Cardiac Pericytes

Das, Mitali; Chung, Mina K.

doi:10.1016/j.jacbts.2023.01.010

Cited by 1 publication

(1 citation statement)

References 10 publications

(19 reference statements)

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“…COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and affects various organs, including the heart, brain, and lungs [156][157][158][159]. Cardiac pericytes, which express high levels of angiotensin-converting enzyme 2 (ACE-2), the main receptor for SARS-CoV-2, are major targets for viral infection [160][161][162]. The infection of pericytes via SARS-CoV-2 contributes to cardiac complications associated with COVID-19, such as thrombosis, inflammation, and hemodynamic disturbances [163].…”

Section: Pericyte Loss In Covid-19mentioning

confidence: 99%

Pericyte Loss in Diseases

2023

Cells

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Pericytes are specialized cells located in close proximity to endothelial cells within the microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls, and maintaining the integrity of the blood–brain barrier. The loss of pericytes has been associated with the development and progression of various diseases, such as diabetes, Alzheimer’s disease, sepsis, stroke, and traumatic brain injury. This review examines the detection of pericyte loss in different diseases, explores the methods employed to assess pericyte coverage, and elucidates the potential mechanisms contributing to pericyte loss in these pathological conditions. Additionally, current therapeutic strategies targeting pericytes are discussed, along with potential future interventions aimed at preserving pericyte function and promoting disease mitigation.

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Section: Pericyte Loss In Covid-19mentioning

confidence: 99%

Pericyte Loss in Diseases

2023

Cells

View full text Add to dashboard Cite

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Cardiac Pericytes

Cited by 1 publication

References 10 publications

Pericyte Loss in Diseases

Pericyte Loss in Diseases

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