Cardiac Pacing in Sub-Saharan Africa

Jouven, Xavier; Diop, Bouya; Narayanan, Kumar; Adoubi, A.; Bâ, Serigne Abdou; Balde, D; Damorou, Jean-Marie; Diarra, Mamadou Salia; Dzudie, Anastase; Ferreira, Béatriz; Houenassi, Sedonougbo Martin; Ikama, Méo Stéphane; Kané, A.; Kane, Adama; Kingué, Samuel; Mipinda, Jean Bruno; Mocumbi, Ana Olga; Niakara, A.; Ouankou, M.; Sidi, Abdallahi Aly; Takombe, Jean Laurent; Toure, Ibrahim Ali; Zabsonré, Patrice; Celermajer, David S.; Lafont, Antoine; Dodinot, B; Sagnol, Pascal; Marijon, Éloi

doi:10.1016/j.jacc.2019.09.034

Cited by 14 publications

(6 citation statements)

References 22 publications

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“…Notably, the effect of increased HR was marked in the subgroup of patients with hypertension. Despite the variations of etiologies and clinical characteristics of HF globally, a similar effect has been reported in several studies (15)(16)(17). It shall be noted that hypertension has been reported as one of the common causes of HF in SSA (8).…”

Section: Discussionsupporting

confidence: 74%

Resting heart rate predicts all-cause mortality in sub-Saharan African patients with heart failure: a prospective analysis from the Douala Heart failure registry (Do-HF)

Dzudié¹,

Barche²,

Mouliom³

et al. 2021

Cardiovasc Diagn Ther

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Background: Higher resting heart rate (HR) is associated with mortality amongst Caucasians with heart failure (HF), but its significance has yet to be established in sub-Saharan Africans in whom HF differs in terms of characteristics and etiologies. We assessed the association of HR with all-cause mortality in patients with HF in sub-Saharan Africa.Methods: The Douala HF registry (Do-HF) is an ongoing prospective data collection on patients with HF receiving care at four cardiac referral services in Douala, Cameroon. Patients included in this report were followed-up for 12 months from their index admission, for all-cause mortality. We used Cox-regression analysis to study the association of HR with all-cause mortality during follow-up.Results: Of 347 patients included, 343 (98.8%) completed follow-up. The mean age was 64±14 years, 176 (50.7%) were female, and median admission HR was 85 bpm. During a median follow-up of 12 months, 78 (22.7%) patients died. Mortality increased steadily with HR increase and ranged from 12.2% in the lower quartile of HR (≤69 bpm) to 34.1% in the upper quartile of HR (>100 bpm). Hazard ratio of 12-month death per 10 bpm higher HR was 1.16 (1.04-1.29), with consistent effects across most subgroups, but a higher effect in participants with hypertension vs. those without (interaction P=0.044).Conclusions: HR was independently associated with increased risk of all-cause mortality in this study, particularly among participants with hypertension. The implication of this finding for risk prediction or reduction should be actively investigated.

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Section: Discussionsupporting

confidence: 74%

Resting heart rate predicts all-cause mortality in sub-Saharan African patients with heart failure: a prospective analysis from the Douala Heart failure registry (Do-HF)

Dzudié¹,

Barche²,

Mouliom³

et al. 2021

Cardiovasc Diagn Ther

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“…The copyright holder for this this version posted November 26, 2020. ; https://doi.org/10.1101/2020.11.24.20237701 doi: medRxiv preprint several studies [15][16][17]. It shall be noted that hypertension has been reported as one of the common causes of heart failure in SSA [8].…”

Section: Discussionmentioning

confidence: 99%

Resting Heart Rate predicts all-cause mortality in sub-Saharan African Patients with Heart Failure: Insight from the Douala Heart failure registry (Do-HF)

Dzudie

Barche²,

Mouliom

et al. 2020

Preprint

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BackgroundHigher resting heart rate (HR) is associated with mortality amongst Caucasians with heart failure (HF), but its significance has yet to be established in sub-Saharan Africans in whom HF differs in terms of characteristics and etiologies.ObjectivesWe assessed the association of HR with all-cause mortality in patients with HF in sub-Saharan Africa.MethodsThe Douala HF registry (Do–HF) is an ongoing prospective data collection on patients with HF receiving care at four cardiac referral services in Douala, Cameroon. Patients included in this report were followed-up for 12 months from their index admission, for all-cause mortality. We used Cox-regression analysis to study the association of HR with all-cause mortality during follow-up.ResultsOf 347 patients included, 343 (98.8%) completed follow-up. The mean age was 64±14 years, 176 (50.7%) were female, and median admission HR was 85 bpm. During a median follow-up of 12 months, 78 (22.7%) patients died. Mortality increased steadily with HR increase and ranged from 12.2% in the lower quartile of HR (≤69 bpm) to 34.1% in the upper quartile of HR (>100 bpm). Hazard ratio of 12-month death per 10 bpm higher heart rate was 1.16 (1.04–1.29), with consistent effects across most subgroups, but a higher effect in participants with hypertension vs those without (interaction p=0.044).ConclusionHeart rate was independently associated with increased risk of all-cause mortality in this study, particularly among participants with hypertension. The implication of this finding for risk prediction or reduction should be actively investigated.

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“…In a recent analysis of the Africa-Pace program, approximately 50% of 1077 patients for whom PPM was recommended (the predominant indication was complete heart block) died while waiting for the arrival of international medical missions. 1 The median waiting time between diagnosis and intervention was 18.4 months. Even higher mortality rates are suspected in areas where device implantation is not available.…”

Section: Current State Of Cardiac Arrhythmia Care In Resource-constra...mentioning

confidence: 99%

“…Even higher mortality rates are suspected in areas where device implantation is not available. 1 The lack of CIED availability in LMICs will become a more pressing concern as the global population ages. 14 …”

Section: Current State Of Cardiac Arrhythmia Care In Resource-constra...mentioning

confidence: 99%

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Global disparities in arrhythmia care: Mind the gap

Sharif

Ptaszek²

2022

Heart Rhythm O2

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Cardiac Pacing in Sub-Saharan Africa

Cited by 14 publications

References 22 publications

Resting heart rate predicts all-cause mortality in sub-Saharan African patients with heart failure: a prospective analysis from the Douala Heart failure registry (Do-HF)

Resting heart rate predicts all-cause mortality in sub-Saharan African patients with heart failure: a prospective analysis from the Douala Heart failure registry (Do-HF)

Resting Heart Rate predicts all-cause mortality in sub-Saharan African Patients with Heart Failure: Insight from the Douala Heart failure registry (Do-HF)

Global disparities in arrhythmia care: Mind the gap

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