Cardiac Metastasis from Carcinoma of the Cervix: Report of Two Cases

Lemus, Julio F.; Abdulhay, Gazi; Sobolewski, Craig; Risch, Victor R.

doi:10.1006/gyno.1998.5009

Cited by 32 publications

(32 citation statements)

References 27 publications

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“…As for the immediate cause of death, cases in which tumor emboli of the lungs led to death have been reported, similar to our case [6, 10, 11]. If the emboli had been found and treated earlier, the symptoms could have been alleviated and the patient's prognosis could have been improved.…”

Section: Discussionsupporting

confidence: 84%

“…The primary tumors of cardiac metastases are often malignant melanoma, malignant lymphoma, leukemia, lung cancer, and breast cancer. Cases of gynecological malignancy are relatively infrequent [4, 5] and are rarely diagnosed before death [6]. The prognosis of a metastatic heart tumor is poor; the average life expectancy of patients with this diagnosis is less than six months.…”

Section: Discussionmentioning

confidence: 99%

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A Case of Cardiac Metastasis from Uterine Cervical Carcinoma

Okamoto

Kusumoto

Seki

et al. 2015

Case Reports in Obstetrics and Gynecology

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Cases of cardiac metastasis from uterine cervical carcinoma are rare. While they are occasionally found on autopsy, antemortem recognition is extremely rare. We confirmed a case of cardiac metastasis from cervical carcinoma antemortem, because we observed a decrease in platelet count during the course of treatment. The patient was a 27-year-old woman diagnosed with stage Ib1 uterine cervical carcinoma. Radical hysterectomy with pelvic lymphadenectomy was performed. Para-aortic lymph node metastasis was detected on positron emission tomography/computed tomography (PET-CT). Adjuvant chemotherapy was started, and most of the metastatic lesions disappeared. Pelvic lymph node recurrence was suspected on PET-CT during continued chemotherapy; therefore, treatment was shifted to radiation therapy. Tumor shrinkage was recognized, and the initial therapy was completed. A noticeable decrease in platelet count was recognized seven months after treatment. Multidetector CT was performed, and an intracardiac tumor was detected. The patient did not desire any further treatment. She died three weeks after the intracardiac tumor was confirmed. Few previous autopsy studies have reported cardiac metastasis from cervical carcinoma. Thus, it is necessary to consider the possibility of cardiac metastasis for patients diagnosed with terminal cervical carcinoma.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

A Case of Cardiac Metastasis from Uterine Cervical Carcinoma

Okamoto

Kusumoto

Seki

et al. 2015

Case Reports in Obstetrics and Gynecology

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“…One is embolic tumor seeding by hematogenous spread or by invasion through the thoracic duct into the right side of the heart (Lemus et al 1998). Another is direct invasion through the lymphatics of the heart (Kountz 1993).…”

Section: Discussionmentioning

confidence: 99%

“…The clinical diagnosis of metastatic carcinoma to the heart is difficult because there are no early symptoms (Labib et al 1992, Lemus et al 1998. Dyspnea and symptoms of pericarditis may be noted.…”

Section: Discussionmentioning

confidence: 99%

“…Other forms of presentation are cardiac arrhythmias and sudden death (Dickens et al 1992), as observed in cases 2 and 3. A non-invasive workup (echocardiography) is often useful in searching for evidence of metastasis (Prichard 1951, Cohen et al 1955, Malaret & Aliaga 1968, Franssila 1975, Charles et al 1977, Labib et al 1992, Kountz 1993, Nelson & Rose 1993, Batchelor et al 1997, Larsimont et al 1998, Lemus et al 1998. Cardiac metastasis from all types of cancer has a poor prognosis, and in most cases survival is limited to a few weeks or months.…”

Section: Discussionmentioning

confidence: 99%

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Cardiac metastasis from primary anaplastic thyroid carcinoma: report of three cases and a review of the literature.

Giuffrida¹,

Gharib²

2001

Endocrine-Related Cancer

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Background: Clinically evident cardiac metastases from malignant neoplasms are uncommon. The frequency of thyroid metastasis to the heart is very low. To our knowledge, over the last 20 years only a few cases have been reported in the entire literature. Metastatic cardiac involvement occurs most often during the terminal stage. Patients: We present three cases of anaplastic thyroid cancer with metastatic involvement of the heart. Results: Two of the patients died from cardiac problems. The absence of early symptoms makes the clinical diagnosis of metastatic carcinoma difficult. Conclusions: Anaplastic thyroid cancer is an aggressive cancer with a dismal prognosis. It should be borne in mind as a source of cardiac metastasis and a cause of cardiac death.

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Role of palliative radiotherapy in the management of mural cardiac metastases: who, when and how to treat? A case series of 10 patients

et al. 2016

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Cardiac metastases (CM), although a rare manifestation of metastatic cancer, are increasing in incidence with the improved prognosis and increased longevity of many patients with cancer. This condition may be life‐threatening, especially for bulky rapidly growing tumors. Such cancer presentations may be amenable to palliative radiotherapy to improve symptoms and to prevent further cardiac function decline. Here, we report on our experience with 10 patients with mural CM who received radiotherapy (RT) to the heart with palliative intent. The radiation treatment was given in different clinical situations using different dose and fractionation, and with a variety of outcomes. Palliative RT was a reasonably effective treatment, leading to good radiographic response in five patients who were evaluable for radiologic response. The mean duration of response in responding patients was 6.3 months (range: 3–11 months). This report describing clinical dilemmas around CM radiation therapy summarizes the previous experiences with radiation in treatment of CM and may assist in the considerations of palliative treatment for these patients.

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Cardiac Metastasis from Carcinoma of the Cervix: Report of Two Cases

Cited by 32 publications

References 27 publications

A Case of Cardiac Metastasis from Uterine Cervical Carcinoma

A Case of Cardiac Metastasis from Uterine Cervical Carcinoma

Cardiac metastasis from primary anaplastic thyroid carcinoma: report of three cases and a review of the literature.

Role of palliative radiotherapy in the management of mural cardiac metastases: who, when and how to treat? A case series of 10 patients

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