Cardiac non‐Hodgkin's lymphoma: clinical characteristics and trends in survival

Abstract

Pathologic lymphomatous involvement of cardiac tissue should be considered in the evaluation of patients with NHL. Durable remissions can be achieved in B-cell NHL with cardiac involvement, and thus, therapy should be considered in such cases.

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“…Intracardiac masses as part of lymphoma are even more unusual, but may occur in disseminated disease (6); cardiac involvement is seen in 10 -15 % of cases of advanced disease upon postmortem (7,8). The right side of the heart is overrepresented in such cases, and the atria are overrepresented compared with the ventricles (6,9). Multiple chambers are usually involved, as in our patient (10,11).…”

“…The more malignant lymphomas, such as diffuse large B-cell lymphoma, Burkitt's lymphoma and some forms of T-cell lymphoma, appear to be overrepresented in cases of cardiac involvement (6,11). Comorbidity in the form of immunosuppression and immunodeficiency, including HIV infection, increases the risk of cardiac affection in lymphoproliferative disorders (5,6,13).…”

“…Fatal outcomes, including myocardial perforation, have been described, and the diagnosis is often first established upon autopsy (6,9,14). Treatment modalities include chemotherapy, radiotherapy and surgery.…”

Primary Cardiac T Cell Lymphoma Mimicking ST-Elevation Myocardial Infarction

“…Potential heart transplantation can be considered [15]. Median survival is 3 months among patients with biopsy-proven cardiac NHL, with some rare instances of remission and cure [2]. The patient in this case received CHOP chemotherapy without any surgical resection of the mass.…”

“…Primary cardiac T cell lymphoma (PCTL) is exceedingly rare, with <20 biopsy-proven cases having been reported worldwide [2]. Cardiac presentation of PCTL can range from benign to the most common being clinical heart failure.…”