Cardiac mechanoenergetic cost of elevated plasma viscosity after moderate hemodilution

Chatpun, Surapong; Cabrales, Pedro

doi:10.3233/bir-2010-0574

Cited by 10 publications

(15 citation statements)

References 37 publications

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“…7A). In our previous study, baseline blood viscosity (52% Hct) was 4.71 ± 0.62 cP and blood viscosity after hemodilution with dextran 70kDa (28% Hct) was 3.09 ± 0.09 cP (Chatpun and Cabrales 2010). These values were used to calculate MVR, thus it magnified the changes in blood vessel diameters.…”

Section: Resultsmentioning

confidence: 90%

“…Left ventricular blood volume was measured continuously in conductance units (RVU; relative volume unit) and converted to actual blood volume (μl) at the end of the experiment (Chatpun and Cabrales 2010). The blood conductance at the baseline was estimated from baseline hematocrit, using the pooling data of blood conductance and hematocrit relationship.…”

Section: Methodsmentioning

confidence: 99%

“…As the cardiovascular system is made up of microvascular subsystems arranged in parallel and series, it is expected that the beneficial effects observed in the skinfold microvascular tissue will produce an improvement in the entire circulatory system, thus affecting cardiac function. HVPE improved load-dependent cardiac function indices in combination with higher stroke work, compared to baseline and LVPE in an acute hemodilution model (Chatpun and Cabrales 2010). Therefore, increasing plasma viscosity enhances cardiac function and requires higher energy consumption, limiting the advantages of HVPE especially to situations where oxygen is a limiting factor.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, real-time ventricular pressure volume measurements using closed-chest method have been introduced in small animals. In our studies we have implemented a miniaturized pressure-volume (PV) conductance catheter that provides the simultaneous measurements of ventricular pressure and volume in experimental small animal models, leading to a powerful approach to quantify cardiac function in physiological environment (Chatpun and Cabrales 2010,Shioura, et al 2007,Pacher, et al 2008,Pacher, et al 2004). …”

Section: Introductionmentioning

confidence: 99%

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Exogenous intravascular nitric oxide enhances ventricular function after hemodilution with plasma expander

Chatpun

Cabrales

2012

Life Sciences

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Aims This study evaluated the hypothesis that exogenous nitric oxide (NO) supplementation during acute hemodilution with plasma expander (PE) provides beneficial effects on cardiac function. Main methods Acute hemodilution in golden Syrian hamsters was induced by a 40% of blood volume exchange with dextran 70 kDa. Intravascular NO supplementation after hemodilution was accomplished with a NO donor, diethylenetriamine NONOate (DETA NONOate). The test group was treated with DETA NONOate, while the control group received only vehicle. Left ventricular cardiac function was studied using pressure-volume measurements obtained with a miniaturized conductance catheter. Key findings Cardiac output increased to 122 ± 5% and 107 ± 1% of the baseline in the group treated with NO donor and the vehicle group, respectively. Stroke work per stroke volume (SW/SV) after hemodilution reduced to 90% of the baseline and the NO donor significantly reduced SW/SV compared to the vehicle. The minimum rate of pressure change (dP/dtmin) was significantly lower in animals treated with the NO donor compared to vehicle treated animals. Systemic vascular resistance (SVR) decreased to 62 ± 5% of the baseline in the NO donor group, whereas the vehicle group SVR decreased to 83 ± 5% of the baseline. Using intravital microscopy analysis of microvessel in the dorsal skinfold window chamber, we established that the NO donor group induced significant vasodilation compared to the vehicle group. Significance NO supplementation in an acute hemodilution with PE has beneficial effects on cardiac performance. However, the NO supplementation effects with a NO donor are dose-independent and short-lasting.

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Section: Resultsmentioning

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Exogenous intravascular nitric oxide enhances ventricular function after hemodilution with plasma expander

Chatpun

Cabrales

2012

Life Sciences

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“…Depth of anesthesia was continually verified via toe pinch, if needed, isoflurane was increased by 0.1%/vol to prevent animal discomfort. Experimental setup is presented in Figure 1 (Chatpun and Cabrales 2010). …”

Section: Methodsmentioning

confidence: 99%

Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic

Ao-Ieong

Williams

Jani

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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Hemorrhage impairs myocardial contractile function and decreases oxygen delivery. This study investigates how polymerized bovine hemoglobin (PolyHb) solutions affect cardiac function after resuscitation from hemorrhagic shock (HS). Hamsters were hemorrhaged and resuscitated with PolyHb at 8.5g/dL and 11.5 g/dL. Left ventricle (LV) function was assessed during shock and resuscitation using a miniaturize conductance catheter. PolyHb resuscitation had no beneficial effects in cardiac function; it increased cardiac afterload and systemic vascular resistance (SVR) of 46 and 116% for 8.5 and 11.5 g/dL, respectively. Study findings indicate that preclinical evaluation of cardiac function is essential to develop safe and efficacious alternatives to blood transfusion.

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The Role of Blood and Plasma Viscosity in Restoring Oxygen Delivery Capacity

Tsai

Martini

Vázquez

et al. 2013

Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

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Cardiac mechanoenergetic cost of elevated plasma viscosity after moderate hemodilution

Cited by 10 publications

References 37 publications

Exogenous intravascular nitric oxide enhances ventricular function after hemodilution with plasma expander

Exogenous intravascular nitric oxide enhances ventricular function after hemodilution with plasma expander

Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic

The Role of Blood and Plasma Viscosity in Restoring Oxygen Delivery Capacity

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