Cardiac pacing and coronary hemodynamics

Kyriakides, Zenon S.; Kolettis, Theofilos M.; Kremastinos, Dimitrios Th.

doi:10.1016/s0033-0620(99)70023-x

Cited by 1 publication

(2 citation statements)

References 53 publications

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“…The larger the LV mass is and the higher the heart rate is, the higher is the CBF. Cardiac pacing is a good method for simulating elevation in heart rate, though the degree of increase in coronary blood flow due to elevation in heart rate caused by cardiac pacing is different from that caused by physical exercise, even if the target heart rate is the same (12). Cardiac pacing is also a good method for precise control of heart rate, when the change in CBF due to increase in heart rate is detected.…”

Section: Discussionmentioning

confidence: 99%

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Different Coronary Blood Flow Increase in Left Ventricular Hypertrophy Due to Hypertension Compared to Hypertrophic Cardiomyopathy at Elevated Heart Rate

et al. 2003

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Coronary vasodilator reserve (CVR) is reduced in patients with left ventricular hypertrophy (LVH). However,it is not clear whether there is any difference between the coronary blood flow increase in LVH caused by hypertension (HTH) and that caused by hypertrophic cardiomyopathy (HCM) when the heart rate increases.In this study, 16 subjects with HTH, 10 subjects with HCM, and 10 subjects with normotension (NT) were investigated. Average peak velocities at rest, at pacing, and at dilatation were measured using a Doppler catheter placed at the left descending coronary artery to calculate coronary blood flow (CBF) and CVR. CVR at rest was identical in the HTH and HCM groups, and in both cases was lower than the resting CVR in NT subjects. There were significant differences in the CVR values at a pacing rate of 120 beats/min among the groups. These values were lowest in HCM, highest in NT, and intermediary in HTH subjects. And the percent increase in CBF in HCM at that pacing rate was higher than that in HTH ( p 0.05) or NT ( p 0.05). There was no difference in the percent increase in CBF at this pacing rate between the HTH and NT groups. The effects of elevated heart rate on the percent increase in CBF were different between the HTH and HCM groups. We

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Section: Discussionmentioning

confidence: 99%

“…Thus, heart rate is an important factor affecting coronary circulation (12). However, it is not known how the disease factor and heart rate factor interact in patients with LVH.…”

Section: Introductionmentioning

confidence: 99%