Cardiac iron overload evaluation in thalassaemic patients using T2* magnetic resonance imaging following chelation therapy: a multicentre cross-sectional study

Chapchap, Eduardo Cerello; Silva, Murilo Marques Almeida; Assis, Reijane Alves de; Kerbauy, Lucila Nassif; Diniz, Michelli da Silva; Rosemberg, Laércio Alberto; Loggetto, Sandra Regina; Araújo, Aderson da Silva; Fabron, Antonio; Veríssimo, Mônica Pinheiro de Almeida; Baldanzi, Giorgio Roberto; Espósito, Breno Pannia; Tricta, Fernando; Steagall, Merula Emmanoel Anargyrou; Vellozo, Claudia Ângela Galleni Di Sessa; Fertrin, Kleber Yotsumoto; Baroni, Ronaldo Hueb; Hamerschlak, Nelson

doi:10.1016/j.htct.2021.01.014

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Long-term followup imaging with T2* has improved the prognosis in thalassemia patients. [22][23][24][25] In the current study, emphasizing the importance of cardiac dysfunction in TDT patients, we mainly aimed to investigate the association between left and right ventricular (LV and RV) function measured by cardiac MRI and iron deposition estimation by CMR T2* in a sample of Iranian TDT patients.…”

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confidence: 99%

The relationship of myocardial and liver T2* values with cardiac function and laboratory findings in transfusion-dependent thalassemia major patients: A retrospective cardiac MRI study

Abdi

Taheri

Haghighi

et al. 2023

J Cardiovasc Thorac Res

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Introduction: Cardiac complications are the leading cause of death in thalassemia patients. It is assumed that progressive iron accumulation results in myocyte damage. Myocardial T2* measurement by cardiac MRI quantifies iron overload. We aimed to study the association between left and right ventricular (LV and RV) function and iron deposition estimation by cardiac MRI T2* in a sample of Iranian patients. Methods: Cardiac MRI exams of 118 transfusion-dependent thalassemia major patients were evaluated retrospectively. Biventricular function and volume and myocardial and liver T2* values were measured. The demographic and lab data were registered. Poisson and chi-square regression analyses investigated the correlation between the T2* value and ventricular dysfunction. Results: The study participants’ mean (SD) age was 32.7y (9.02), and 47.46% were female. Forty-nine cases (41.52%) revealed at least uni-ventricular dysfunction. LV dysfunction was noted in 20 cases, whereas 47 patients revealed RV dysfunction. The risk of LV dysfunction was 5.3-fold higher in patients with cardiac T2* value less than 10msec (RR=5.3, 95% CI=1.6, 17.1, P<0.05). No association was found between age, liver T2* value, serum ferritin level, and chelation therapy with the risk of LV and RV dysfunction. Conclusion: Cardiac MRI T2* measure is a good indicator of LV dysfunction. Moreover, MRI parameters, especially RV functional measures, may have a substantial role in patient management. Therefore, cardiac MRI should be included in beta-thalassemia patients’ management strategies.

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Section: Introductionmentioning

confidence: 99%

The relationship of myocardial and liver T2* values with cardiac function and laboratory findings in transfusion-dependent thalassemia major patients: A retrospective cardiac MRI study

Abdi

Taheri

Haghighi

et al. 2023

J Cardiovasc Thorac Res

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Assessment of iron status

Von Holle

2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review Iron is an essential trace element in human health that can be harmful at abnormal levels such as iron overload or deficiency. Measured iron status in the body can depend on health outcomes experienced by the individual and this can complicate its accurate assessment. This review will highlight recent research on iron assessment in the literature. Recent findings Research on iron assessment within the past 18 months included some common themes spanning new methods and biomarkers, as well as existing problems in assessing iron deficiency and overload. Heterogeneity in associations between inflammation and iron levels are reflected across different inflammatory biomarkers. New methods relevant to low- and high-resource settings may improve assessment in tissues with iron deficiency and overload. Consensus papers outlined best practices when using MRI to assess iron status. Outside of newer methods, traditional serum markers are the subject of a call for updated guidance when assessing iron status. Summary Research continues on the topic of iron assessment, underlying its complex metabolism in the body and resulting challenges in assessment. Current literature underscores progress to make iron assessment more accessible, improve existing methods, and update current assessment methods so they correspond with recent research to improve human health.

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Application of magnetic resonance quantitative technique to calculate liver iron concentration in the diagnosis and efficacy evaluation of transfusion-related iron overload

Niu,

Xia,

Zhu

et al. 2023

Int J Radiat Res

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Cardiac iron overload evaluation in thalassaemic patients using T2* magnetic resonance imaging following chelation therapy: a multicentre cross-sectional study

Cited by 3 publications

References 27 publications

The relationship of myocardial and liver T2* values with cardiac function and laboratory findings in transfusion-dependent thalassemia major patients: A retrospective cardiac MRI study

The relationship of myocardial and liver T2* values with cardiac function and laboratory findings in transfusion-dependent thalassemia major patients: A retrospective cardiac MRI study

Assessment of iron status

Application of magnetic resonance quantitative technique to calculate liver iron concentration in the diagnosis and efficacy evaluation of transfusion-related iron overload

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