Cardiac Mass and Hypertrophic Cardiomyopathy as Aggressive Presentation of Primary Cardiac Lymphoma: A Case Report

Haran, Mehandi; Enakpene, Evbu; Lodha, Ankur

doi:10.4236/jct.2012.33026

Cited by 2 publications

(4 citation statements)

References 17 publications

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“…Furthermore, CT scans and MRIs give more significant information to confirm the location of the tumor. According to previous studies, echocardiography may be a good non-invasive diagnostic tool to demonstrate the tumor [4][5][6][7]. In this study, left atrial enlargement, was found in the patient, as well as normal lung, and no metastasis feature in other parts of the body.…”

Section: Discussionsupporting

confidence: 62%

“…PCL is a rare but highly aggressive lymphoma, and it is mostly located in the heart/pericardium of men in their 50s [2][3][4][5][6][7]. Clinical manifestation generally occurs acutely and frequently undetected.…”

Section: Discussionmentioning

confidence: 99%

“…PCL contributes about 1.3-2% of all cardiac tumors and only 0.5% of all extranodal lymphomas. It is a very rare tumor based on the data from the Armed Forces Institute of Pathology (AFIP) which reported only 38 cases from 1945 to 1994 [2,[4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Definite diagnosis can be established by pathology examination, such as cytology, histopathology, and immunohistochemistry. According to previous studies, histopathological examination reveals more than 80 % diffuse large B-cell lymphoma (DLBCL), and the rest are T-cell lymphomas [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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An Assessment of Primary Cardiac Lymphoma: A Rare Case in Indonesia

Hanum,

Hardjolukito,

Tanurahardja

et al. 2023

Indonesian Journal of Cancer

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Introduction: : Primary cardiac lymphoma (PCL) is an uncommon malignancy with a high mortality rate. The disease is commonly found as non-Hodgkin’s lymphoma (NHL), mainly located in the heart or pericardium. PCL is difficult to diagnose due to its unspecific clinical manifestations. Echocardiography, computed tomography (CT) scanning, and magnetic resonance imaging (MRI) can help in diagnosing PCL, but histopathological examination is the gold standard for a definitive diagnosis. Therefore, this study aimed to compare the case of malignant cardiac lymphoma and MRI with earlier related literature. Case Presentation: This study reported a case of PCL in 52 years old male who came to Cipto Mangunkusumo Hospital with intra cardiac tumour and underwent surgery with median sternotomy. CT scan of the chest showed a mass in the left atrial and no significant abnormalities in other organs. Histopathological examination showed the morphologic feature of diffuse monotonous proliferation of atypical large B lymphocytes. The lymphoma diagnosis was supported by immunohistochemistry including CD20, MUM1, and Ki67 positivity. Conclusions: PCL was difficult to diagnose due to nonspecific clinical manifestations. Immunostaining helped to diagnose more specifically and determine the treatment plan. Histologic finding from PCL was mostly Diffuse Large B-cell lymphoma (DLBCL) and the prognosis was poor. Therefore, identifying the subtype of DLBCL was important for prognostic.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An Assessment of Primary Cardiac Lymphoma: A Rare Case in Indonesia

Hanum,

Hardjolukito,

Tanurahardja

et al. 2023

Indonesian Journal of Cancer

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ctPath: Demixing pathway crosstalk effect from transcriptomics data for differential pathway identification

Xie

Gan

Yang

et al. 2017

Journal of Biomedical Informatics

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Identifying differentially expressed pathways (DEPs) plays important roles in understanding tumor etiology and promoting clinical treatment of cancer or other diseases. By assuming gene expression to be a sparse non-negative linear combination of hidden pathway signals, we propose a pathway crosstalk-based transcriptomics data analysis method (ctPath) for identifying differentially expressed pathways. Biologically, pathways of different functions work in concert at the systematic level. The proposed method interrogates the crosstalks between pathways and discovers hidden pathway signals by mapping high-dimensional transcriptomics data into a low-dimensional pathway space. The resulted pathway signals reflect the activity level of pathways after removing pathway crosstalk effect and allow a robust identification of DEPs from inherently complex and noisy transcriptomics data. CtPath can also correct incomplete and inaccurate pathway annotations which frequently occur in public repositories. Experimental results on both simulation data and real-world cancer data demonstrate the superior performance of ctPath over other popular approaches. R code for ctPath is available for non-commercial use at the URL http://micblab.iim.ac.cn/Download/.

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Cardiac Mass and Hypertrophic Cardiomyopathy as Aggressive Presentation of Primary Cardiac Lymphoma: A Case Report

Cited by 2 publications

References 17 publications

An Assessment of Primary Cardiac Lymphoma: A Rare Case in Indonesia

An Assessment of Primary Cardiac Lymphoma: A Rare Case in Indonesia

ctPath: Demixing pathway crosstalk effect from transcriptomics data for differential pathway identification

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