Cardiac MRI correlates of diastolic left ventricular function assessment by echocardiography

Saba, Shahryar G.; Chung, Sohae; Tseng, Stephanie; Bhagavatula, Sharath K.; Donnino, Robert; Srichai, Monvadi B.; Sarić, Muhamed; Katz, Stuart; Axel, Leon

doi:10.1186/1532-429x-15-s1-e53

Cited by 3 publications

(6 citation statements)

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“…The maximum velocity of the AVJ in early diastole reflects peak mitral annulus recoil velocity during passive LV filling. We previously showed that AVJ MVED represents a statistically significant CMR correlate of tissue Doppler echocardiography E’ [ 5 ], and we have confirmed these findings in a separate cohort of patients from a different institution. We analyzed 27 patients who underwent both studies within 24 hours, and again found a statistically significant (p = 0.001) correlation between CMR-derived MVED and E’ (r = 0.624) [ 6 ].…”

Section: Introductionsupporting

confidence: 83%

“…This variable is measured from the AVJ normalized velocity-versus-time curve, which is derived by measuring the slope between sequential time points on the normalized displacement-versus-time curve. As we previously showed, MVED represents a statistically significant CMR correlate of mitral annulus E’ measured by tissue Doppler echocardiography [5]. Since we normalized the displacement measurements to the end-diastolic longitudinal LV length, MVED also approximately corresponds to maximum early diastolic strain rate measured by tissue Doppler.…”

Section: Discussionmentioning

confidence: 87%

“…The maximum normalized velocity of the AVJ during early passive mitral filling (MVED), and the best-fit line of normalized AVJ velocity in diastasis (VDS) were also calculated. In order to establish intra-study reliability, AVJ motion analysis was also performed in a previously described cohort of patients referred for CMR [ 5 ] using both 3- and 4-chamber long axis cine images.…”

Section: Methodsmentioning

confidence: 99%

“…Inter-reader variability analysis was performed on the healthy volunteer cohort data obtained by two independent observers. To assess intra-study reproducibility, intraclass correlation coefficients were also obtained in a separate cohort of patients that was previously described [ 5 ]. SPSS Statistics Version 20 was used to carry out all statistical analysis.…”

Section: Methodsmentioning

confidence: 99%

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A novel and practical cardiovascular magnetic resonance method to quantify mitral annular excursion and recoil applied to hypertrophic cardiomyopathy

Saba

Chung

Bhagavatula

et al. 2014

Journal of Cardiovascular Magnetic Resonance

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BackgroundWe have developed a novel and practical cardiovascular magnetic resonance (CMR) technique to evaluate left ventricular (LV) mitral annular motion by tracking the atrioventricular junction (AVJ). To test AVJ motion analysis as a metric for LV function, we compared AVJ motion variables between patients with hypertrophic cardiomyopathy (HCM), a group with recognized systolic and diastolic dysfunction, and healthy volunteers.MethodsWe retrospectively evaluated 24 HCM patients with normal ejection fractions (EF) and 14 healthy volunteers. Using the 4-chamber view cine images, we tracked the longitudinal motion of the lateral and septal AVJ at 25 time points during the cardiac cycle. Based on AVJ displacement versus time, we calculated maximum AVJ displacement (MD) and velocity in early diastole (MVED), velocity in diastasis (VDS) and the composite index VDS/MVED.ResultsPatients with HCM showed significantly slower median lateral and septal AVJ recoil velocities during early diastole, but faster velocities in diastasis. We observed a 16-fold difference in VDS/MVED at the lateral AVJ [median 0.141, interquartile range (IQR) 0.073, 0.166 versus 0.009 IQR -0.006, 0.037, P < 0.001]. Patients with HCM also demonstrated significantly less mitral annular excursion at both the septal and lateral AVJ. Performed offline, AVJ motion analysis took approximately 10 minutes per subject.ConclusionsAtrioventricular junction motion analysis provides a practical and novel CMR method to assess mitral annular motion. In this proof of concept study we found highly statistically significant differences in mitral annular excursion and recoil between HCM patients and healthy volunteers.

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Section: Introductionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A novel and practical cardiovascular magnetic resonance method to quantify mitral annular excursion and recoil applied to hypertrophic cardiomyopathy

Saba

Chung

Bhagavatula

et al. 2014

Journal of Cardiovascular Magnetic Resonance

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“…However, there still lacks simple, validated CMR technique to quantitatively measure the AVJ deformation. Previously, Saba et al (23,24) used a four-chamber cine view to calculate the lateral AVJ displacement. The correlation between mitral velocity early diastole and peak early diastolic velocity of the lateral MA from transthoracic echocardiography was r ϭ 0.362 in 50 patients and r ϭ 0.624 in a separate cohort of 27 patients.…”

Section: Cardiovascular Magnetic Resonance-derived Atrioventricular Junction (Avj) Velocities Correlate Significantly With Tissue Dopplermentioning

confidence: 99%

Automated quantitative assessment of cardiovascular magnetic resonance-derived atrioventricular junction velocities

Leng

Zhao

Huang

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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The assessment of atrioventricular junction (AVJ) deformation plays an important role in evaluating left ventricular systolic and diastolic function in clinical practice. This study aims to demonstrate the effectiveness and consistency of cardiovascular magnetic resonance (CMR) for quantitative assessment of AVJ velocity compared with tissue Doppler echocardiography (TDE). A group of 145 human subjects comprising 21 healthy volunteers, 8 patients with heart failure, 17 patients with hypertrophic cardiomyopathy, 52 patients with myocardial infarction, and 47 patients with repaired Tetralogy of Fallot were prospectively enrolled and underwent TDE and CMR scan. Six AVJ points were tracked with three CMR views. The peak systolic velocity (Sm1), diastolic velocity during early diastolic filling (Em), and late diastolic velocity during atrial contraction (Am) were extracted and analyzed. All CMR-derived septal and lateral AVJ velocities correlated well with TDE measurements (Sm1: r = 0.736; Em: r = 0.835; Am: r = 0.701; Em/Am: r = 0.691; all p < 0.001) and demonstrated excellent reproducibility [intrastudy: r = 0.921-0.991, intraclass correlation coefficient (ICC): 0.918-0.991; interstudy: r = 0.900-0.970, ICC: 0.887-0.957; all p < 0.001]. The evaluation of three-dimensional AVJ motion incorporating measurements from all views better differentiated normal and diseased states [area under the curve (AUC) = 0.918] and provided further insights into mechanical dyssynchrony diagnosis in HF patients (AUC = 0.987). These findings suggest that the CMR-based method is feasible, accurate, and consistent in quantifying the AVJ deformation, and subsequently in diagnosing systolic and diastolic cardiac dysfunction.

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Evaluation of atrioventricular junction velocity by orthogonal polynomial fitting from cine magnetic resonance imaging and comparison with tissue Doppler Echocardiography

Zhao

Tan

Wong

et al. 2014

2014 IEEE Conference on Biomedical Engineering and Sciences (IECBES)

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Cardiac MRI correlates of diastolic left ventricular function assessment by echocardiography

Cited by 3 publications

References 0 publications

A novel and practical cardiovascular magnetic resonance method to quantify mitral annular excursion and recoil applied to hypertrophic cardiomyopathy

A novel and practical cardiovascular magnetic resonance method to quantify mitral annular excursion and recoil applied to hypertrophic cardiomyopathy

Automated quantitative assessment of cardiovascular magnetic resonance-derived atrioventricular junction velocities

Evaluation of atrioventricular junction velocity by orthogonal polynomial fitting from cine magnetic resonance imaging and comparison with tissue Doppler Echocardiography

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