Cardiac Outflow tract septation defects in a DiGeorge syndrome model respond to Minoxidil treatment
Ilaria Aurigemma,
Rosa Ferrentino,
Varsha Poondi Krishnan
et al.
Abstract:Background: The T-BOX transcription factor TBX1 is essential for the development of the pharyngeal apparatus and it is haploinsufficient in DiGeorge syndrome (DGS), a developmental anomaly associated with congenital heart disease and other abnormalities. The murine model recapitulates the heart phenotype and showed collagen accumulation. Methods: We first used a cellular model to study gene expression during cardiogenic differentiation of WT and Tbx1-/- mouse embryonic stem cells. Then we used a mouse model of… Show more
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