Cardiac Papillary Fibroelastoma: Case report and review of the literature

Khair, Tarif; Mazidi, Peyman; Laos, Luis F.

doi:10.1016/j.ijcard.2008.06.092

Cited by 9 publications

(5 citation statements)

References 8 publications

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“…Fibroelastomas constitute 75% of all valvular tumors [34]. These tumors are found more commonly on the aortic and mitral valves but tricuspid and pulmonic valve fibroelastomas have been described [1, 34–38]. Typically, fibroclastomas are filiform projections measuring up to 1 cm which are found on the value leaflets or endocardial surface of the valve.…”

Section: Resultsmentioning

confidence: 99%

Cardiac Masses, Part 2: Key Imaging Features for Diagnosis and Surgical Planning

Buckley

Madan

Kwong

et al. 2011

American Journal of Roentgenology

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OBJECTIVE The objectives of this article are to discuss key radiologic features that differentiate primary and secondary cardiac masses. Clinical scenarios are included to highlight stepwise radiologic workup of tumors of the pericardium, epicardium, myocardium, valves, and chambers. The involvement of key cardiac anatomic structures will also be emphasized to determine resectability and guide surgical planning. CONCLUSION Multimodality imaging plays a pivotal role in diagnosis and surgical planning of cardiac masses. Clinical features, such as patient age, location, and imaging characteristics of the mass will determine the likely differential diagnosis. In addition to radiologic evaluation of the mass itself, involvement of valvular apparatus, extent of myocardial involvement, or presence of associated coronary artery involvement is necessary to determine resectability and surgical technique.

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Section: Resultsmentioning

confidence: 99%

Cardiac Masses, Part 2: Key Imaging Features for Diagnosis and Surgical Planning

Buckley

Madan

Kwong

et al. 2011

American Journal of Roentgenology

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“…Clinically most papillary fibroelastomas are asymptomatic, but they possess embolic potential leading to life‐threatening complications such as coronary and cerebral embolism with consequent ischaemic damage or stroke and thus should be resected .…”

Section: Discussionmentioning

confidence: 99%

“…About 75% of these tumours can be classified as benign and 25% as malignant . Of the benign tumours, myxomas have been considered to be the most common entity, followed by lipomas and papillary fibroelastomas . However, contrary to the common doctrine, a recent publication with a large collection of the latter concluded that they might actually be more prevalent than myxomas .…”

Section: Introductionmentioning

confidence: 99%

KRAS mutation in papillary fibroelastoma: a true cardiac neoplasm?

Wittersheim

Heydt

Hoffmann³

et al. 2017

The Journal of Pathology CR

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Primary cardiac tumours are rare and mostly benign lesions. Recent publications report that cardiac papillary fibroelastomas are the most common benign primary heart tumour, outnumbering myxomas. However, there is no consensus about their aetiology. We investigated the molecular profile of these tumours using next generation sequencing in a cohort of 16 cases. Eleven of 14 (79%) analysable tumours showed mutations of the KRAS oncogene. Our results provide unambiguous evidence that a significant proportion of these lesions are genuine neoplastic tumours caused by an oncogenic driver mutation.

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“…These tumours are described as resembling sea anemones with frondlike projections. The atrioventricular and semilunar valves 4–6 are affected with an equal frequency. They have been considered as neoplasms, hamartomas, organized thrombi and unusual endocardial responses to infection or haemodynamic trauma.…”

Section: Discussionmentioning

confidence: 99%