Cardiac Iodine-123 Metaiodobenzylguanidine Imaging Predicts Sudden Cardiac Death Independently of Left Ventricular Ejection Fraction in Patients With Chronic Heart Failure and Left Ventricular Systolic Dysfunction

Tamaki, Shunsuke; Yamada, Takahisa; Okuyama, Yuji; Morita, Takashi; Shoji, Shuichi; Tsukamoto, Yasumasa; Masuda, Masaharu; Okuda, K; Iwasaki, Yusuke; Yasui, Toshihiro; Hori, Masatsugu; Fukunami, Masatake

doi:10.1016/j.jacc.2008.10.025

Cited by 213 publications

(147 citation statements)

References 31 publications

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“…Merlet et al reported that lower 123 I-MIBG H/M values was an important index for predicting poor prognoses in HF patients with ischemic or idiopathic cardiomyopathy [10]. Tamaki et al showed that cardiac MIBG imaging predicts sudden cardiac death independently of LVEF in patients with chronic HF [26]. Thus, our findings are corroborated by previous reports.…”

Section: G Kaplan-meier Survival Analysissupporting

confidence: 90%

Association of Iodine-123 BMIPP and MIBG Cardiac Uptakes with Left Ventricular Functional Parameters Assessed by Gated Myocardial Perfusion SPECT

Nakae

Mitsunami²,

Hayashi³

et al. 2013

PHF

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Abstract-We investigated how the degree of cardiac uptakes of radioactive fatty acid (FA) analog ( 123 I-BMIPP) or norepinephrine (NE) analog (123 I-MIBG) was related to left ventricular (LV) functional parameters in patients with heart disease, which might be a predictor of cardiac events.Patients with ejection fraction (EF) of 16.2%-82.2% underwent 123 I-BMIPP or 123 I-MIBG myocardial scintigraphy, and were followed up over 1177±486 days. LV systolic functional parameter EF, diastolic parameters 1/3FR (first third filling rate), PFR (peak filling rate), and TPF (time to PFR) were calculated using quantitative gated SPECT.123 I-BMIPP uptake (n=30) was significantly correlated with EF, 1/3FR, and PFR but not TPF.123 I-MIBG uptake (n=37) was also correlated with EF, 1/3FR, and PFR but not TPF. In contrast, TPF was positively correlated with age, and was significantly longer in women than in men. Such findings were also observed in normal EF patients (≥50%, n=100). Kaplan-Meier analysis showed the occurrence of earlier cardiac events in the case of patients with decreased 123 I-BMIPP and 123 I-MIBG uptake, decreased PFR, and prolonged TPF.The degree of decreased cardiac uptakes of FA and NE may be associated with the grade of systolic and diastolic dysfunctions assessed by EF, PFR, and 1/3FR. In contrast, prolonged TPF, another diastolic parameter, may rather be caused by aging and female gender, independent of EF. Despite these differences, myocardial FA metabolism impairment, cardiac sympathetic nerve inactivity, decreased PFR, and prolonged TPF may all indicate poor cardiac prognosis in patients with heart disease.

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Section: G Kaplan-meier Survival Analysissupporting

confidence: 90%

Association of Iodine-123 BMIPP and MIBG Cardiac Uptakes with Left Ventricular Functional Parameters Assessed by Gated Myocardial Perfusion SPECT

Nakae

Mitsunami²,

Hayashi³

et al. 2013

PHF

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“…Tamaki et al compared ECG parameters-HRV, QT dispersion, and SAECGwith 123 I-mIBG findings in 106 patients with LVEF \ 40%, and those with SCD had a lower H/M and higher WR, with ECG variables showing no independent relationship to outcome. 124 In ADMIRE-HF, combined arrhythmic events were more common in subjects with H/M \ 1.60 (10.4%) than in those with H/M C 1.6 (3.5%, P \ 0.01). 71 In a subanalysis of 578 patients without an ICD, Senior et al 125 reported only one fatal arrhythmic event in patients with H/M C 1.60.…”

Section: Cardiac Arrhythmiasmentioning

confidence: 90%

Cardiac autonomic imaging with SPECT tracers

Travin

2013

Journal of Nuclear Cardiology

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“…In the case of some patients the final arrhythmia is a natural result of the end-stage irreversible heart pump dysfunction; while in the case of some patients functioning quite well, sudden cardiac death (SCD) occurs. It was suggested in numerous studies that the disorders of MIBG uptake can be used as predictors of the higher risk of serious ventricular arrhythmias and SCD [43,[70][71][72][73] The reduced MIBG uptake and the corresponding degeneration of the myocardial sympathetic innervation was observed in early stages of DLB and PD by Suzuki et al, and the functions of the adrenergic system, measured with the H/M ratio, was significantly reduced in DLB patients compared to PD patients [81].…”

Section: The Study Of Merlet Et Al Published In 1992 Was the Firstmentioning

confidence: 99%

Metaiodobenzylguanidine scintigraphy of cardiac sympathetic innervation

Teresińska¹

2012

Nucl. Med. Rev.

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Metaiodobenzylguanidine (MIBG), a noradrenaline analogue, labelled with radioactive iodine I-123 is used for assessing pre-synaptic activity of the myocardial adrenergic system. The paper describes the mechanism of myocardial I-123-MIBG uptake and the relevant examination methods. It also refers to the necessity of standardising acquisition methods and assessment criteria in order to improve comparability of results, especially numerical results, originating from various countries and centres.Although first introduced as a cardiological diagnostic procedure 30 years ago, I-123-MIBG myocardial scintigraphy continues to be mostly applied as a research method, even though its diagnostic and/or prognostic importance, especially in the case of heart failure, has been widely reported. The recently published results of two extensive retrospective works and a major prospective, multi-centre international ADMIRE-HF study confirmed that I-123-MIBG scintigraphy has a high independent prognostic value in evaluating patients with heart failure. Abnormal myocardial I-123-MIBG uptake can also be indicative of higher risk of ventricular arrhythmias and sudden cardiac death in patients with heart failure. I-123-MIBG myocardial scintigraphy also seems to have considerable potential for the detection and differentiation of neurodegenerative diseases.

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Cardiac Iodine-123 Metaiodobenzylguanidine Imaging Predicts Sudden Cardiac Death Independently of Left Ventricular Ejection Fraction in Patients With Chronic Heart Failure and Left Ventricular Systolic Dysfunction

Abstract: Cardiac MIBG WR, but not SAECG, HRV, or QT dispersion, is a powerful predictor of SCD in patients with mild-to-moderate CHF, independently of LVEF.

Cited by 213 publications

References 31 publications

Association of Iodine-123 BMIPP and MIBG Cardiac Uptakes with Left Ventricular Functional Parameters Assessed by Gated Myocardial Perfusion SPECT

Association of Iodine-123 BMIPP and MIBG Cardiac Uptakes with Left Ventricular Functional Parameters Assessed by Gated Myocardial Perfusion SPECT

Cardiac autonomic imaging with SPECT tracers

Metaiodobenzylguanidine scintigraphy of cardiac sympathetic innervation

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