Cardiac MRI Assessment of Mouse Myocardial Infarction and Regeneration

Wu, Yijen

doi:10.1007/978-1-0716-0668-1_8

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The Applications Of Mno 2 Nanomaterials In Disease Diagnosis1

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2023

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Cited by 2 publications

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“…Gdchelated contrast agents have been employed in MRI scans of MI to provide higher contrast enhancements at the infarcted sites approximately 10 to 15 minutes after administration since they clear more slowly from the infarcted area than from the normal myocardium. 152,153 Nevertheless, Gd-chelated contrast agents cannot distinguish between MI sites and edema areas, 154 and require high dose injections, increasing the risk of nephrogenic fibrosis. 155,156 Thus, new contrast agents for the diagnosis of AMI are called for.…”

Section: The Applications Of Mno 2 Nanomaterials In Disease Diagnosismentioning

confidence: 99%

Advances in the application of manganese dioxide and its composites for theranostics

Hao

Zhao

et al. 2023

Inorg. Chem. Front.

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Section: The Applications Of Mno 2 Nanomaterials In Disease Diagnosismentioning

confidence: 99%

Advances in the application of manganese dioxide and its composites for theranostics

Hao

Zhao

et al. 2023

Inorg. Chem. Front.

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Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus

et al. 2023

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Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac disease in humans. In mice, reovirus infects the intestine and disseminates systemically to cause serotype-specific patterns of disease in the brain. To identify receptors conferring reovirus serotype-dependent neuropathogenesis, we conducted a genome-wide CRISPRa screen and identified paired immunoglobulin-like receptor B (PirB) as a receptor candidate. Ectopic expression of PirB allowed reovirus binding and infection. PirB extracelluar D3D4 region is required for reovirus attachment and infectivity. Reovirus binds to PirB with nM affinity as determined by single molecule force spectroscopy. Efficient reovirus endocytosis requires PirB signaling motifs. In inoculated mice, PirB is required for maximal replication in the brain and full neuropathogenicity of neurotropic serotype 3 (T3) reovirus. In primary cortical neurons, PirB expression contributes to T3 reovirus infectivity. Thus, PirB is an entry receptor for reovirus and contributes to T3 reovirus replication and pathogenesis in the murine brain.

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Cardiac MRI Assessment of Mouse Myocardial Infarction and Regeneration

Cited by 2 publications

References 141 publications

Advances in the application of manganese dioxide and its composites for theranostics

Advances in the application of manganese dioxide and its composites for theranostics

Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus

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