“…Different mechanisms have been proposed to explain enhanced Pseudomonas pathogenicity, not only in the Cash rat model, but also in human disorders like cystic fibrosis. There has been some speculation, for example, that coating of Pseudomonas by mucoid substances may provide survival advantages in the respiratory tract by protecting the microorganisms from phagocytic cells, antibodies and even antibiotics (4,5,6). The importance of bacterial adherence to the epithelia, before replication and microcolony formation has also been recognized (7).…”