Cardiac involvement in dengue infection

Shivanthan, Mitrakrishnan Chrishan; Navinan, Mitrakrishnan Rayno; Constantine, Godwin; Rajapakse, Senaka

doi:10.3855/jidc.6200

Cited by 40 publications

(43 citation statements)

References 43 publications

(63 reference statements)

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“…Cardiac rhythm disturbances like sinus node dysfunction, atrioventricular conduction blocks, atrial fibrillation, ventricular tachycardia, and ectopic ventricular beats have been reported in dengue infection (2)(3)(4). In dengue fever, most of the cardiac complications are mild, self-limiting and are underdiagnosed (2).…”

Section: Th -8th Daymentioning

confidence: 99%

“…The spectrum of cardiac manifestations includes self-limiting arrhythmias to myocarditis causing hypotension and pulmonary edema (1,2). Various cardiac rhythm disturbances have been reported in dengue infection (2)(3)(4). Eventhough cardiac involvement is not uncommon, it can cause significant morbidity and mortality (3).…”

Section: Introductionmentioning

confidence: 99%

“…Various cardiac rhythm disturbances have been reported in dengue infection (2)(3)(4). Eventhough cardiac involvement is not uncommon, it can cause significant morbidity and mortality (3). Arrhythmias are the first and early indicators of myocarditis (4,5).…”

Section: Introductionmentioning

confidence: 99%

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Junctional Rhythm in a Child with Dengue Shock Syndrome

Kumar

Basavaraja

et al. 2017

Arch Clin Infect Dis

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Introduction: Dengue infection has become a serious health problem. It is endemic in most countries of the South-East Asian region. In hyperendemic regions, DHF is more common in children less than 15 years of age. There have been increasing reports of DF and DHF with atypical manifestations (Expanded dengue syndrome). The spectrum of cardiac involvement varies from conduction rhythm disturbances to myocarditis causing hypotension. Case Presentation: Arrhythmias are the first and early indicator of myocarditis. We report an 11-year-old girl who developed Junctional rhythm associated with dengue shock syndrome (DSS) from Mysore, India. Timely ECG will help the clinician detect cardiac involvement. Conclusions: Even though cardiac involvement is rare in dengue fever, arrhythmias do occur. They are essential to diagnose, as they are the first signs of acute myocarditis. Arrhythmias with dengue shock may pose difficulties in the fluid management and use of inotropes. Simple ECG will help the clinician diagnose and monitor arrhythmias.

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Section: Th -8th Daymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Junctional Rhythm in a Child with Dengue Shock Syndrome

Kumar

Basavaraja

et al. 2017

Arch Clin Infect Dis

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“…1,4 Insidens infeksi virus dengue dilaporkan se makin me ningkat, laporan mengenai terjadinya manifes tasi klinis yang atipikal, termasuk keterlibatan/ gang guan jantung juga meningkat. Insidens keterlibatan jantung pada pasien infeksi virus dengue belum diketahui secara pasti.…”

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“…[5][6][7][8] Gangguan jantung terjadi akibat hipoperfusi, invasi langsung otot jantung, atau akibat respon imunologis. 4,7,9 Gejala klinis keterlibatan jantung pada pasien infeksi virus dengue bervariasi luas, mulai dari tidak bergejala/silent disease hingga miokarditis berat yang menyebabkan kematian. 4,10 Sebelumnya, telah dilakukan berbagai penelitian menggunakan biomarker jantung untuk mengetahui keterlibatan jantung pada infeksi virus dengue.…”

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Perbedaan Kadar Troponin T dan Troponin I Serum pada Berbagai Derajat Infeksi Virus Dengue Anak

Sudjadi¹,

Dlh²,

Kuswiyanto³

2018

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Latar belakang. Perbedaan kadar troponin T diketahui berhubungan dengan derajat infeksi virus dengue, tetapi belum diketahui pada troponin I. Tujuan. Mengetahui perbedaan kadar troponin T dan I pada berbagai derajat infeksi virus dengue anak. Metode. Penelitian observasional analitik, rancangan potong lintang pada anak kelompok demam dengue (DD), demam berdarah dengue tanpa syok (DBD), dan sindrom syok dengue (SSD) di RSUP Dr.Hasan Sadikin, RSUD: Majalaya, Cibabat, dan Kota Bandung. Troponin T dan I diperiksa saat awal perawatan dan fase pemulihan. Analisis: uji Kruskal Wallis +analisis post hoc, dan uji Wilcoxon. Hasil. Didapat 49 anak infeksi virus dengue. Hasil pemeriksaan kelompok DD, DBD, dan SSD (berturut-turut) adalah troponin T awal: 3,32, 3,0, 9,01 pg/mL, pemulihan (kurang jelas, lebih baik disebutkan rerata hari ke berapa sakit): 3,0, 3,0, 6,21 pg/mL, Troponin I awal: 2,10, 2,25, 14,20 ng/L, pemulihan: 2,10, 1,50, 14,35 ng/L. Perbedaan kadar troponin T awal: p=0,015, pemulihan: p=0,009, troponin I awal: p=0,032, pemulihan: p=0,062. Perbedaan pemeriksaan awal dan fase pemulihan kelompok DD, DBD, dan SSD (berturut-turut): Troponin T: p=0, 420, 0,055, 0,248, Troponin I: p=0,202, 0,077, 0,285. Kesimpulan. Terdapat perbedaan kadar troponin T dan I pada berbagai derajat infeksi virus dengue anak, kecuali kadar troponin I fase pemulihan. Tidak terdapat perbedaan kadar troponin T dan I antara awal perawatan dan fase pemulihan.

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Myo‐inositol oxygenase (MIOX) accelerated inflammation in the model of infection‐induced cardiac dysfunction by NLRP3 inflammasome

Zhou

Long

2023

Immunity Inflam & Disease

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Background Cardiac dysfunction is an important component of multiple organ failure caused by sepsis, and an important cause of high mortality in patients with sepsis. Herein, we attempted to determine whether myo‐inositol oxygenase (MIOX) has proinflammation enzyme in infection‐induced cardiac dysfunction (IICD) and its underlying mechanism. Methods Patients with IICD were collected by our hospital. A mouse model of IICD was induced into male db/db mice by cecal ligation and puncture (CLP). All mice were injected with 20 μL of LV‐MIOX or LV‐control short hairpin RNA using a 0.5‐mL insulin syringe. On the second day, all mice were induced by CLP. H9C2 cell was also induced with lipopolysaccharide and adenosine triphosphate. Quantitative analysis of messenger RNAs (mRNAs) and gene microarray hybridization was used to analyze the mRNA expression levels. Enzyme‐linked immunosorbent assay, immunofluorescence, and Western blot analysis were used to analyze the protein expression levels. Results The serum expressions of MIOX mRNA level in patients with IICD were upregulated compared to normal healthy volunteers. MIOX promoted inflammation levels in the in vitro model of IICD. Si‐MIOX inhibited inflammation levels in the in vitro model of IICD. MIOX accelerated inflammation and cardiac dysfunction in infection‐induced mice. MIOX interacted with NLR family pyrin domain containing 3 (NLRP3) protein to reduce the degradation of NLRP3. The inhibition of MIOX reversed the effects of NLRP3 in the in vitro model of cardiac dysfunction. Conclusions Taken together, these findings demonstrate that MIOX accelerates inflammation in the model of IICD, which may be, at least in part, attributable to NLRP3 activity by the suppression of NLRP3 degradation in IICD.

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Cardiac involvement in dengue infection

Cited by 40 publications

References 43 publications

Junctional Rhythm in a Child with Dengue Shock Syndrome

Junctional Rhythm in a Child with Dengue Shock Syndrome

Perbedaan Kadar Troponin T dan Troponin I Serum pada Berbagai Derajat Infeksi Virus Dengue Anak

Myo‐inositol oxygenase (MIOX) accelerated inflammation in the model of infection‐induced cardiac dysfunction by NLRP3 inflammasome

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