Cardiac perfusion changes in patients treated for breast cancer with radiation therapy and doxorubicin: preliminary results

Hardenbergh, Patricia H.; Munley, Michael T.; Bentel, Gunilla C.; Kedem, Ronit; Borges‐Neto, Salvador; Hollis, Donna; Prosnitz, Leonard R.; Marks, Lawrence B.

doi:10.1016/s0360-3016(00)01531-5

Cited by 160 publications

(100 citation statements)

References 24 publications

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“…The presence of perfusion defects in patients with breast cancer after therapy has been documented [27][28][29], and it is now well established that SPECT myocardial perfusion predicts cardiac events in patients with cancer [30]. In many series, the prevalence of perfusion defects was quite high [27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Intima-media thickness, myocardial perfusion and laboratory risk factors of atherosclerosis in patients with breast cancer treated with anthracycline-based chemotherapy

et al. 2010

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An increased incidence of complications of atherosclerosis has been noted in cancer survivors. The aim of the present study was to evaluate, in patients with breast carcinoma, the effect of antracycline-based chemotherapy on carotid intima-media thickness (IMT), myocardial perfusion, assessed by single-photon emission tomography (SPECT) and laboratory parameters associated with the risk of atherosclerosis. Thirty-six patients with breast cancer were evaluated before and after anthracycline-based chemotherapy. Retinol, alpha-tocopherol, glycosylated hemoglobin and urinary neopterin were measured by high-performance liquid chromatography. Peripheral blood cell count, D-dimers, fibrinogen, antithrombin, glucose, magnesium, creatinine, uric acid, albumin, C-reactive protein, lipoprotein (a), cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, homocysteine, urinary albumin and N-acetyl-beta-D-glucosaminidase (NAG) were determined with routine methods. No significant differences were observed between patients and 16 controls. Compared to the measurement before the start of therapy, peripheral blood leukocyte and platelet count, hemoglobin, creatinine, HDL cholesterol, retinol, albumin, urinary albumin and NAG decreased, and total cholesterol, LDL cholesterol, triglycerides, neopterin and mean IMT increased significantly after the treatment. Of the 36 patients who had SPECT after treatment, perfusion defects were noted only in two cases, including the patient who had perfusion defects at baseline examination and a patient who did not have a baseline SPECT. In conclusion, a significant increase in carotid IMT, total cholesterol, LDL cholesterol, triglycerides and urinary neopterin and a decrease of peripheral blood leukocyte and platelet counts, hemoglobin, creatinine, HDL cholesterol, retinol, albumin and NAG were observed after the treatment.

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Section: Discussionmentioning

confidence: 99%

Intima-media thickness, myocardial perfusion and laboratory risk factors of atherosclerosis in patients with breast cancer treated with anthracycline-based chemotherapy

et al. 2010

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“…1,2,[9][10][11][12]17 However, its interaction with radiation to potentiate cardiotoxicity is unknown. 6 In this study, only the area of the cardiac silhouette in the initial radiation field was statistically significant among the possible risk factors for an increase in the CTR. Total radiation dose was not a significant risk factor.…”

Section: Discussionmentioning

confidence: 56%

“…8 Hardenbergh et al reported a high incidence of cardiac perfusion defects in patients who received radiotherapy plus doxorubicin compared with those without doxorubicin. 6 5-FU also has a cardiotoxic effect 15,16 and is commonly used to treat esophageal cancer. 1,2,[9][10][11][12]17 However, its interaction with radiation to potentiate cardiotoxicity is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 As the survival rate after radiation therapy increases, management of the late adverse effects of radiation becomes increasingly important. Although there are many investigations of radiation-induced heart disease after irradiation for Hodgkin's disease and breast cancer, [3][4][5][6][7][8] there are few reports of the incidence after irradiation for esophageal cancer, 9,10 and the risk factors are unclear. This study investigated the incidence and risk factors of enlargement of the cardiac silhouette on chest radiographs as a late adverse effect of radiation therapy for esophageal cancer.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for enlargement of cardiac silhouette on chest radiography after radiotherapy for esophageal cancer

et al. 2006

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“…On the other hand Giordano et al found no difference in cardiac morbidity in left sided versus right sided breast cancer patients treated with new RT techniques [7]. Multiple studies have detected myocardial perfusion abnormalities in the heart corresponding with the RT field in left sided breast cancer patients even with modern RT techniques [10][11][12]. Some of these defects developed as early as 6 months after RT.…”

Section: Introductionmentioning

confidence: 99%

The clinical implications of myocardial perfusion abnormalities in patients with esophageal or lung cancer after chemoradiation therapy

Gayed

Gohar

Liao

et al. 2009

Int J Cardiovasc Imaging

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Cardiac perfusion changes in patients treated for breast cancer with radiation therapy and doxorubicin: preliminary results

Cited by 160 publications

References 24 publications

Intima-media thickness, myocardial perfusion and laboratory risk factors of atherosclerosis in patients with breast cancer treated with anthracycline-based chemotherapy

Intima-media thickness, myocardial perfusion and laboratory risk factors of atherosclerosis in patients with breast cancer treated with anthracycline-based chemotherapy

Risk factors for enlargement of cardiac silhouette on chest radiography after radiotherapy for esophageal cancer

The clinical implications of myocardial perfusion abnormalities in patients with esophageal or lung cancer after chemoradiation therapy

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