Cardiac involvement in polymyositis

Denbow, C E; Lie, J.T.; Tancredi, Robert G.; Bunch, Thomas W.

doi:10.1002/art.1780221007

Cited by 210 publications

(52 citation statements)

References 8 publications

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“…However, we believe that the clinical situation of active myositis occurring at the same time as active myocarditis, coupled with elevated levels of the MB isoenzyme of CPK and clinical evidence of myocardial dysfunction, make this association highly likely without having autopsy confirmation or these followup studies. Further, an association between myositis and myocarditis due to generalized inflammation of striated muscle has been clinically and pathologically documented in polymyositis/dermatomyositis (12)(13)(14)18) and in SLE (1 1). In view of the distinct histopathologic lesions found in the myocardium of patients with PSS and those with polymyositis (14), it is interesting to speculate that the 3 patients in our series had a combination of myocardial vascular reactivity and inflammatory infiltrate secondary to a generalized myositis which led to early and progressive cardiac dysfunction.…”

Section: (14)mentioning

confidence: 99%

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Association of myositis and myocarditis in progressive systemic sclerosis

West

Killian

Lawless

1981

Arthritis & Rheumatism

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gressive systemic sclerosis revealed a highly significant (P < 0.001) association between myositis and myocarditis. Three patients developed clinically overt myocarditis as an early feature of their disease. These patients had an idlammatory myopathy indistinguishable from polymyositis. Despite an excellent clinical response to steroids, the late occurrence of life-threatening conduction system defects appeared while they were receiving therapy. Consequently, patients with progressive systemic sclerosis and myositis should be evaluated for a coexisting myocarditis. The findings in these patients lend further support to the concept of a generalized myopathic process among the connective tissue diseases.

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Section: (14)mentioning

confidence: 99%

“…The reported prevalence of myocardial involvement in progressive systemic sclerosis (PSS) has varied widely in the literature (14). Associated renal and pulmonary disease has contributed to this confusing picture ($6).…”

mentioning

confidence: 99%

Association of myositis and myocarditis in progressive systemic sclerosis

West

Killian

Lawless

1981

Arthritis & Rheumatism

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“…Clinically manifest myocardial involvement was found in less than 15% of PM/DM patients [10], but subclinical cardiac dysfunction may be more common [11]. Dyspnoea, hypoxia, and parenchymal opacities in the chest roentgenogram because of congestive heart failure need to be distinguished from salient findings in pulmonary parenchymal or respiratory muscle disease.…”

Section: Extrinsic Lung Diseasementioning

confidence: 98%

Interstitial lung disease in polymyositis and dermatomyositis

Schnabel¹,

Hellmich²,

Gross

2005

Curr Rheumatol Rep

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Interstitial lung disease occurs in approximately one-third of patients with polymyositis and dermatomyositis (PM/DM) and has an adverse effect on survival. It is commonly a component of early PM/DM and can precede the onset of muscle or skin disease. Its most common histopathology is nonspecific interstitial pneumonia. This is a more benign pattern, with respect to response to immunosuppression and also long-term survival, than the pattern of usual interstitial pneumonia seen in idiopathic pulmonary fibrosis. The clinical course of PM/DM lung disease is heterogeneous. Progressive and nonprogressive disease needs to be distinguished by clinical and physiologic monitoring to avoid over-treatment. Patients with ongoing functional deterioration mostly benefit from immunosuppression. The experience with corticosteroid monotherapy is discouraging but cyclophosphamide, given as daily oral or intravenous pulse therapy together with corticosteroids, was found to be beneficial in many patients. Other immunosuppressants may be of benefit as well, but the weight of the current evidence supports the use of cyclophosphamide first.

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“…A mild non-erosive inflammatory arthritis involving hands, wrists and knees occurs in some cases (Schumacher et al 1979) and myocarditis and congestive cardiac failure have been described (Denbow et al 1979). …”

Section: Idiopathic Inflammatory Myopathiesmentioning

confidence: 99%