Cardiac Natriuretic Peptide Response to Water Restriction in the Hormonal Adaptation of Two Semidesert Rodents from West Africa (Steatomys caurinus, Taterillus gracilis)

Lacas, S; Allevard, A. M.; Ag'Atteinine, S; Gallo-Bona, Noëlle; Gauquelin‐Koch, Guillemette; Hardin‐Pouzet, Hélène; Gharib, C; Sicard, Bruno; Maurel, Daniel

doi:10.1006/gcen.2000.7545

Cited by 35 publications

(6 citation statements)

References 33 publications

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“…However, hydration/dehydrationdependent processes may also play a role, as suggested by the fluctuations in cardiac ANP content and plasma levels experienced by water-deficiency-tolerant mammals. In the desert rat (Lacas et al, 1998;Lacas et al, 2000) and the dromedary camel (Osman et al, 2004), NP-dependent mechanisms significantly contribute to coping with these environmental challenges. Notably, in the camel, intensive rehydration after a long period of water deprivation does not increase blood volume, the water being first stored in the rumen-like forestomach and then directed to the interstitium.…”

Section: Np From Ontogeny To Physio-pathology: the Mammalian Lessonmentioning

confidence: 99%

Catecholamines, cardiac natriuretic peptides and chromogranin A: evolution and physiopathology of a ‘whip-brake’ system of the endocrine heart

Tota

Cerra

Gattuso

2010

Journal of Experimental Biology

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Summary In the past 50 years, extensive evidence has shown the ability of vertebrate cardiac non-neuronal cells to synthesize and release catecholamines (CA). This formed the mindset behind the search for the intrinsic endocrine heart properties, culminating in 1981 with the discovery of the natriuretic peptides (NP). CA and NP, co-existing in the endocrine secretion granules and acting as major cardiovascular regulators in health and disease, have become of great biomedical relevance for their potent diagnostic and therapeutic use. The concept of the endocrine heart was later enriched by the identification of a growing number of cardiac hormonal substances involved in organ modulation under normal and stress-induced conditions. Recently, chromogranin A (CgA), a major constituent of the secretory granules, and its derived cardio-suppressive and antiadrenergic peptides, vasostatin-1 and catestatin, were shown as new players in this framework, functioning as cardiac counter-regulators in ‘zero steady-state error’ homeostasis, particularly under intense excitatory stimuli, e.g. CA-induced myocardial stress. Here, we present evidence for the hypothesis that is gaining support, particularly among human cardiologists. The actions of CA, NP and CgA, we argue, may be viewed as a hallmark of the cardiac capacity to organize ‘whip-brake’ connection-integration processes in spatio-temporal networks. The involvement of the nitric oxide synthase (NOS)/nitric oxide (NO) system in this configuration is discussed. The use of fish and amphibian paradigms will illustrate the ways that incipient endocrine-humoral agents have evolved as components of cardiac molecular loops and important intermediates during evolutionary transitions, or in a distinct phylogenetic lineage, or under stress challenges. This may help to grasp the old evolutionary roots of these intracardiac endocrine/paracrine networks and how they have evolved from relatively less complicated designs. The latter can also be used as an intellectual tool to disentangle the experimental complexity of the mammalian and human endocrine hearts, suggesting future investigational avenues.

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Section: Np From Ontogeny To Physio-pathology: the Mammalian Lessonmentioning

confidence: 99%

Catecholamines, cardiac natriuretic peptides and chromogranin A: evolution and physiopathology of a ‘whip-brake’ system of the endocrine heart

Tota

Cerra

Gattuso

2010

Journal of Experimental Biology

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“…This situation may be an appropriate adaptation to survival in the absence of free water. In a follow up study, Lacas et al (2000) observed that water deprivation for eight days increased cardiac ANP, but decreased plasma ANP levels in the slender gerbil (Taterillus gracillus) which is a desert rodent. However, in another species, the northwestern fat mouse (Steatomys caurinus), cardiac and plasma ANP levels were unaffected by water deprivation.…”

Section: Natriuretic Peptidesmentioning

confidence: 99%

The effect of water deprivation on signalling molecules that utilise cGMP in the spinifex hopping mouse Notomys alexis.

Heimeier¹,

Bartolo²,

Donald³

2004

Aust. Mammalogy

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In mammals the natriuretic and guanylin peptides influence renal and intestinal fluid content and electrolyte transport by binding to and activating guanylyl cyclase (GC) receptors that in turn stimulate production of the intracellular second messenger guanosine 3?:5?-cyclic monophospate (cGMP). However, the role of natriuretic and guanylin peptides in desert mammals is not understood. The spinifex hopping-mouse (Notomys alexis), has a suite of behavioural and physiological mechanisms that permits survival for extended periods without access to free water. Because signalling molecules that generate cGMP are known to promote water excretion, it was predicted that natriuretic and guanylin peptide synthesis would be down regulated in water-deprived N. alexis, and thus reduce the amount of water lost in the urine and faeces. However, in the kidney ANP and GC-A mRNA levels were increased in water-deprived mice, but CNP and GC-B mRNA levels were decreased. Water deprivation increased guanylin and uroguanylin mRNA expression in the distal colon, but it remained unchanged in the kidney and proximal colon. The expression of GC-C mRNA increased in the proximal colon but not in the distal colon. This study shows that water deprivation differentially affects the expression of regulatory molecules that stimulate cGMP production, and that a down-regulation associated with water conservation does not uniformly occur.

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“…Plasma osmolality is often unaffected in many small desert mammals in experimental conditions when they are water-deprived, which indicates that they can compensate to remain in water balance and do not become dehydrated (see Degen 1997 ; Heimeier et al 2004 ; Heimeier and Donald 2006 ). Several processes have been described for maintaining body water content; including the production of metabolic water from body fat, the antidiuretic effect of AVP on urine concentration, and the extensive use of intracellular water (Horowitz and Adler 1983 ; Sicard 1987 ; Sicard 1992 ; Lacas et al 2000 ).…”

Section: Discussionmentioning

confidence: 99%

Vasopressin and oxytocin expression in hypothalamic supraoptic nucleus and plasma electrolytes changes in water-deprived male Meriones libycus

Boumansour

Benhafri

Guillon

et al. 2021

Animal Cells and Systems

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In mammals, plasmatic osmolality needs to be stable, and it is highly related to the hydric state of the animals which depends on the activity of the hypothalamic neurohypophysial system and more particularly by vasopressin secretion. Meriones, a desert rodent, can survive even without drinking for more than one month. The mechanism(s) by which they survive under these conditions remains poorly understood. In this study, we examine the water's deprivation consequences on the: (1) anatomy, morphology, and physiology of the hypothalamic supraoptic nucleus, (2) body mass and plasma electrolytes changes in male desert rodents 'Meriones libycus' subjected to water deprivation for 30 days. The effect of water deprivation was evaluated on the structural and cellular organization of the supraoptic nucleus by morphological observations and immunohistochemical approaches, allowing the labeling of AVP but also oxytocin. Our finding demonstrated that upon water deprivation (1) the body weight decreased and reached a plateau after a month of water restriction. (2) The plasmatic osmolality began to decrease and return to values similar to control animals at day 30. (3) The SON, both in hydrated and water-deprived animals, is highly developed.(4) The AVP labeling in the SON increased upon dehydration at variance with OT. These changes observed in body mass and plasma osmolality reveal an important adaptive process of male Meriones in response to prolonged water deprivation. Overall, this animal represents an interesting model for the study of water body homeostasis and the mechanisms underlying the survival of desert rodents to xeric environments.

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Cardiac Natriuretic Peptide Response to Water Restriction in the Hormonal Adaptation of Two Semidesert Rodents from West Africa (Steatomys caurinus, Taterillus gracilis)

Cited by 35 publications

References 33 publications

Catecholamines, cardiac natriuretic peptides and chromogranin A: evolution and physiopathology of a ‘whip-brake’ system of the endocrine heart

Catecholamines, cardiac natriuretic peptides and chromogranin A: evolution and physiopathology of a ‘whip-brake’ system of the endocrine heart

The effect of water deprivation on signalling molecules that utilise cGMP in the spinifex hopping mouse Notomys alexis.

Vasopressin and oxytocin expression in hypothalamic supraoptic nucleus and plasma electrolytes changes in water-deprived male Meriones libycus

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