Cardiac magnetic resonance-tissue tracking for the early prediction of adverse left ventricular remodeling after ST-segment elevation myocardial infarction

Jae, Min; Lee, Jeong Hyun; Jung, Hye Na; Kim, Yiseul; Choe, Yeon Hyeon; Kim, Sung Mok

doi:10.1007/s10554-019-01659-w

Cited by 21 publications

(13 citation statements)

References 37 publications

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“…Classical cardiac markers, such as troponin-T and creatine kinase, were increased in all patients suffering from STEMI at admission, confirming the severity of the infarcts. We also found that creatine kinase, but not troponin T, was significantly higher in patients who developed LVAR compared with those without LVAR, consistent with a larger infarct size, which is in agreement with other studies [37,38].…”

Section: Discussionsupporting

confidence: 93%

Circulating miR-320a as a Predictive Biomarker for Left Ventricular Remodelling in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention

Galeano-Otero

Guisado

Díaz

et al. 2020

JCM

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Restoration of epicardial coronary blood flow, achieved by early reperfusion with primary percutaneous coronary intervention (PPCI), is the guideline recommended to treat patients with ST-segment-elevation myocardial infarction (STEMI). However, despite successful blood restoration, increasing numbers of patients develop left ventricular adverse remodelling (LVAR) and heart failure. Therefore, reliable prognostic biomarkers for LVAR in STEMI are urgently needed. Our aim was to investigate the role of circulating microRNAs (miRNAs) and their association with LVAR in STEMI patients following the PPCI procedure. We analysed the expression of circulating miRNAs in blood samples of 56 patients collected at admission and after revascularization (at 3, 6, 12 and 24 h). The associations between miRNAs and left ventricular end diastolic volumes at 6 months were estimated to detect LVAR. miRNAs were also analysed in samples isolated from peripheral blood mononuclear cells (PBMCs) and human myocardium of failing hearts. Kinetic analysis of miRNAs showed a fast time-dependent increase in miR-133a, miR-133b, miR-193b, miR-499, and miR-320a in STEMI patients compared to controls. Moreover, the expression of miR-29a, miR-29b, miR-324, miR-208, miR-423, miR-522, and miR-545 was differentially expressed even before PPCI in STEMI. Furthermore, the increase in circulating miR-320a and the decrease in its expression in PBMCs were significantly associated with LVAR and correlated with the expression of miR-320a in human failing myocardium from ischaemic origin. In conclusion, we determined the time course expression of new circulating miRNAs in patients with STEMI treated with PPCI and we showed that miR-320a was positively associated with LVAR.

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Section: Discussionsupporting

confidence: 93%

Circulating miR-320a as a Predictive Biomarker for Left Ventricular Remodelling in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention

Galeano-Otero

Guisado

Díaz

et al. 2020

JCM

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“…In particular, we demonstrated that cut-offs of −11.09% for GCS and −10.21 for GLS, measured at baseline CMR, are highly specific in predicting LV adverse remodeling whereas those parameters do not differ between patients with null and reverse remodeling. Although both strain CMR parameters have been used previously to predict adverse LV remodeling ( 11 , 12 , 21 ), they have never been applied to these new categories ( 7 ). Furthermore, we retrospectively evaluated the effect of ASA dose before pPCI in STEMI patients for the first time, and described a positive effect of a loading dose of 500 mg on early LV remodeling.…”

Section: Discussionmentioning

confidence: 99%

“…Myocardial salvage was quantified by the difference between AAR and IS ( 18 , 19 ). Feature tracking (CMR-FT) analysis was performed offline using dedicated commercial software (cvi42 v. 5.3, Circle Cardiovascular Imaging, Calgary, AB, Canada) as detailed elsewhere ( 11 ). CMR-FT analysis was applied using basal, mid, and apical ventricular short-axis, vertical-, and horizontal long-axis views in cine-SSFP images.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, different factors assessed by CMR within the first week of an acute STEMI, such as LVEF, IS, and microvascular obstruction (MVO), have been reported to be independent strong predictors of LV adverse remodeling and clinical outcomes after STEMI ( 9 , 10 ). The quantitative assessment of myocardial contractile deformation enabled by CMR feature tracking analysis (CMR-FT) offers deeper information on regional and global LV function other than LVEF, helping to predict LV remodeling ( 11 , 12 ). Furthermore, CMR-FT has been increasingly used in STEMI patients to assess the efficacy of cardioprotective therapies in preventing post-infarction LV remodeling ( 12 – 14 ), such as to evaluate the effect of intravenous administration of metoprolol on long term prognostic effect in the randomized METOCARD-CNIC trial ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

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Protective Value of Aspirin Loading Dose on Left Ventricular Remodeling After ST-Elevation Myocardial Infarction

Calvieri

Galea

Cilia

et al. 2022

Front. Cardiovasc. Med.

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AimsLeft ventricular (LV) remodeling after ST-elevation myocardial infarction (STEMI) is a complex process, defined as changes of LV volumes over time. CMR feature tracking analysis (CMR-FT) offers an accurate quantitative assessment of LV wall deformation and myocardial contractile function. This study aimed to evaluate the role of myocardial strain parameters in predicting LV remodeling and to investigate the effect of Aspirin (ASA) dose before primary coronary angioplasty (pPCI) on myocardial injury and early LV remodeling.Methods and ResultsSeventy-eight patients undergoing CMR, within 9 days from symptom onset and after 6 months, were enrolled in this cohort retrospective study. We divided the study population into three groups based on a revised Bullock's classification and we evaluated the role of baseline CMR features in predicting early LV remodeling. Regarding CMR strain analysis, worse global circumferential and longitudinal strain (GCS and GLS) values were associated with adverse LV remodeling. Patients were also divided based on pre-pPCI ASA dosage. Significant differences were detected in patients receiving ASA 500 mg dose before pPCI, which showed lower infarct size extent and better strain values compared to those treated with ASA 250 mg. The stepwise multivariate logistic regression analysis, adjusted for covariates, indicated that a 500 mg ASA dose remained an inverse independent predictor of early adverse LV remodeling.ConclusionGCS and GLS have high specificity to detect early LV adverse remodeling. We first reported a protective effect of ASA loading dose of 500 mg before pPCI on LV myocardial damage and in reducing early LV adverse remodeling.

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“…Peak GLS, GCS and global radial strain were found to be independently positively associated with age and negatively associated with body mass index in healthy adults [52]. Cha et al found that GLS may aid in the erly prediction of adverse left ventricular (LV) remodeling after reperfusion following STEMI [53]. In other work, no significant difference in strain was found for patients with acute myocarditis and preserved ejection fraction (EF) and controls [54].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 98%

Cardiovascular imaging 2019 in the International Journal of Cardiovascular Imaging

Reiber

Pereira

Dallan

et al. 2020

Int J Cardiovasc Imaging

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Cardiac magnetic resonance-tissue tracking for the early prediction of adverse left ventricular remodeling after ST-segment elevation myocardial infarction

Cited by 21 publications

References 37 publications

Circulating miR-320a as a Predictive Biomarker for Left Ventricular Remodelling in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention

Circulating miR-320a as a Predictive Biomarker for Left Ventricular Remodelling in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention

Protective Value of Aspirin Loading Dose on Left Ventricular Remodeling After ST-Elevation Myocardial Infarction

Cardiovascular imaging 2019 in the International Journal of Cardiovascular Imaging

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