Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy

Al’Aref, Subhi J.; Altibi, Ahmed; Malkawi, Abdallah; Mansour, Munthir; Baskaran, Lohendran; Masri, Ahmad; Rahmouni, Hind; Abete, Raffaele; Andreini, Daniele; Aquaro, Giovanni Donato; Barison, Andrea; Bogaert, Jan; Camastra, Giovanni; Carigi, Samuela; Carrabba, Nazario; Casavecchia, Grazia; Censi, Stefano; Cicala, Gloria; Conte, Edoardo; Cecco, Carlo N. De; Lazzari, Manuel De; Giovine, Gabriella Di; Roma, Mauro Di; Dobrovie, Monica; Focardi, Marta; Gaibazzi, Nicola; Gismondi, Annalaura; Gravina, Matteo; Guglielmo, Marco; Lanzillo, Chiara; Lombardi, Massimo; Lorenzoni, Valentina; Lozano-Torres, Jordi; Margonato, Davide; Martini, Chiara; Marzo, Francesca; Masci, Pier Giorgio; Masi, Ambra; Méméo, Riccardo; Moro, Claudio; Mushtaq, Saima; Nese, Alberto; Palumbo, Alessandro; Pavon, Anna Giulia; Pedrotti, Patrizia; Pepi, Mauro; Marra, Martina Perazzolo; Pica, Silvia; Pradella, Silvia; Presicci, Cristina; Rabbat, Mark; Raineri, Claudia; Rodríguez-Palomares, José F.; Sbarbati, Stefano; Schoepf, U. Joseph; Squeri, Angelo; Sverzellati, Nicola; Symons, Rolf; Tat, Emily; Timpani, Mauro; Todiere, Giancarlo; Valentini, Adele; Varga-Szemes, Ákos; Volpe, Alessandra; Fusini, Laura; Guaricci, Andrea Igoren; Schwitter, Jürg

doi:10.1093/ehjci/jeac124

Cited by 8 publications

(4 citation statements)

References 33 publications

(43 reference statements)

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“…Presence and extension of fibro-fatty myocardial replacement (ARVC pathologic hallmark) can be detect using LGE imaging and is found in up to 88% of patients, with a diagnostic accuracy of 98% when wall motion alterations and pre-/post-contrast signal abnormalities were considered together [78][79][80], although LGE can be detected in other conditions (e.g., sarcoidosis, rheumatic disease, myocarditis) and its interpretation can be difficult due to RV limited thickness [81].…”

Section: Arrhythmogenic Right Ventricular Cardiomyopathymentioning

confidence: 99%

The Role of Magnetic Resonance Imaging in Cardiomyopathies in the Light of New Guidelines: A Focus on Tissue Mapping

Forleo,

Carella,

Basile

et al. 2024

Preprint

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Cardiomyopathies (CMPs) are a group of myocardial disorders that are characterized by structural and functional abnormalities of the heart muscle. These abnormalities occur in the absence of coronary artery disease (CAD), hypertension, valvular disease, and congenital heart disease. CMPs are an increasingly important topic in the field of cardiovascular diseases due to the complexity of their diagnosis and management. In 2023, the ESC guidelines on cardiomyopathies were first published, marking significant progress in the field. The growth of techniques such as cardiac magnetic resonance imaging (CMR) and genetics has been fueled by the development of multimodal imaging approaches. For the diagnosis of CMPs, a multimodal imaging approach, including CMR, is recommended. CMR has become the standard for non-invasive analysis of cardiac morphology and myocardial function. This document provides an overview of the role of CMR in CMPs, with a focus on tissue mapping. CMR enables the characterization of myocardial tissues and the assessment of cardiac functions. CMR sequences and techniques, such as late gadolinium enhancement (LGE) and parametric mapping, provide detailed information on tissue composition, fibrosis, edema, and myocardial perfusion. These techniques offer valuable insights for early diagnosis, prognostic evaluation, and therapeutic guidance of CMPs. The use of quantitative CMR markers enables personalized treatment plans, improving overall patient outcomes. This review aims to serve as a guide for the use of these new tools in clinical practice.

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Section: Arrhythmogenic Right Ventricular Cardiomyopathymentioning

confidence: 99%

The Role of Magnetic Resonance Imaging in Cardiomyopathies in the Light of New Guidelines: A Focus on Tissue Mapping

Forleo,

Carella,

Basile

et al. 2024

Preprint

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“…Echocardiography is also useful to estimate the volume status, trying to early identify patients with venous congestion and fluid overload through typical echocardiographic signs: right ventricular function calculated through some parameters such as the Fractional Area Change (FAC), the Tricuspid Annular Plane Systolic Excursion (TAPSE) and peak systolic velocity on Tissue Doppler (S′ wave) [54], tricuspid regurgitation [55], and inferior vena cava congestion [56] (Figure 2) and some haemodynamic parameters (esteem of central venous pressure, systolic pressure), lateral and septal longitudinal movement of the wall (E′), the mitral the inflow velocity (E) and their ratio E/E′, are parameters that relate to pulmonary capillary wedge pressure, (E/E′ >15 correspond approximately to >18 mmHg) [57,58]. Cardiac magnetic resonance (CMR) allows the morpho-functional study in patient with poor acoustic window or allows to evaluate the state of myocardial fibrosis and inflammation, useful for clarifying the progress of HF and assists echocardiography in identification the cause of HF [59][60][61].…”

Section: Imaging Modalitiesmentioning

confidence: 99%

Assessment and management of Heart Failure in Patients with Chronic Kidney Disease

Guaricci¹,

Sturdà²,

Russo³

et al. 2023

Preprint

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CKD in HF patients is very common condition, their dysfunction is closely linked and influence each other, so their management required multidisciplinary and personalized approaches. The diagnosis of HF and CDK relies on signs and symptoms. Several tools, such as blood-based biomarkers and echography help us to clarify and discriminate the main characteristics of these patients. Evidence in improving survival due to new drug-employment in HF, has increasingly challenged physicians to manage patients with multiple diseases, especially in patients with CKD. The difficulty is in the safe administration of these drugs in patients with HF and CKD. Knowing up to which values of creatinine or renal clearance any drug can be administered is fundamental. We wanted to summarize, on this sizable and complex topic, the experiences of various prior study to get clearer ideas and a more precise reference about the assessment and management of HF and CKD.

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“…19 Moreover, right ventricular (RV) systolic dysfunction on CMR is an important predictor of allcause mortality or cardiac transplantation. 20,21 DCM is also characterized by microvascular dysfunction, whose severity is associated with the degree of LV impairment: in a recent study on 65 DCM patients studied with quantitative perfusion mapping CMR, absolute rest perfusion was slightly more elevated in DCM than controls; during adenosine vasodilation, on the other hand, absolute stress perfusion and myocardial perfusion reserve were both reduced compared with controls. 22 Myocardial perfusion was further decreased in patients with severe LV systolic dysfunction, and in LV segments affected by myocardial fibrosis.…”

Section: Dilated Cardiomyopathymentioning

confidence: 99%

Acute clinical presentation of nonischemic cardiomyopathies: early detection by cardiovascular magnetic resonance

Todiere

Barison

Baritussio

et al. 2022

Journal of Cardiovascular Medicine

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Nonischemic cardiomyopathies include a wide range of dilated, hypertrophic and arrhythmogenic heart muscle disorders, not explained by coronary artery disease, hypertension, valvular or congenital heart disease. Advances in medical treatments and the availability of implantable cardioverter defibrillators to prevent sudden cardiac death have allowed a substantial increase in the survival of affected individuals, thus making early diagnosis and tailored treatment mandatory. The characterization of cardiomyopathies has received a great boost from the recent advances in cardiovascular magnetic resonance (CMR) imaging, which, to date, represents the gold standard for noninvasive assessment of cardiac morphology, function and myocardial tissue changes.An acute clinical presentation has been reported in a nonnegligible proportion of patients with nonischemic cardiomyopathies, usually complaining of acute chest pain, worsening dyspnoea or palpitations; ‘hot phases’ of cardiomyopathies are characterized by a dynamic rise in high-sensitivity troponin, myocardial oedema on CMR, arrhythmic instability, and by an increased long-term risk of adverse remodelling, progression of myocardial fibrosis, heart failure and malignant ventricular arrhythmias. Prompt recognition of ‘hot phases’ of nonischemic cardiomyopathies is of utmost importance to start an early, individualized treatment in these high-risk patients. On the one hand, CMR represents the gold standard imaging technique to detect early and typical signs of ongoing myocardial remodelling in patients presenting with a ‘hot phase’ nonischemic cardiomyopathy, including myocardial oedema, perfusion abnormalities and pathological mapping values. On the other hand, CMR allows the differential diagnosis of other acute heart conditions, such as acute coronary syndromes, takotsubo syndrome, myocarditis, pericarditis and sarcoidosis. This review provides a deep overview of standard and novel CMR techniques to detect ‘hot phases’ of cardiomyopathies, as well as their clinical and prognostic utility.

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Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy

Cited by 8 publications

References 33 publications

The Role of Magnetic Resonance Imaging in Cardiomyopathies in the Light of New Guidelines: A Focus on Tissue Mapping

The Role of Magnetic Resonance Imaging in Cardiomyopathies in the Light of New Guidelines: A Focus on Tissue Mapping

Assessment and management of Heart Failure in Patients with Chronic Kidney Disease

Acute clinical presentation of nonischemic cardiomyopathies: early detection by cardiovascular magnetic resonance

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