Cardiac metastasis from carcinoid tumour: Magnetic resonance imaging findings

Puvaneswary, M; Thomson, Duncan; Bellamy, Greg

doi:10.1111/j.0004-8461.2004.01323.x

Cited by 10 publications

(9 citation statements)

References 15 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While echocardiography has been the primary technique for identifying myocardial metastases from carcinoid tumors, other methods have also been described in the literature. Puvaneswary et al described the use of magnetic resonance imaging for localization of cardiac metastases[ 3 ], while Yeung et al reviewed the use of 111 Indium-pentetreotide scintigraphy. [ 4 ] In this case, scintigraphy demonstrated radiotracer uptake in the region of the heart while MRI scans provided important anatomic information enabling use of focused radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

External beam irradiation of myocardial carcinoid metastases: a case report

et al. 2007

View full text Add to dashboard Cite

The heart is an exceedingly rare site of metastatic involvement in carcinoid tumors. Only nineteen cases have been described in the literature over the past 30 years. We report here on a patient who presented with progressive carcinoid syndrome despite surgical resection of her liver metastases. She was found to have cardiac metastases on inidium-111-pentetreotide scintigraphy and subsequently underwent external beam radiation to the heart resulting in symptomatic palliation of her syndrome and objective radiographic response. To our knowledge, this is the first reported case of metastatic cardiac carcinoid treated with external beam irradiation.

show abstract

Section: Discussionmentioning

confidence: 99%

External beam irradiation of myocardial carcinoid metastases: a case report

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Some cardiac metastases only present as wall thickening and may be difficult to identify with echocardiography. As a single method, MRI is superior to echocardiography in the detection and quantification of cardiac metastases [25,[39][40][41] . Octreoscan or SPECT/CT may be helpful in somatostatin-receptor-positive lesions [23,42] , but when used alone lacks fine discrimination and cannot provide definitive anatomical localization.…”

Section: Imagingmentioning

confidence: 99%

ENETS Consensus Guidelines for the Management of Brain, Cardiac and Ovarian Metastases from Neuroendocrine Tumors

et al. 2010

View full text Add to dashboard Cite

“…1 In contrast to the Puvaneneswary et al case, this metastasis is myocardial in origin and not arising from the pericardium. Metastatic tumors to the heart are relatively uncommon and are usually associated with carcinomas of the lung, breast, and melanomas.…”

mentioning

confidence: 62%

Metastatic Midgut Carcinoid to the Heart Demonstrated on Cardiac Magnetic Resonance Imaging

Pasieka¹,

Schnell²,

Abdel-Aty³

et al. 2009

American Journal of Clinical Oncology

View full text Add to dashboard Cite

A 53-year-old man presented with vague abdominal cramps, pain, diarrhea, and increasing weight loss. He underwent colonoscopy and an abdominal computed tomography scan that demonstrated a mass in the cecum and liver lesions. At laparotomy, peritoneal seeding and liver metastases were found. The pathology revealed a well-differentiated neuroendocrine carcinoma (NET) arising from multiple small bowel tumors.On assessment in a multidisciplinary NET clinic, he had a classic type 3 carcinoid flush. There was a loud 3/6 holosystolic murmur at the lower left sternal border, increasing with inspiration. He had an elevated u5-hydroxyindoleacetic acid, 118 mol/L (normal Ͻ41) and an elevated chromogranin A 290 ng/mL (normal, 6 -39). A magnetic resonance imaging (MRI) scan of abdomen demonstrated multiple hypervascular liver lesions and retroperitoneal lymph node enlargement. Both his metaiodo-benzylguanidine and octreotide scans ( Fig. 1) confirmed multiple liver lesions, a lesion in the left anterior chest lesion. An echocardiogram demonstrated a cardiac mass arising from the right side of the ventricular septum that did not interfere with ventricular flow and moderate tricuspid regurgitation consistent with carcinoid heart disease. A cardiac MRI scan (Fig. 2) demonstrating a 4.1 ϫ 4.1 cm mass arising from the interventricular septum and protruding into the right ventricle.Patient was placed on both short-acting and long-acting (LAR) somatostatin analogue. He underwent 3 cycles of I 131 metaiodo-benzylguanidine therapy (4443 MGq each cycle), before reassessment. Eighteen months after his presentation, he is symptomatically controlled on 30 mg of LAR, and his cardiac examination is unchanged.To our knowledge, this is the second reported case of carcinoid metastases to the heart seen on cardiac MRI imaging. 1 In contrast to the Puvaneneswary et al case, this metastasis is myocardial in origin and not arising from the pericardium. Metastatic tumors to the heart are relatively uncommon and are usually associated with carcinomas of the lung, breast, and melanomas. Since 1985 when the first report of myocardial metastases from NET was reported, there have only been 26 reported cases in the literature. 2 Pandya et al reported 11 patients with myocardial metastases, in which the right ventricle was involved in 40%, the left ventricle in 53%, and the ventricular septum in 7%. 3

show abstract

Cardiac metastasis from carcinoid tumour: Magnetic resonance imaging findings

Abstract: A case of myocardial metastasis from a gastrointestinal carcinoid is presented. The colon was the primary site. The patient did not manifest symptoms of carcinoid syndrome and had no echocardiographic or MRI evidence of carcinoid valvular heart disease.

Cited by 10 publications

References 15 publications

External beam irradiation of myocardial carcinoid metastases: a case report

External beam irradiation of myocardial carcinoid metastases: a case report

ENETS Consensus Guidelines for the Management of Brain, Cardiac and Ovarian Metastases from Neuroendocrine Tumors

Metastatic Midgut Carcinoid to the Heart Demonstrated on Cardiac Magnetic Resonance Imaging

Contact Info

Product

Resources

About