility and potential utility, the N 2 S 2 ligand was successfully labeled and tested with 67 Ga (half-life=3.26 day; γ=93.3, 184.6 and 300.2 keV), which showed >92% radiochemical purity. The corresponding "cold" Ga complex was synthesized, and its structure containing a pyramidal N 2 S 2 chloride core was elucidated with X-ray crystallography. In vivo biodistribution of this novel 67 Ga complex, evaluated in normal rats, exhibited excellent heart uptake and retention, with 2.1% and 0.9% initial dose/organ at 2 and 60 min, respectively, after an intravenous injection. Autoradiography was performed in normal rats and in rats that had the left anterior descending coronary artery permanently ligated surgically. Autoradiography showed an even uptake of activity in the normal heart, and there was a distinctively lower uptake in the damaged side of the surgically modified heart. In conclusion, the new N 2 S 2 ligand was readily prepared and labeled with radioactive 67 Ga. Biodistribution in rats revealed high initial heart uptake and relatively high retention reflecting regional myocardial perfusion.

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Section: Autoradiography In Normal and Infarct Rat Heart Modelsmentioning

confidence: 99%

A novel gallium bisaminothiolate complex as a myocardial perfusion imaging agent

Plößl

Chandra

Qü

et al. 2008

Nuclear Medicine and Biology

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“…Il est actuellement disponible aux USA dans 2 sociétés (Bristol Myers Squibb et Eastern Isotopes) à un coût encore excessif. La spécificité du rubidium-82 a été démontrée supérieure à celle du thallium et du technétium du fait de la correction d'atténuation plus efficace avec un émetteur de photons de 511 keV (Machac, 2005). Sa courte période physique permet d'injecter de fortes activités (1,85 GBq) au malade et de répéter l'examen 10 minutes plus tard pour des épreuves pharmacologiques.…”

Section: (B) Radionucléides éMetteurs De Positonsunclassified

Radioprotection associée aux nouvelles évolutions, diagnostiques et thérapeutiques, en médecine nucléaire

Aubert

Chatal

2006

Radioprotection

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ArticleRadioprotection associée aux nouvelles évolutions, diagnostiques et thérapeutiques, en médecine nucléaire . Regarding exposure nuclear medicine personnel, the amount of radioactivity used for therapeutic purposes is currently limited to 740 MBq, which requires that the patient be kept in a shielded room. Radiation exposure can be roughly estimated by measuring the exposure rate (in µSv/h) delivered at a distance of 1 meter from a source of one MBq. When considering both the exposure rate and half-life, it appears that similar doses of iron-52, yttrium-86, and iodine-124 deliver a high dose rate immediately after injection and during the following few hours. Current regulations on environmental exposure limit radioactivity levels in hospital sewage outfalls to 1000 Bq/L, for technetium 99m, and 100 Bq/L, for iodine-131. Forthcoming regulations for other radionuclides should not be established solely based on general rules such as the 100 Bq/L limit. Impact studies similar to those required in the nuclear industry, should be conducted.

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“…When compared with the gold standard of invasive coronary angiography, cardiac PET, using 31N ammonia and 18 RB, has demonstrated an overall sensitivity of 93% and specificity of 92% when diagnosing coronary artery disease. 37 In comparison to SPECT, Go and colleagues showed a 95% sensitivity and 82% specificity for 82RB PET compared to a 79% and 76% respectively for SPECT. 38 In assessing myocardial viability, the intent is to determine whether areas of poorly perfused myocardium are still alive and hence may benefit from revascularization.…”

Section: Pet In Cardiologymentioning

confidence: 99%

PET in Halifax

Chung¹,

Zoost²,

Burrell³

2011

DMJ

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With the recent installation of a PET-CT scanner in Halifax, local clinicians may now take advantage of PET's various applications in the field of oncology, where it has become a standard of care. PET also plays a role in the areas of cardiology and neurology although it has not yet been approved for these uses in Nova Scotia. This article describes the basic principles of PET and radiopharmaceuticals as well as PET's increasing role in the management of patients in the areas of oncology, neurology and cardiology. PET shows significant promise in these areas and clinicians should be familiar with its many applications.

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Cardiac positron emission tomography imaging

Cited by 156 publications

References 114 publications

A novel gallium bisaminothiolate complex as a myocardial perfusion imaging agent

A novel gallium bisaminothiolate complex as a myocardial perfusion imaging agent

Radioprotection associée aux nouvelles évolutions, diagnostiques et thérapeutiques, en médecine nucléaire

PET in Halifax

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