Cardiac manifestations of Familial Mediterranean fever

Alsarah, Ahmad; Alsara, Osama; Laird-Fick, Heather

doi:10.4103/ajm.ajm_78_17

Cited by 33 publications

(21 citation statements)

References 38 publications

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“…[30][31][32] The ongoing inflammation and amyloidosis were shown to be related to pericarditis, valvular diseases, coronary artery disease, cardiomyopathies, subclinical atherosclerosis, and pulmonary hypertension. 33 Therefore, FMF may also affect choroid and retinal vessels. In this study, we did not evaluate choriocapillaris; however, deep inferior and inferior-hemi vascular density was significantly lower than the control group.…”

Section: Discussionmentioning

confidence: 99%

Comparison of optical coherence tomography angiography results of adult patients with Familial Mediterranean fever and healthy individuals

et al. 2019

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Purpose:The aim of this study is to assess the macular ultrastructure measuring by optical coherence tomography angiography in adult patients with Familial Mediterranean fever.Methods:Participants were 62 Familial Mediterranean fever patients and 54 healthy individuals in control group with similar age and sex. The superficial and deep vascular plexus structures covering the central fovea in an area of 6 mm × 6 mm were measured using AngioVue images taken with optical coherence tomography angiography. Vasculature structure, foveal avascular zone, acircularity index of foveal avascular zone (the ratio of the perimeter of foveal avascular zone and the perimeter of a circle with the equal area), and superficial and deep retinal plexus densities were measured.Results:The inferior deep vascular density was measured: 49.17% ± 8.59% in Familial Mediterranean fever patients, 55.56% ± 5.92% in the control group. The deep inferior-hemi vascular density was measured: 48.59% ± 10.34% in Familial Mediterranean fever patients, 56.54% ± 8.05% in the control group. Deep inferior and deep inferior-hemi vascular density was significantly reduced in Familial Mediterranean fever patients compared with healthy controls (p = 0.04 and p = 0.03, respectively).Conclusion:The vascular abnormalities in optical coherence tomography angiography show subclinical signs of microangiopathy in Familial Mediterranean fever patients. This observation, which can be obtained only through optical coherence tomography angiography, may be an ocular hallmark for Familial Mediterranean fever disease.

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Section: Discussionmentioning

confidence: 99%

Comparison of optical coherence tomography angiography results of adult patients with Familial Mediterranean fever and healthy individuals

et al. 2019

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“…Chronic subclinical inflammation has been reported to be associated with the development of coronary artery disease. 1 Impairment of both right and left ventricle functions can be observed in patients with FMF. Additionally, pericarditis, rhythm disorders, and atherosclerosis may occur, and aortic elasticity may change in patients with FMF.…”

Section: Introductionmentioning

confidence: 99%

The relation of novel cardiovascular risk parameters in patients with familial Mediterranean fever

Kozan

Ozan

Demir

et al. 2019

JRSM Cardiovascular Disease

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ObjectiveIn this study, we aimed at correlating the thickness of epicardial adipose tissue and levels of Vitamin D with cardiac risk in patients with familial Mediterranean fever.MethodsSixty-five patients with familial Mediterranean fever and 38 healthy controls with matching age and sex were included in the study. The patients with a history of familial Mediterranean fever attacks within the previous two weeks or with any history of inflammatory or cardiovascular disease were excluded. Data regarding age, gender, weight, height, waist circumference, body mass index (calculated as weight/height2), pulse wave velocity, serum Vitamin D levels from fasting blood samples, and Homeostatic Model Assessment for insulin resistance were obtained for the patients and controls. The epicardial adipose tissue was visualized as an echo-free space between the outer surface of myocardium and visceral pericardium using two-dimensional echocardiography, and the thickness of epicardial adipose tissue was measured in parasternal long-axis view at the end of diastole.ResultsThe patients with familial Mediterranean fever had significantly higher levels of C-reactive protein, epicardial adipose tissue, and pulse wave velocity (p < 0.001, <0.05, <0.005, respectively) as compared with the control group. However, the serum Vitamin D levels in the two groups were observed to be similar (p = 0.486). Weak but significant positive correlations were observed between epicardial adipose tissue thickness and C-reactive protein (r = 0.302, p < 0.005), epicardial adipose tissue thickness and pulse wave velocity (r = 0.263, p < 0.01), and C-reactive protein and pulse wave velocity (r = 0.235, p < 0.05).ConclusionThickness of epicardial adipose tissue and pulse wave velocity were observed to increase in patients with familial Mediterranean fever.

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“…This involved pulmonary hypertension, valve disorders, cardiomyopathies, pericarditis, coronary heart disease and subclinical atherosclerosis. However, the effects in children were also not specified in their review [23]. However, there are few research exploring the impact to children.…”

Section: Discussionmentioning

confidence: 99%

Ailevi Akdeniz Ateşi tanılı çocuklarda gecikmiş atrial ileti zamanı

Battal

Binnetoğlu

Aylanç

et al. 2021

Family Practice and Palliative Care

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Introduction: Familial Mediterranean Fever (FMF) is a disease with recurrent fever, characterized by painful, noninfectious inflammation of the serous membranes. It mostly affects Armenians, Turks, Arabs and Jews. Prolonged inflammation in FMF may lead to atrial fibrosis which can cause the deterioration of atrial conduction time and refractory periods of atrial myocardium.In the present study we aimed to assess atrial conduction time in children with FMF. Methods: The study included 36, children diagnosed with FMF(17 males/19 females, 13 (7-15) years) and 20 control(7 males/13 females, 11 (9-16) years) cases in our Pediatric Outpatient Clinic between October 2015 and October 2016. Tissue Doppler Echocardiography (TDE) measurements of intra-and interatrial electromechanical delay were done. P wave dispersion (Pdisp) was calculated from the 12-lead electrocardiogram. Results: Inter-atrial (Lateral PA-Tricuspid PA) and Intra-left (Lateral PA-Septal PA) atrial electromechanical delay were significantly longer in FMF patients (P<0.001,respectively). (PA: the time range between the beginning of the P wave in the surface electrocardiogram and the beginning of the tissue Doppler late diastolic wave A). Also, P-wave dispersion (Pdisp) were significantly higher in FMF patients ( p= 0.002). Conclusions: This study shows that atrial electromechanical delay and Pdisp are prolonged in children with FMF. We recommend that atrial conduction time be measured for children diagnosed with FMF.

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Cardiac manifestations of Familial Mediterranean fever

Cited by 33 publications

References 38 publications

Comparison of optical coherence tomography angiography results of adult patients with Familial Mediterranean fever and healthy individuals

Comparison of optical coherence tomography angiography results of adult patients with Familial Mediterranean fever and healthy individuals

The relation of novel cardiovascular risk parameters in patients with familial Mediterranean fever

Ailevi Akdeniz Ateşi tanılı çocuklarda gecikmiş atrial ileti zamanı

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