Cardiac involvement in the long-term implications of COVID-19

Satterfield, Benjamin A.; Bhatt, Deepak L.; Gersh, Bernard J.

doi:10.1038/s41569-021-00631-3

Cited by 102 publications

(111 citation statements)

References 103 publications

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“…In contrast to the lung, examination of distal tissues including kidney and heart showed moderate to no pathological features at 3dpi for either virus (Figure S1C-D). We observed no signs of cellular infiltration in the kidney at this time point, whereas in the heart, an organ often associated with COVID-19 complications (Satterfield et al, 2021), we noted some evidence for inflammation and leukocytic infiltrate in response to both viruses (Figure S1C-D, green stars). Together, these data suggest that the hamster phenocopies many of the histological characteristics seen in the human response to IAV or SARS-CoV-2 during acute infection.…”

Section: Resultsmentioning

confidence: 73%

SARS-CoV-2 infection results in lasting and systemic perturbations post recovery

Frere

Serafini

Pryce

et al. 2022

Preprint

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SARS-CoV-2 has been found capable of inducing prolonged pathologies collectively referred to as Long-COVID. To better understand this biology, we compared the short- and long-term systemic responses in the golden hamster following either SARS-CoV-2 or influenza A virus (IAV) infection. While SARS-CoV-2 exceeded IAV in its capacity to cause injury to the lung and kidney, the most significant changes were observed in the olfactory bulb (OB) and olfactory epithelium (OE) where inflammation was visible beyond one month post SARS-CoV-2 infection. Despite a lack of detectable virus, OB/OE demonstrated microglial and T cell activation, proinflammatory cytokine production, and interferon responses that correlated with behavioral changes. These findings could be corroborated through sequencing of individuals who recovered from COVID-19, as sustained inflammation in OB/OE tissue remained evident months beyond disease resolution. These data highlight a molecular mechanism for persistent COVID-19 symptomology and characterize a small animal model to develop future therapeutics.

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Section: Resultsmentioning

confidence: 73%

SARS-CoV-2 infection results in lasting and systemic perturbations post recovery

Frere

Serafini

Pryce

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and leads to various cardiac manifestations, including signs of myocardial injury [ 84 , 85 , 86 ]. Numerous cases have been described with clinically suspected myocarditis [ 87 , 88 , 89 ].…”

Section: Cmr In Different Forms Of Myocarditismentioning

confidence: 99%

Cardiovascular Magnetic Resonance in Myocarditis

et al. 2022

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Myocarditis is an inflammatory disease of the myocardium, and its diagnosis remains challenging owing to a varying clinical presentation and broad spectrum of underlying aetiologies. In clinical practice, cardiovascular magnetic resonance has become an invaluable non-invasive imaging tool in the evaluation of patients with clinically suspected myocarditis, mainly thanks to its unique multiparametric tissue characterization ability. Although considered as useful, the method also has its limitations. This review aims to provide an up-to-date overview of the strengths and weaknesses of cardiovascular magnetic resonance in the diagnostic work-up of patients with clinically suspected myocarditis in a broad clinical context.

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“…The World Health Organization has defined this as “post COVID-19 condition.” Common presentation includes shortness of breath, palpitation, anxiety, and depression lingering for several months after acute infection. 26 , 27 Recent data also suggests that post COVID-19 condition might not be limited to somatic symptoms, with studies showing a 7-fold increased risk of developing depression and mental health issues. 28 …”

Section: Post Covid-19 Conditionmentioning

confidence: 99%

“…Although the cause of these symptoms is not clear, one possible link that partly explains the prolonged shortness of breath experienced by some patients is COVID-19–associated myocarditis and the associated microvascular dysfunction. 26 As the pandemic continues and therapeutics improve survival from acute infection, the number of patients reporting post COVID-19 condition is predicted to grow. Several medical centers have already established clinics to better coordinate care and conduct research on the long-term impact and treatment of COVID-19.…”

Section: Post Covid-19 Conditionmentioning

confidence: 99%

The Way Ahead: Life After COVID-19

Al-Mallah

2021

Methodist DeBakey Cardiovascular Journal

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Much has changed in the 2 years since the start of the coronavirus disease 19 (COVID-19) pandemic. The need for social distancing catalyzed the digitization of healthcare delivery and medical education—from telemedicine and virtual conferences to online residency/fellowship interviews. Vaccine development, particularly in the field of mRNA technology, led to widespread availability of safe and effective vaccines. With improved survival from acute infection, the healthcare system is dealing with the ever-growing cohort of patients with lingering symptoms. In addition, social media platforms have fueled a plethora of misinformation campaigns that have adversely affected prevention and control measures. In this review, we examine how COVID-19 has reshaped the healthcare system, and gauge its potential effects on life after the pandemic.

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Cardiac involvement in the long-term implications of COVID-19

Cited by 102 publications

References 103 publications

SARS-CoV-2 infection results in lasting and systemic perturbations post recovery

SARS-CoV-2 infection results in lasting and systemic perturbations post recovery

Cardiovascular Magnetic Resonance in Myocarditis

The Way Ahead: Life After COVID-19

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