Cardiac magnetic resonance in acute rheumatic fever

Sepulveda, Diana Lamprea; Calado, Eveline Barros; Albuquerque, Eugenio Soares de; Rodrigues, Alfredo José; Siqueira, Maria Eduarda Menezes de; Lapa, C; Saraiva, Lurildo R.; Mochiduky, R I; Sobral, Dário; Uellendahl, Marly

doi:10.1186/1532-429x-15-s1-o23

Journal of Cardiovascular Magnetic Resonance

2013

DOI: 10.1186/1532-429x-15-s1-o23

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Cardiac magnetic resonance in acute rheumatic fever

Diana Lamprea Sepulveda

Eveline Barros Calado

Eugenio Soares de Albuquerque³

et al.

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“…7 – 9 Sepulveda et al reported diffuse, mesocardial and heterogenous enhancement of the myocardium in acute rheumatic fever using LGE. 10 The possible resultant fibrosis may therefore be studied by LGE and have prognostic value similar to that in degenerative MR. Furthermore, data concerning biomarkers of collagen degradation and formation in MR are limited and mostly comprise animal studies in degenerative MR. 11 , 12 …”

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confidence: 99%

Assessment of myocardial fibrosis by late gadolinium enhancement imaging and biomarkers of collagen metabolism in chronic rheumatic mitral regurgitation

Meel

Nethononda

Libhaber

et al. 2018

CVJA

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SummaryBackgroundIn chronic rheumatic mitral regurgitation (CRMR), involvement of the myocardium in the rheumatic process has been controversial. Therefore, we sought to study the presence of fibrosis using late gadolinium enhancement cardiac magnetic resonance imaging (LGE–CMR) and biomarkers of collagen turnover in CRMR. MethodsTwenty–two patients with CRMR underwent CMR and echocardiography. Serum concentrations of matrix metalloproteinase– 1 (MMP–1), tissue inhibitor of MMP–1 (TIMP– 1), MMP–1–to–TIMP–1 ratio, procollagen III N–terminal pro–peptide (PIIINP) and procollagen type IC peptide (PIP) were measured. ResultsFour patients had fibrosis on LGE–CMR. PIP and PIIINP concentrations were similar to those of the controls, however MMP–1 concentration was increased compared to that of the controls (log MMP–1 3.5 ± 0.7 vs 2.7 ± 0.9, p = 0.02). There was increased MMP–1 activity as the MMP–1–to– TIMP–1 ratio was higher in CRMR patients compared to the controls (–1.2 ± 0.6 vs –2.1 ± 0.89, p = 0.002). ConclusionMyocardial fibrosis was rare in CRMR patients. CRMR is likely a disease characterised by the predominance of collagen degradation rather than increased synthesis and myocardial fibrosis.

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confidence: 99%

Assessment of myocardial fibrosis by late gadolinium enhancement imaging and biomarkers of collagen metabolism in chronic rheumatic mitral regurgitation

Meel

Nethononda

Libhaber

et al. 2018

CVJA

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Cardiac magnetic resonance in acute rheumatic fever

Cited by 1 publication

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Assessment of myocardial fibrosis by late gadolinium enhancement imaging and biomarkers of collagen metabolism in chronic rheumatic mitral regurgitation

Assessment of myocardial fibrosis by late gadolinium enhancement imaging and biomarkers of collagen metabolism in chronic rheumatic mitral regurgitation

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