Cardiac involvement in Churg-Strauss syndrome: a follow-up of three cases

Renaldini, E; Spandrio, Sara; Cerudelli, B.; Affatato, A; Balestrieri, Gian Paolo

doi:10.1093/eurheartj/14.12.1712

Cited by 20 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In some patients with EGPA, mononeuritis multiplex, heart failure, or antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis do not respond to the combination therapy of corticosteroids (CS) and cyclophosphamide (CYC) 3,4 . We reported 5 that intravenous immunoglobulin (IVIG) therapy improved severe mononeuritis multiplex or heart failure in patients with EGPA who did not respond to the combination therapy.…”

mentioning

confidence: 99%

High-dose Intravenous Immunoglobulin Treatment Increases Regulatory T Cells in Patients with Eosinophilic Granulomatosis with Polyangiitis

Tsurikisawa¹,

Saitô²,

Oshikata³

et al. 2012

J Rheumatol

View full text Add to dashboard Cite

Objective.We studied the effects of intravenous immunoglobulin (IVIG) treatment on clinical symptoms and regulatory T (Treg) cell frequency in patients with eosinophilic granulomatosis with polyangiitis (EGPA).Methods.Twenty-two EGPA patients with severe mononeuritis multiplex or cardiac dysfunction received IVIG therapy combined with conventional therapy (corticosteroid, immunosuppressants, or both). As a control, 24 EGPA patients without severe vasculitic symptoms were treated with conventional therapy. Before, during, and after treatment, we determined percentages of Treg cells and other relevant cells in patients’ peripheral blood.Results.The frequency of CD25+ among CD4+ T cells was lower at onset in the study group than in controls but increased significantly after IVIG treatment, relative to controls. The frequency of CD25+ among CD4+ T cells correlated with the frequency of FOXP3+ among CD4+ T cells and interleukin 10 produced by CD25+CD4+ T cells.Conclusion.The increase in Treg cells seen with the combination of IVIG and conventional therapy may promote remission in EGPA.

show abstract

mentioning

confidence: 99%

High-dose Intravenous Immunoglobulin Treatment Increases Regulatory T Cells in Patients with Eosinophilic Granulomatosis with Polyangiitis

Tsurikisawa¹,

Saitô²,

Oshikata³

et al. 2012

J Rheumatol

View full text Add to dashboard Cite

show abstract

“…Corticosteroids and immunosuppressants, especially CYC, have improved considerably most symptoms of vasculitis, particularly those involving the gastrointestinal system, skin, and lungs, as well as constitutional symptoms. However mononeuritis multiplex and heart failure in patients with CSS or ANCA-associated systemic vasculitis do not respond to combination therapy with CS and CYC (Abril et al, 2003;Hattori et al, 1999;Renaldini et al, 1993;Sehgal et al, 1995). IVIG therapy has been used to treat various diseases, including MPA, WG, and ANCA-associated systemic vasculitis (Jayne et al, 1991;Lockwood, 1996;Richter et al, 1995).…”

Section: Treatmentmentioning

confidence: 99%

The Etiology, Mechanisms, and Treatment of Churg-Strauss Syndrome

Tsurikisawa¹,

Saitô²,

Oshikata³

et al. 2011

Advances in the Etiology, Pathogenesis and Pathology of Vasculitis

View full text Add to dashboard Cite

“…Five of the 13 patients initially reported by Churg & Strauss (1) had heart failure. The myocardial dysfunction may be improved by a therapy combining steroids (73) and cyclophosphamide (74). Heart, or heart and lung transplantation has been proposed (72, 75), but the lack of control of the systemic vasculitis may lead to the recurrence of the disease in the transplanted heart (76).…”

Section: Clinical Featuresmentioning

confidence: 99%